Plasma fetuin-A levels are reduced in patients with hypothyroidism

Abstract

Objective: To determine plasma fetuin-A levels in hypothyroid patients before and after treatment with L-thyroxine (T 4 ) and to determine the relation between plasma fetuin-A levels with cardiovascular risk factors. Design: A prospective, controlled, single-blind study. Methods: Forty-four treatment-naive female patients diagnosed with hypothyroidism and 39 age-and sex-matched control subjects were enrolled. Anthropometric measurements, blood pressure, plasma TSH, fetuin-A, free T 4 , LDL-cholesterol, triglyceride, C-reactive protein, fibrinogen levels, and brachial artery flow-mediated dilatation were measured. All measurements were repeated after 3 months in the control group and 3 months after the attainment of euthyroidism with L-T 4 replacement in the hypothyroid group. Baseline data were compared between the two groups. Posttreatment plasma fetuin-A levels of hypothyroid patients were compared with baseline levels of both groups. The relationship between plasma fetuin-A, TSH levels, and other cardiovascular risk factors was evaluated. Results: Plasma fetuin-A levels were w20% lower in hypothyroid female patients compared with the controls (PZ0.0001). Fetuin-A levels increased by w20% in hypothyroid patients after achievement of euthyroidism (PZ0.0001) and were no longer different compared with controls (PZ0.38). There was a negative correlation between plasma TSH and fetuin-A levels (rZK0.79; PZ0.001). There was no significant correlation between plasma fetuin-A levels and cardiovascular risk factors within or between groups. The fetuin-A levels were normalized with thyroid hormone treatment. Conclusion: Plasma fetuin-A levels are reduced in female patients with hypothyroidism, which are restored to normal during restoration of euthyroidism. There was no relation with cardiovascular risk factors.

Relationship of Serum Fetuin A with Metabolic and Clinical Parameters in German Children and Adolescents with Type 1 Diabetes

“…Other authors have found significantly lower plasma fetuin A levels in nondiabetic adult patients with hypothyroidism or Hashimoto thyroiditis [53, 56], but we could not reproduce these findings in our cohort as we did not see a correlation with thyroid-stimulating hormone levels or a clinical diagnosis of thyroiditis. In contrast to some previous reports in non-T1D cohorts, fetuin A levels were not associated with dyslipidemia, any single lipid parameter [8, 9, 14, 55], or microalbuminuria [57].…”

Proteomics in thyroid cytopathology: Relevance of MALDI‐imaging in distinguishing malignant from benign lesions

“…Selenium is also very promoting as a therapeutic treatment: many studies show that, in autoimmune thyroiditis, the administration of selenium can cause a significant drop in the antibody level (anti‐TPO) . Evaluating the levels of protein markers such as Futuin‐A and CXCL10's may have potential relevance given that they are reported to be increased and decreased in patients, respectively , with a possible diagnostic meaning. Finally, it is significant to consider the variation of FcγRIIB (low‐affinity receptor of IgG) expression on B‐lymphocytes, as the aforementioned autoantibodies exploit the Fcγ receptors in affected patients, given that these receptors are less expressed than in healthy subjects .…”

“…Evaluating the levels of protein markers such as Futuin‐A and CXCL10's may have potential relevance given that they are reported to be increased and decreased in patients, respectively , with a possible diagnostic meaning. Finally, it is significant to consider the variation of FcγRIIB (low‐affinity receptor of IgG) expression on B‐lymphocytes, as the aforementioned autoantibodies exploit the Fcγ receptors in affected patients, given that these receptors are less expressed than in healthy subjects . In addition, HT may represent a challenging disease for pathologists to differentiate from cancer, especially in atypical cytological smears .…”

Rapid sandwich ELISA-based in vitro diagnostic procedure for the highly-sensitive detection of human fetuin A

“…HFA is commonly present in the cortical plate of the immature cerebral cortex and the hemopoietic matrix of bone marrow. Low levels of HFA may indicate cardiovascular risks at an early stage (Stefan, 2013) such as in patients on dialysis (Liang et al, 2014), hypothyroidism (Bakiner et al, 2014), and atherosclerosis (Lim et al, 2007). Moreover, increased serum concentrations of HFA may be responsible for cancer cell adhesion and metastasis (Nangami et al, 2013;Sakwe et al, 2010).…”