Decreased sensitivity of the ultrarapid urease test for diagnosing Helicobacter pylori in patients with chronic renal failure

Misra, Vatsala; Misra, Sri Prakash; Dwivedi, Manisha; Shukla, Shubhangi; Agarwal, Reena; Jaiswal, Praveen Kumar; Gupta, S. C.

doi:10.1080/003130299105520

Cited by 6 publications

(8 citation statements)

References 25 publications

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“…9–13,21–59 Patients receiving dialysis had significantly lower prevalence of H. pylori infection in five studies, 22,27,28,40,49 whereas only one study reported that dialysis patients had significantly higher infection rates. 14 In the present study, we investigated the largest number of dialysis patients with a variety of treatment periods, and found that the prevalence of H. pylori infection in dialysis patients with CRF was significantly lower than in patients with normal renal function.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori infection in long-term hemodialysis patients

Sugimoto

Sakai

Kita

et al. 2009

Kidney International

110

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Patients on hemodialysis often have gastrointestinal complications; however, it is unclear if Helicobacter pylori infection is present in these patients. Here we determined the prevalence of H. pylori infection in 539 Japanese hemodialysis patients by measuring serum anti-H. pylori IgG antibodies. Endoscopy was performed on 299 of these patients and the results were compared to 400 patients with normal renal function who had also undergone endoscopy and sero-testing. A second cohort of 478 dialysis patients, within the original group, was checked serologically for H. pylori infection three times over a four-year observation period. The prevalence of infection in these patients was significantly lower than in those patients with normal renal function, irrespective of the clinical outcomes. The prevalence of H. pylori infection significantly decreased as the duration of dialysis increased, particularly within the first four years following initiation of dialysis. About one-third of patients on dialysis for less than four years became serologically negative for H. pylori infection within this observation period. Our study suggests that although long-term dialysis patients have low prevalence of H. pylori, they still have significant gastroduodenal diseases, such as peptic ulcers, that require endoscopic follow-up.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Helicobacter pylori infection in long-term hemodialysis patients

Sugimoto

Sakai

Kita

et al. 2009

Kidney International

110

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“…Previously, eight studies showed significantly lower prevalence of H. pylori infection in patients receiving hemodialysis (8/36 studies, 22.2%) (20,21,25,36,38,48,53,57) compared with controls and one study has found a significantly lower prevalence of H. pylori infection in patients receiving CAPD (1/5 studies, 20.0%) (21); whereas only one study reported that Iranian hemodialysis patients (63.0%) and chronic renal failure patients (66.2%) had significantly higher prevalence of H. pylori infection compared with normal individuals (27.5%) (Table 1) (9). However, since the prevalence of H. pylori infection in the Iranian population is reported to be more than 60% in other reports (63,64), further studies are required to clarify this discrepancy in the Iranian population.…”

Section: Sugimoto and Y Yamaokamentioning

confidence: 99%

“…The gastric mucosa of approximately 50% of the world's population is infected with H. pylori, and the infection levels exceed 70% in some developing areas (14,15). Helicobacter pylori infection plays a crucial role in the development of gastrointestinal diseases, such as peptic ulcer, gastric hyperplastic polyps, gastric adenoma, gastric cancer, and gastric mucosa associated-lymphoid tissue lymphoma, both in individuals with normal renal function and in chronic renal failure patients receiving hemodialysis and CAPD (Tables 1 and 2) (4-9, 16,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]34,[36][37][38][39][40][41][42][43][44][45][47][48][49][50][51][52][53][54][55][56][57][58][59][60].…”

mentioning

confidence: 99%

“…[4][5][6][7][8][9]16,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]34,[36][37][38][39][40][41][42][43][44][45][48][49][50][51][52][53][54][55][56][57][58][59][60], the prevalence of H. pylori infection in patients receiving chronic hemodialysis and CAPD are 43.9% ([95% CI: 42.2-45.6%], 1 435/3 272) and 34.8% ([29.6-40.2%], 113/325), respectively, which is significantly lower than in individuals with normal renal function both with and without gastrointestinal symptoms (49.8% [48.0-51.7%], 1476/2961, P < 0.001).There is variation in H. pylori infection rates among different countries. It may, therefore, be better to evaluate the infection rate in various countries.…”

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confidence: 99%

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Review of Helicobacter pylori Infection and Chronic Renal Failure

Sugimoto

Yamaoka

2010

Ther Apher Dial

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Chronic renal failure patients receiving hemodialysis and continuous ambulatory peritoneal dialysis often encounter gastrointestinal troubles over their long treatment period. Helicobacter pylori infection has close association with development of peptic ulcer, gastric cancer and gastric lymphoma, and is thought to be one of the major risk factors for gastrointestinal troubles in dialysis patients. However, it is unclear whether H. pylori infection is directly associated with progression of renal dysfunction and prognosis of chronic renal failure patients. Recent consensus shows that the prevalence of H. pylori infection in chronic renal failure patients is significantly lower than in subjects with normal renal function. In the natural history of H. pylori infection in hemodialysis patients, the prevalence of infection decreases as dialysis periods progressed, in particular within the first four years after the start of treatment. However, the chance of natural eradication becomes rare for patients receiving dialysis treatment for a long time. Moreover, chronic renal failure patients with H. pylori infection have a higher incidence of gastroduodenal diseases, and therefore, are recommended to receive eradication therapies, especially for those receiving treatment for a long time and with higher risks of complication. Intensive endoscopic check-ups for the prevention of gastrointestinal events and the discovery of peptic ulcer and neoplastic diseases at an early phase may be required.

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“…A detailed description of the method and the formula involved can be found in the paper by Schoenfeld et al [21] and in previous reports [22]. A prevalence of H. pylori of 50% was assumed; and, on the basis of previous reports, it was also estimated that minimal values for sensitivity and specificity were 80% and 80% for serology, and 90% and 90% for UBT [6,7,[11][12][13]19]. Minimal calculated probability of infection after two positive tests was 97.3%.…”

Section: Methodsmentioning

confidence: 99%