Decreased serum total T3 level in hepatitis B and C related cirrhosis by severity of liver damage

Mansour-Ghanaei, Fariborz; Mehrdad, Mojtaba; Khatibani, Seyyedeh Sahereh Mortazavi; Joukar, Farahnaz; Khak, Mohammad; Atrkarroushan, Zahra

doi:10.1016/s1665-2681(19)31440-1

Cited by 44 publications

(51 citation statements)

References 19 publications

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“…Bano et al revealed that higher TSH levels were associated with increased fibrosis risk in patients with non‐alcoholic fatty liver disease. Decreased levels of TT3 and TT4 have been observed in cirrhotic patients, with a negative correlation with cirrhosis severity . The FT3 level was also found to be lower in cirrhotic patients than in controls .…”

Section: Discussionmentioning

confidence: 88%

“…The findings from previous studies suggest that alterations in thyroid hormones are associated with an increased risk of liver cirrhosis of various etiologies, [17][18][19] but the reported patterns of thyroid hormone abnormality have varied markedly. In the present crosssectional study, we first investigated alterations in thyroid hormone levels with fibrosis progression.…”

Section: Introductionmentioning

confidence: 99%

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Development and validation of a novel score for fibrosis staging in patients with chronic hepatitis B

Rao

Chen

et al. 2018

Liver International

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Development and validation of a novel score for fibrosis staging in patients with chronic hepatitis B

Rao

Chen

et al. 2018

Liver International

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“…Moreover, THs and TRs appear to have preventive activities against chronic liver cirrhosis. A previous study revealed that the serum levels of THs are decreased in HBV- and HCV-infected patients [17]. HCC is accompanied by a significant increase in serum rT 3 (inactive form of T 3 ) levels in patients with low-grade HCV-related liver cirrhosis [115].…”

Section: Roles Of Thyroid Hormones and Thyroid Receptors In Liver mentioning

confidence: 99%

“…Earlier studies reported that treatment with T 3 analogs prevents hepatic steatosis and hepatitis [11–16]. Additionally, THs have potential therapeutic applications in hepatitis B and C [17, 18]. Interestingly, T 3 and TRs also play important roles in the pathogenesis of hepatocellular carcinoma (HCC).…”

Section: Introductionmentioning

confidence: 99%

Molecular Functions of Thyroid Hormones and Their Clinical Significance in Liver-Related Diseases

Cheng

Chen

Tsai

et al. 2013

BioMed Research International

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Thyroid hormones (THs) are potent mediators of several physiological processes, including embryonic development, cellular differentiation, metabolism, and cell growth. Triiodothyronine (T3) is the most biologically active TH form. Thyroid hormone receptors (TRs) belong to the nuclear receptor superfamily and mediate the biological functions of T3 via transcriptional regulation. TRs generally form heterodimers with the retinoid X receptor (RXR) and regulate target genes upon T3 stimulation. Research over the past few decades has revealed that disruption of cellular TH signaling triggers chronic liver diseases, including alcoholic or nonalcoholic fatty liver disease and hepatocellular carcinoma (HCC). Animal model experiments and epidemiologic studies to date imply close associations between high TH levels and prevention of liver disease. Moreover, several investigations spanning four decades have reported the therapeutic potential of T3 analogs in lowering lipids, preventing chronic liver disease, and as anticancer agents. Thus, elucidating downstream genes/signaling pathways and molecular mechanisms of TH actions is critical for the treatment of significant public health issues. Here, we have reviewed recent studies focusing on the roles of THs and TRs in several disorders, in particular, liver diseases. We also discuss the potential therapeutic applications of THs and underlying molecular mechanisms.

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“…Gastrointestinal and liver diseases are among the most common causes of morbidity in Iran and constitute a substantial proportion of mortality, which imposes enormous economic consequences (1, 2). Prognosis is an important part of the baseline assessment of any disease.…”

Section: Introductionmentioning

confidence: 99%

Introducing an Optimal Liver Allocation System for Liver Cirrhosis Patients

et al. 2013

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BackgroundLiver transplantation (LT) is the only treatment option for patients with advanced liver disease. Currently, liver donation to these patients, considering priorities, is based on the Model for End-Stage Liver Disease (MELD). MELD score is a tool for predicting the risk of mortality in patients with advanced liver disease. However, few studies have so far been conducted in Iran on the efficacy of MELD score of these patients.ObjectivesThis study reviews the present status of the MELD score and introduces a new model for optimal prediction of the risk of mortality in Iranian patients with advanced liver disease.Patients and MethodsData required were collected from 305 patients with advanced liver disease who enrolled in a waiting list (WL) in Imam Khomeini Hospital from May 2008 to May 2009. All of the patients were followed up for at least 3 years until they died or underwent LT. Cox regression analysis was applied to select the factors affecting their mortality. Survival curves were plotted. Wilcoxson test and receiver operating characteristics curves for survival predictive model were used to compare the scores. All calculations were performed with the SPSS (version 13.0) and R softwares.ResultsDuring the study, 71 (23.3%) patients died due to liver cirrhosis and 43 (14.1%) underwent LT. Viral Hepatitis (43.7%) is the most common cause of end-stage liver disease among Iranian patients. A new model (NMELD) was proposed with the use of the natural logarithms of two blood serum variables (total bilirubin and albumin) and the patients' age (year) by applying the Cox model:NMELD = 10 × (0.736 × ln (bilirubin) – 1.312 × ln (albumin) + 0.025 × age + 1.776)ConclusionsThe results of the Wilcoxon test showed that there is a significant difference between the usual MELD and our proposed NMELD scores (P < 0.001). Receiver operating characteristics curve for survival predictive model indicated that the NMELD score is more efficient compared with the MELD score in predicting the risk of mortality. Since serum creatinine was not significant in NMELD score, further studies to clarify this issue are suggested.

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Decreased serum total T3 level in hepatitis B and C related cirrhosis by severity of liver damage

Cited by 44 publications

References 19 publications

Development and validation of a novel score for fibrosis staging in patients with chronic hepatitis B

Development and validation of a novel score for fibrosis staging in patients with chronic hepatitis B

Molecular Functions of Thyroid Hormones and Their Clinical Significance in Liver-Related Diseases

Introducing an Optimal Liver Allocation System for Liver Cirrhosis Patients

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