Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Depression Correlates with Severity of Disease

Russo, Anthony J.

doi:10.4137/bmi.s5183

Cited by 12 publications

(11 citation statements)

References 33 publications

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“… 41 HGF enhances long-term potentiation, 42 improves or attenuates ischemia-related memory deficits 43 and Aβ-induced behavioral impairment, 44 and has anxiolytic properties, 45 whereas its suppression increases anxiety and depressive behaviors in rodents. 46 To our knowledge, only two studies have investigated HGF in relation to depression in humans, one of which found significantly lower serum HGF levels among 26 people with major depression compared with 19 controls, 47 whereas the other study found no difference in HGF levels in 12 women with major depression and borderline personality disorder. 48 Higher serum levels of HGF have also been found in those patients with panic disorder who best responded to antidepressant medication.…”

Section: Discussionmentioning

confidence: 97%

Plasma biomarkers of depressive symptoms in older adults

et al. 2012

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The pathophysiology of negative affect states in older adults is complex, and a host of central nervous system and peripheral systemic mechanisms may play primary or contributing roles. We conducted an unbiased analysis of 146 plasma analytes in a multiplex biochemical biomarker study in relation to number of depressive symptoms endorsed by 566 participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) at their baseline and 1-year assessments. Analytes that were most highly associated with depressive symptoms included hepatocyte growth factor, insulin polypeptides, pregnancy-associated plasma protein-A and vascular endothelial growth factor. Separate regression models assessed contributions of past history of psychiatric illness, antidepressant or other psychotropic medicine, apolipoprotein E genotype, body mass index, serum glucose and cerebrospinal fluid (CSF) τ and amyloid levels, and none of these values significantly attenuated the main effects of the candidate analyte levels for depressive symptoms score. Ensemble machine learning with Random Forests found good accuracy (∼80%) in classifying groups with and without depressive symptoms. These data begin to identify biochemical biomarkers of depressive symptoms in older adults that may be useful in investigations of pathophysiological mechanisms of depression in aging and neurodegenerative dementias and as targets of novel treatment approaches.

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Section: Discussionmentioning

confidence: 97%

Plasma biomarkers of depressive symptoms in older adults

et al. 2012

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“…Further, there are indications in the literature that HGF has neuroprotective functions (Jamali-raoufi, Haghani, Roghani, Fahanik-Babaei, & Baluchnejadmojarad, 2017;Wright & Harding, 2015). Lower HGF levels have been described in individuals with more severe clinically diagnosed depression (Russo, 2010), and an experimental study in rats suggests that inhibition of HGF might trigger depressive-like behavior (Wakatsuki et al, 2007). However, HGF have been reported elevated in older adults with subclinical symptoms of depression (Arnold et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Inflammatory markers in women with postpartum depressive symptoms

Bränn

Fransson

White

et al. 2018

J of Neuroscience Research

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Postpartum depression (PPD) is a devastating disorder affecting not only more than 10% of all women giving birth, but also the baby, the family, and the society. Compiling evidence suggests the involvement of the immune system in the pathophysiology of major depression; yet, the immune response in perinatal depression is not as well studied. The aim of this study was to investigate the alterations in peripheral levels of inflammatory biomarkers in 169 Swedish women with and without depressive symptoms according to the Edinburgh postnatal depression scale or the M.I.N.I neuropsychiatric interview at eight weeks postpartum. Among the 70 markers analyzed with multiplex proximity extension assay, five were significantly elevated in women with postpartum depressive symptoms in the adjusted LASSO logistic regression analysis: Tumor necrosis factor ligand superfamily member (TRANCE) (OR-per 1 SD increase = 1.20), Hepatocyte growth factor (HGF) (OR = 1.17) Interleukin (IL)-18 (OR = 1.06), Fibroblast growth factor 23 (FGF-23) (OR = 1.25), and C-X-C motif chemokine 1 (CXCL1) (OR 1.11). These results indicate that women with PPD have elevated levels of some inflammatory biomarkers. It is, therefore, plausible that PPD is associated with a compromised adaptability of the immune system.

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“…The results reported here support previous findings of our lab and others who have found zinc deficiency in patients with depression, 33–35 and anxiety, 36 and have suggested zinc homeostasis for possible therapy. 37–39…”

Section: Discussionmentioning

confidence: 99%

“…The results reported here support previous findings of our lab and others who have found zinc deficiency in patients with depression, [33][34][35] and anxiety, 36 and have suggested zinc homeostasis for possible therapy. [37][38][39] In addition, elevated copper has been associated with women having a history of post-partum depression 40 and clinical depression has been associated with high copper in patients with Wilson's disease. 41 There is much support for the role of GABA and glutamate in mood disorders, particularly anxiety and depression.…”

Section: Discussionmentioning

confidence: 99%

Decreased Zinc and Increased Copper in Individuals with Anxiety

Russo

2011

Nutr Metab Insights

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Aim:To assess plasma zinc and copper levels in individuals with anxiety and to test the hypothesis that there is a relationship between copper and zinc concentration and improved symptoms.Subjects and methods:Serum from 38 individuals with anxiety and 16 neurotypical age, gender and size similar controls were tested for plasma zinc and copper concentration using inductively-coupled plasma-mass spectrometry. Zinc and copper levels, pre and post therapy, were compared and assessed for perceived anxiety symptoms.Results:In this preliminary study, individuals with anxiety had significantly higher plasma levels of Cu (P = 0.0348), Cu/Zn (P = 0.0493) and lower Zn (P = 0.0294) compared to controls. Zn levels normalized (increased to the normal range) and Cu/Zn significantly decreased after zinc therapy (P = 0.0004, P = 0.0033, respectively), but Cu did not significantly decrease (0.3577). These same patients improved significantly with respect to perceived overall symptoms after zinc and anti-oxidant therapy (P = 0.013).Discussion:These results suggest an association between Zn plasma levels and individuals with anxiety, demonstrate that zinc therapy is effective in increasing zinc plasma levels, and show that zinc supplementation may play a role in improved symptoms.

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Decreased Serum Hepatocyte Growth Factor (HGF) in Individuals with Depression Correlates with Severity of Disease

Cited by 12 publications

References 33 publications

Plasma biomarkers of depressive symptoms in older adults

Plasma biomarkers of depressive symptoms in older adults

Inflammatory markers in women with postpartum depressive symptoms

Decreased Zinc and Increased Copper in Individuals with Anxiety

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