Decreased Serum Fetuin-A Levels are Associated with Coronary Artery Diseases

Bilgir, Oktay; Kebapçılar, Levent; Bilgir, Ferda; Bozkaya, Giray; Yıldız, Yaşar; Pınar, Pelin; Taştan, Ahmet

doi:10.2169/internalmedicine.49.3223

Cited by 47 publications

(43 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, some clinical studies have indicated the opposite trends-a decrease in fetuin-A levels have been associated with the presence of PAD in diabetics, an increased arterial stiffness, atherosclerotic plaque calcification and progression of cardiovascular disease 14,48 . Contrary to some reports, many previous studies indicate that fetuin-A concentrations are decreased in patients with stable angina and acute myocardial infarction, this glycoprotein may be independent predictor of death after ST-elevation myocardial infarction and low levels of fetuin-A are correlated to the severity of coronary arterial calcification 49,50,51 . It should be mentioned that the renal function has influence on cardiovascular risk due to accelerated vascular calcifications aggravated by hyperphosphataemia and hypercalcaemia.…”

Section: Fetuin-a As a Marker Of Cardiovascular Diseasecontrasting

confidence: 79%

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

et al. 2015

View full text Add to dashboard Cite

Section: Fetuin-a As a Marker Of Cardiovascular Diseasecontrasting

confidence: 79%

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

et al. 2015

View full text Add to dashboard Cite

“…5,17,18 In addition, the negative correlation we showed between CRP and fetuin-A, and the negative correlation with ESR and CRP demonstrated in studies involving chronic kidney failure, cardiovascular disease, and rheumatic diseases indicate that fetuin-A may be a negative acute phase reactant. 5,[16][17][18][19] In conclusion, we demonstrated that fetuin-A levels in AS patients were lower than in control subjects. We also showed that fetuin-A is negatively correlated with CRP.…”

Section: Discussionmentioning

confidence: 50%

Serum Fetuin-A Level in Patients With Ankylosing Spondylitis and its Relationship With Clinical Parameters

et al. 2015

View full text Add to dashboard Cite

Objectives:This study aims to investigate the association of serum fetuin-A levels with disease activation and clinical parameters in ankylosing spondylitis (AS) patients. Patients and methods: Forty-seven AS patients (30 males, 17 females; mean age 39.7±11.1 years; range 20 to 69 years) and 30 healthy controls (14 males, 16 females; mean age 42.0±11.5 years; range 19 to 63 years) were included in the study. Erythrocyte sedimentation rate, C-reactive protein, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Radiology Index, and Bath Ankylosing Spondylitis Metrology Index were used in the assessment of AS. Serum fetuin-A levels were measured using ELISA. Results: Mean serum fetuin-A values in AS patients (984±203 ng/mL) were significantly lower compared to controls (1156±218 ng/mL) (p=0.001). While a statistically significant negative correlation was detected in AS patients between fetuin-A values and C-reactive protein (p=0.009, r=-0.377), no significant correlation was detected between erythrocyte sedimentation rate, Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Metrology Index, Bath Ankylosing Spondylitis Functional Index or Bath Ankylosing Spondylitis Radiology Index parameters and fetuin-A. Conclusion: Serum fetuin-A levels in AS patients were lower than the control group. However, further research is required to establish the role of serum fetuin-A levels as a surrogate marker of disease activity.

show abstract

“…It is internalized mainly by the Kupffer cells of the liver and macrophages in the splenic marginal zone, and carries out the calcium clearance (2,3). Various studies have demonstrated an association between reduced plasma fetuin-A levels and increased vascular calcification and cardiovascular mortality in dialysis patients, increased risk of peripheral arterial disease, and coronary artery disease in patients with type 2 diabetes (4,5,6). Studies have therefore defined reduced plasma fetuin-A levels as a new cardiovascular risk factor and demonstrated that severity of atherosclerosis increases with low plasma fetuin-A levels (7,8).…”

Section: Introductionmentioning

confidence: 99%

Plasma fetuin-A levels are reduced in patients with hypothyroidism

Bakıner

Bozkirli

Ertuğrul³

et al. 2014

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: To determine plasma fetuin-A levels in hypothyroid patients before and after treatment with L-thyroxine (T 4 ) and to determine the relation between plasma fetuin-A levels with cardiovascular risk factors. Design: A prospective, controlled, single-blind study. Methods: Forty-four treatment-naive female patients diagnosed with hypothyroidism and 39 age-and sex-matched control subjects were enrolled. Anthropometric measurements, blood pressure, plasma TSH, fetuin-A, free T 4 , LDL-cholesterol, triglyceride, C-reactive protein, fibrinogen levels, and brachial artery flow-mediated dilatation were measured. All measurements were repeated after 3 months in the control group and 3 months after the attainment of euthyroidism with L-T 4 replacement in the hypothyroid group. Baseline data were compared between the two groups. Posttreatment plasma fetuin-A levels of hypothyroid patients were compared with baseline levels of both groups. The relationship between plasma fetuin-A, TSH levels, and other cardiovascular risk factors was evaluated. Results: Plasma fetuin-A levels were w20% lower in hypothyroid female patients compared with the controls (PZ0.0001). Fetuin-A levels increased by w20% in hypothyroid patients after achievement of euthyroidism (PZ0.0001) and were no longer different compared with controls (PZ0.38). There was a negative correlation between plasma TSH and fetuin-A levels (rZK0.79; PZ0.001). There was no significant correlation between plasma fetuin-A levels and cardiovascular risk factors within or between groups. The fetuin-A levels were normalized with thyroid hormone treatment. Conclusion: Plasma fetuin-A levels are reduced in female patients with hypothyroidism, which are restored to normal during restoration of euthyroidism. There was no relation with cardiovascular risk factors.

show abstract

Decreased Serum Fetuin-A Levels are Associated with Coronary Artery Diseases

Cited by 47 publications

References 22 publications

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Serum Fetuin-A Level in Patients With Ankylosing Spondylitis and its Relationship With Clinical Parameters

Plasma fetuin-A levels are reduced in patients with hypothyroidism

Contact Info

Product

Resources

About