Relationship between serum BDNF levels and cognitive functions, cortisol levels in depressive disorder?

Sözeri-Varma, Gülfizar; Enli, Yaşar; Aydin, Emel; Toker-Uğurlu, Tuğçe; Alacam, Huseyin; Kalkan-Oğuzhanoğlu, Nalan

doi:10.5455/jmood.20120619051904

Cited by 1 publication

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References 44 publications

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“…BDNF enhances the development of noradrenergic and serotonergic neurons, increasing their life span by preventing them from toxic damage 12). Furthermore, it is effective in neuro-genesis and synaptic plasticity 13). Administration of exogenous BDNF was found to increase complexity and dendrite length of pyramidal neurons in visual cortex development 14).…”

Section: Introductionmentioning

confidence: 99%

Effect of Maternal Depression on Brain-derived Neurotrophic Factor Levels in Fetal Cord Blood

Sönmez¹,

Uğuz²,

Sahingoz³

et al. 2019

Clin Psychopharmacol Neurosci

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Objective We aimed to assess the association between cord blood brain-derived neurotrophic factor (BDNF) concentration and maternal depression during pregnancy. Methods A total of 48 pregnant women, admitted for elective caesarean section to Department of Obstetrics and Gynecology, The Konya Research and Training Hospital and Konya Necmettin Erbakan University Meram Medical Faculty, were included in this study. The study group included 23 women diagnosed as having depression during pregnancy and the control group included 25 pregnant women who did not experience depression during pregnancy. Results The groups had similar sociodemographic characteristics. Cord blood BDNF concentration was significantly lower in babies born to mothers with major depression as compared with those in the control group. We didn’t find any correlation between the umbilical cord blood BDNF levels and BDI scores. Conclusion The results suggest that the existence of major depression in pregnant women may negatively affect fetal circulating BDNF levels.

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Section: Introductionmentioning

confidence: 99%