Inflammatory markers in women with postpartum depressive symptoms

Bränn, Emma; Fransson, Emma; White, Richard A.; Papadopoulos, Fotios C.; Edvinsson, Åsa; Kamali‐Moghaddam, Masood; Cunningham, Janet L.; Sundström‐Poromaa, Inger; Skalkidou, Alkistis

doi:10.1002/jnr.24312

Cited by 50 publications

(44 citation statements)

References 97 publications

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“…However, MIP-1α (i.e., CCL3), CCL4, and CCL20, the macrophage-released pro-inflammatory molecules, were significantly elevated in the patients, consistent with previous MDD reports [51,52]. IL-18 was the only inflammatory marker that correlated with the MADRS-S score and is consistent with other studies of inflammatory markers and depression [53][54][55][56]. Many inflammatory markers correlated with age in both CBD and the patients in concordance with previous studies [57][58][59][60].…”

Section: Inflammatory Markers In Psychiatric Disorderssupporting

confidence: 90%

Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers

Bhandage

Cunningham

Jin

et al. 2019

IJMS

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Immunomodulation is increasingly being recognised as a part of mental diseases. Here, we examined whether levels of immunological protein markers changed with depression, age, or the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). An analysis of plasma samples from patients with a major depressive episode and control blood donors (CBD) revealed the expression of 67 inflammatory markers. Thirteen of these markers displayed augmented levels in patients compared to CBD. Twenty-one markers correlated with the age of the patients, whereas 10 markers correlated with the age of CBD. Interestingly, CST5 and CDCP1 showed the strongest correlation with age in the patients and CBD, respectively. IL-18 was the only marker that correlated with the MADRS-S scores of the patients. Neuronal growth factors (NGFs) were significantly enhanced in plasma from the patients, as was the average plasma GABA concentration. GABA modulated the release of seven cytokines in anti-CD3-stimulated peripheral blood mononuclear cells (PBMCs) from the patients. The study reveals significant changes in the plasma composition of small molecules during depression and identifies potential peripheral biomarkers of the disease.

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Section: Inflammatory Markers In Psychiatric Disorderssupporting

confidence: 90%

Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers

Bhandage

Cunningham

Jin

et al. 2019

IJMS

Self Cite

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“…Such a solution may provide an effective resource to discover disease pathways and identify novel therapeutic targets for individualised treatment based on biomarker profiling [8]. The proximity extension assay has been shown to be useful for biomarker discovery in cardiometabolic disease [9], immunology [10], cardio-oncology [11] and neuroscience research [12]. Moreover, multiprotein assays have been used to discover key mechanisms by which CV autonomic dysfunction is associated with increased CV morbidity and mortality [13,14].…”

Section: Introductionmentioning

confidence: 99%

Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome

Spahic

Ricci

Aung

et al. 2020

BMC Cardiovasc Disord

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Background: Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular (CV) autonomic disorder of unknown etiology characterized by an excessive heart rate increase on standing and orthostatic intolerance. In this study we sought to identify novel CV biomarkers potentially implicated in POTS pathophysiology. Methods: We conducted a nested case-control study within the Syncope Study of Unselected Population in Malmö (SYSTEMA) cohort including 396 patients (age range, 15-50 years) with either POTS (n = 113) or normal hemodynamic response during passive head-up-tilt test (n = 283). We used a targeted approach to explore changes in cardiovascular proteomics associated with POTS through a sequential two-stage process including supervised principal component analysis and univariate ANOVA with Bonferroni correction. Results: POTS patients were younger (26 vs. 31 years; p < 0.001) and had lower BMI than controls. The discovery algorithm identified growth hormone (GH) and myoglobin (MB) as the most specific biomarker fingerprint for POTS. Plasma level of GH was higher (9.37 vs 8.37 of normalised protein expression units (NPX); p = 0.002), whereas MB was lower (4.86 vs 5.14 NPX; p = 0.002) in POTS compared with controls. In multivariate regression analysis, adjusted for age and BMI, and stratified by sex, lower MB level in men and higher GH level in women remained independently associated with POTS. Conclusions: Cardiovascular proteomics analysis revealed sex-specific biomarker signature in POTS featured by higher plasma level of GH in women and lower plasma level of MB in men. These findings point to sex-specific immune-neuroendocrine dysregulation and deconditioning as potentially key pathophysiological traits underlying POTS.

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“…release of pro-in ammatory cytokines) towards later pregnancy and into the postpartum period (48). Depressive disorders are increasingly associated with in ammation (24,25), providing a putative link between unusually prolonged or excessive immune activation during pregnancy and perinatal depression (15). Recent research suggests that maternal immune pro les may vary by fetal sex, with women carrying a male having increased levels of pro-in ammatory markers (19,49).…”

Section: Discussionmentioning

confidence: 99%

Fetal sex and maternal postpartum depressive symptoms: findings from two prospective pregnancy cohorts

Cowell

Colicino

Askowitz

et al. 2020

Preprint

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Background: Fetal sex is known to modify the course and complications of pregnancy, with recent evidence of sex-differential fetal influences on the maternal immune and endocrine systems. In turn, heightened inflammation and surges in reproductive hormone levels associated with pregnancy and parturition have been linked with the development of perinatal depression. Here, we examined whether there is an association between fetal sex and maternal depression assessed during the prenatal and postnatal periods.Methods: The study included two multi-ethnic, prospective pregnancy cohorts that enrolled women from prenatal clinics in the Northeastern United States between 2001 and 2018. Maternal depressive symptoms were measured during the prenatal and postnatal periods using the Edinburgh Postpartum Depression Scale (EPDS) and newborn sex was reported by the mother following delivery. We used logistic regression to examine associations between fetal sex and maternal depressive symptoms (EPDS>10) during the prenatal period only, postnatal period only, or both periods versus no depressive symptoms during either period. We considered both unadjusted models and models adjusted for a core set of sociodemographic and lifestyle variables. Results: In adjusted models conducted using PRISM data (N=528), women pregnant with a male versus female fetus had significantly greater odds of depressive symptoms during the postnatal period compared to women without depressive symptoms during either period (odds ratio [OR] = 5.24, 95% confidence interval [CI] = 1.93, 14.21). The direction of results was consistent in the ACCESS cohort, although the findings did not reach statistical significance (OR = 2.05, 95% CI = 0.86, 4.93). Significant associations were not observed in either cohort among women with prenatal symptoms only or women with prenatal and postnatal symptoms. Conclusions: Male fetal sex was associated with the onset of depressive symptoms during the postnatal period.

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Inflammatory markers in women with postpartum depressive symptoms

Cited by 50 publications

References 97 publications

Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers

Depression, GABA, and Age Correlate with Plasma Levels of Inflammatory Markers

Proteomic analysis reveals sex-specific biomarker signature in postural orthostatic tachycardia syndrome

Fetal sex and maternal postpartum depressive symptoms: findings from two prospective pregnancy cohorts

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