Decreased serum BDNF levels in major depressive patients

Sözeri-Varma, Gülfizar; Enli, Yaşar; Toker-Uğurlu, Tuğçe; Alacam, Huseyin; Kalkan-Oğuzhanoğlu, Nalan

doi:10.1016/j.npbr.2011.09.001

Cited by 9 publications

(5 citation statements)

References 34 publications

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“…No difference was determined in the BDNF levels of those with single episode and recurrent episode. In another study that we carried out, the serum BDNF levels of depression patients were determined to be lower than those of the healthy control group (33). Similar to our results, there are studies stating that there is no relationship between serum BDNF levels and the severity or the recurrent nature of depression (34,35).…”

Section: Discussionsupporting

confidence: 86%

Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?

Sözeri-Varma¹,

Enli²,

Aydin³

et al. 2012

JMOOD

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Depresif bozuklukta serum BDNF düzeyleri ile bilişsel işlevler ve kortizol düzeyleri arasındaki ilişki Amaç: Bu çalışmada, depresif bozuklukta serum BDNF düzeyleri ile bilişsel işlevler ve kortizol düzeyleri arasındaki ilişkinin araştırılması amaçlandı. Yöntem: Çalışmaya DSM-IV tanı ölçütlerine göre major depresif bozukluk tanısı konulan ve antidepresan ilaç kullanımı olmayan 30 hasta katıldı. Depresyon şiddetinin belirlenmesinde Hamilton Depresyon Değerlendirme Ölçeği (HAM-D17) kullanıldı. Serum BDNF düzeyleri ELİSA yöntemi ile belirlendi. Bilişsel işlevlerin değerlendirilmesinde; Sayı dizileri testi, Stroop testi, Sözel bellek süreçleri testi ve Wechsler-görsel bellek alt testleri uygulandı. Bulgular: Hastaların HAM-D17 puan ortalaması 17.09±4.96 olarak tespit edildi. Serum BDNF düzeyleri ortalama 1453.42±144.51 pg/ml, serum sabah kortizol düzeyleri 11.54±4.57µg/dL olarak belirlendi. HAM-D17 puanları ile BDNF düzeyleri arasında ilişki saptanmadı. Serum BDNF düzeyleri ile kortizol düzeyleri ve nöropsikolojik test puanları arasında ilişki saptanmadı. Serum kortizol düzeyleri ile Stroop testi süre farkı arasında pozitif ilişki tespit edildi (rs=0.396 p=0.017). Serum kortizol düzeyleri ile diğer nöropsikolojik test puanları arasında ilişki saptanmadı. Sonuç: Çalışmamızda depresyonu olan hastalarda BDNF düzeyleri ile dikkat ve bellek performansları arasında ilişki bulunmamıştır. Sabah bazal kortizol düzeylerinin yüksek olması dikkati olumsuz yönde etkilemektedir. Serum BDNF düzeyleri ile sabah ölçülen kortizol düzeyleri arasında ilişki saptanmamıştır.

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Section: Discussionsupporting

confidence: 86%

Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?

Sözeri-Varma¹,

Enli²,

Aydin³

et al. 2012

JMOOD

View full text Add to dashboard Cite

show abstract

“…Sen et al (38) reported no significant correlation between serum levels of BDNF and sex or age in depressed patients. Karege et al (22) and Sözeri et al (55) reported no significant correlation between serum levels of BDNF and sex or number of depressive episode. In the present study, we did not find any significant correlation between the serum BDNF levels and sex, age, age of onset, duration of the disorder or body mass index in the MDD group.…”

Section: Discussionmentioning

confidence: 96%

Can BDNF and IL-2 be indicators for the diagnosis in schizophrenic patients with depressive symptoms?

Eker

Yavaşcı

Cangür

et al. 2014

Acta Neuropsychiatr.

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“…BDNF is expressed extensively in the cerebral cortex and hippocampus and is important for neuronal proliferation, differentiation, nutrition, and maturity. Serum BDNF levels decreased in patients with major depression and increased after symptoms were relieved due to treatment with antidepressants [ 14 – 16 ]. This research demonstrated that plasma BDNF decreased in rats subjected to 15 min forced swimming stress and increased after being treated with paeoniflorin and fluoxetine, as well as relieving depression-like behavior in rats.…”

Section: Discussionmentioning

confidence: 99%

Antidepression and Prokinetic Effects of Paeoniflorin on Rats in the Forced Swimming Test via Polypharmacology

Xue

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Paeoniflorin, an organic compound extracted from the roots of the white peony (Paeonia lactiflora) plant, has previously been shown to exert antidepression and prokinetic effects. The traditional Chinese prescription Si-Ni-San, of which paeoniflorin is a constituent, is often used in treating depression and functional gastrointestinal disorders. The effectiveness of Si-Ni-San has been shown to be less effective in a paeoniflorin-deleted form. The present study further investigates whether paeoniflorin alone is as effective as herbal prescriptions in which the compound is a constituent, specifically any antidepressive and prokinetic effect on rats subjected to a forced swimming test (FST). The FST was used to establish the depression model. Sprague-Dawley rats were administrated with 10 mg/kg paeoniflorin by gastrogavage three times before the behavioral test and gastrointestinal motility tests, respectively. In antidepression studies, fluoxetine was used as the positive control. In order to determine the effect of paeoniflorin on the gastrointestinal movement, mosapride was used as the positive control. Plasma and hippocampus monoamine, hypothalamic-pituitary-adrenal axis, plasma brain-derived neurotrophic factor (BDNF), superoxide dismutase (SOD), methane dicarboxylic aldehyde (MDA), ghrelin, motilin, and hippocampus nitric oxide (NO) were assessed using an enzyme-linked immunosorbent assay (ELISA). Gastrointestinal (GI) motility was measured in vivo and in vitro. Rats subjected to FST showed decreased gastric emptying and intestinal transit in vivo, decreased plasma and hippocampus 5-hydroxytryptamine, norepinephrine, dopamine, ghrelin, motilin, and reduced plasma BDNF and SOD as well as increased plasma and hippocampus corticotropin-releasing hormone, adrenocorticotropic hormone, corticosterone, plasma MDA, and hippocampus NO. Paeoniflorin reversed these symptoms in a similar manner to fluoxetine and mosapride, respectively. In vitro, paeoniflorin can stimulate the jejunal contract of healthy rats dose-dependently. The results suggest that paeoniflorin can simultaneously exert antidepression and prokinetic effects via polypharmacology.

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Decreased serum BDNF levels in major depressive patients

Cited by 9 publications

References 34 publications

Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?

Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?

Can BDNF and IL-2 be indicators for the diagnosis in schizophrenic patients with depressive symptoms?

Antidepression and Prokinetic Effects of Paeoniflorin on Rats in the Forced Swimming Test via Polypharmacology

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