Decreased risk of intracerebral hemorrhage among patients with milder allergic rhinitis

Tseng, Chun-Hung; Chen, Jiunn-Horng; Lin, Cheng‐Li; Kao, Chia‐Hung

doi:10.1093/qjmed/hcv104

Cited by 4 publications

(3 citation statements)

References 37 publications

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“…AR), thus they are more often diagnosed with AR. A recent study reported that milder AR correlates with a reduction in the risk of intracranial hemorrhage [ 20 ]. Mediating effects of medical utilization on the association with AR might be attenuated for central obesity due to the difficulty of managing the disease [ 21 ] and for dyslipidemia because it is likely to be clinically overlooked [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Association between allergic rhinitis and metabolic conditions: a nationwide survey in Korea

Hwang

Lee

Ahn

et al. 2016

Allergy Asthma Clin Immunol

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BackgroundAccumulating evidence indicates a strong correlation between allergic disease and cardiovascular risks. In spite of this, the data concerning the association between allergic rhinitis (AR) and cardiovascular risks is sparse and conflicting. This study aimed to investigate the association between AR prevalence and metabolic syndrome (MetS) in a large-scale, population-based survey, while considering the relevant risk factors.MethodsA nationwide cross-sectional study was conducted based on data from 30,590 subjects aged 19 years and older, from the Korean National Health and Nutrition Survey 2007–2013. The odds ratios (ORs) and 95 % confidence intervals (CIs) of AR prevalence, based on MetS status and the presence of any MetS component, were calculated using multiple logistic regression analyses.ResultsRegarding the characteristics of patients with AR and/or MetS, some variables had significant associations with disease in inverse directions for AR and MetS. Multivariate logistic analysis, with adjustments for demographic variables and health habits, indicated that AR prevalence was significantly lower in subjects with MetS (OR 0.84; 95 % CI 0.76–0.93), high blood pressure (OR 0.85; 95 % CI 0.77–0.94), or impaired fasting glucose (OR 0.81; 95 % CI 0.73–0.89). Furthermore, high blood pressure and impaired fasting glucose were significant predictors for reduced AR prevalence, independently of other MetS components.ConclusionIn this population, AR was diagnosed less frequently in subjects with metabolic conditions. Well-designed prospective studies allowing for medical service utilization and collaborative basic research are warranted to elucidate the mechanism responsible for this inverse relationship.

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Section: Discussionmentioning

confidence: 99%

Association between allergic rhinitis and metabolic conditions: a nationwide survey in Korea

Hwang

Lee

Ahn

et al. 2016

Allergy Asthma Clin Immunol

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“…We used the Longitudinal Health Insurance Database (LHID), which consists of 1 million patient data from 1996 to 2000 that were extracted from the catalogue of beneficiaries in the National Health Insurance Research Database (NHIRD). 26 , 28 The NHIRD, which comprises >98% of the population of Taiwan, was established on the basis of the NHI program implemented in 1995. The contents of the LHID include information on patients’ medical registry facilities, their demographic data, and the types of medical care they underwent.…”

Section: Methodsmentioning

confidence: 99%

“… 20 – 22 As reported in previous investigations, type 1 T helper cells (Th1), which are primarily responsible for cellular immunity and enhance the secretion of proinflammatory cytokines, and type 2 T helper cells (Th2), which are responsible for humoral immunity and modulate the functions of Th1, both play a critical role in the immune responses of PID induced by C trachomatis and N gonorrhoeae . 23 – 25 Tseng et al 26 found that a milder form of allergic rhinitis (AR), a Th2-modulated inflammatory disorder, could reduce the risk of ICH, and in an investigation with a short follow-up period (2004–2005), 27 Chen et al found an increased risk of ischemic stroke among patients with PID. However, whether PID, a disease involving the immune response of both Th1 and Th2 cells, advances or attenuates the development of ICH remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Association Between Reduced Risk of Intracerebral Hemorrhage and Pelvic Inflammatory Disease

et al. 2016

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This study examines whether pelvic inflammatory disease (PID) facilitates the development of intracerebral hemorrhage (ICH).By using outpatient claims data from the National Health Insurance Research Database (NHIRD) of Taiwan, we included the data of 25,508 patients who were newly diagnosed with PID between 1999 and 2004, and also from the Taiwan NHIRD, we randomly selected 102,032 women without PID, who were frequency-matched by age and entry-year and with 4 times the number of the PID patients, as the control cohort. We measured ICH risks associated with PID and comorbidities, including hyperlipidemia, diabetes, hypertension, ischemic heart disease, and atrial fibrillation, by the end of 2011.In comparison with the controls, the ICH hazard was less in the PID group with an adjusted hazard ratio (aHR) of 0.67 (95% confidence interval [CI]:0.50–0.90), which was noted by calculation with the Cox proportional regression model. The ICH risk in the PID patients reduced progressively with the advance of age, with aHRs of 0.75 (95% CI:0.41–1.39) and 0.50 (95% CI:0.29–0.88), respectively, in the age <35-year and age ≥50-year groups. ICH risk lowered gradually with the progress of PID severity, from mild PID with an aHR of 0.72 (95% CI:0.53–0.98) to severe PID with that of 0.30 (95% CI:0.10–0.92). PID patients without any comorbidites had lower ICH risk (aHR = 0.63, 95% CI:0.42–0.94) than the controls without any comorbidites did.Our findings revealed that PID is associated with reduced ICH development, especially for older patients.

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Paranasal sinuses opacification on magnetic resonance imaging in relation to brain health in sporadic small vessel disease – Systematic review and pilot analysis

Cortabarria

Zhang

Hernández

et al. 2023

Journal of the Neurological Sciences

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Decreased risk of intracerebral hemorrhage among patients with milder allergic rhinitis

Abstract: This study showed for the first time that milder AR is correlated with a reduction in the risk of ICH, particularly for elderly patients.

Cited by 4 publications

References 37 publications

Association between allergic rhinitis and metabolic conditions: a nationwide survey in Korea

Association between allergic rhinitis and metabolic conditions: a nationwide survey in Korea

Association Between Reduced Risk of Intracerebral Hemorrhage and Pelvic Inflammatory Disease

Paranasal sinuses opacification on magnetic resonance imaging in relation to brain health in sporadic small vessel disease – Systematic review and pilot analysis

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