Decreased retinal sensitivity in depressive disorder: a controlled study

Berman, Galia; Muttuvelu, Danson V; Berman, Dalia Cecilia; Larsen, Jens Ivar; Licht, Rasmus W; Ledolter, Johannes; Kardon, Randy H.

doi:10.1111/acps.12851

Cited by 25 publications

(28 citation statements)

References 35 publications

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“…Melanopsin has been implicated in light-dependant changes in behaviour in rodents 18 reminiscent to depressive states in humans. Decreased retinal light sensitivity assessed by the pupil response was shown for patients with seasonal affective disorder 37 and in patients with non-seasonal depression 8 . The pupil response to light might serve as a marker for identifying persons vulnerable to depression or other diseases where melanopsin is implicated.…”

Section: Discussionmentioning

confidence: 94%

Impact of long-term daylight deprivation on retinal light sensitivity, circadian rhythms and sleep during the Antarctic winter

Kawasaki

Wisniewski

Healey³

et al. 2018

Sci Rep

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Long-term daylight deprivation such as during the Antarctic winter has been shown to lead to delayed sleep timing and sleep fragmentation. We aimed at testing whether retinal sensitivity, sleep and circadian rest-activity will change during long-term daylight deprivation on two Antarctic bases (Concordia and Halley VI) in a total of 25 healthy crew members (mean age: 34 ± 11y; 7f). The pupil responses to different light stimuli were used to assess retinal sensitivity changes. Rest-activity cycles were continuously monitored by activity watches. Overall, our data showed increased pupil responses under scotopic (mainly rod-dependent), photopic (mainly L-/M-cone dependent) as well as bright-blue light (mainly melanopsin-dependent) conditions during the time without direct sunlight. Circadian rhythm analysis revealed a significant decay of intra-daily stability, indicating more fragmented rest-activity rhythms during the dark period. Sleep and wake times (as assessed from rest-activity recordings) were significantly delayed after the first month without sunlight (p < 0.05). Our results suggest that during long-term daylight deprivation, retinal sensitivity to blue light increases, whereas circadian rhythm stability decreases and sleep-wake timing is delayed.

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Section: Discussionmentioning

confidence: 94%

Impact of long-term daylight deprivation on retinal light sensitivity, circadian rhythms and sleep during the Antarctic winter

Kawasaki

Wisniewski

Healey³

et al. 2018

Sci Rep

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“…PIPR measurements have been made in numerous clinical conditions, including multiple sclerosis, Parkinson's disease, idiopathic intracranial hypertension, traumatic brain injury, glaucoma, diabetes, retinitis pigmentosa, Leber's hereditary optic neuropathy, Smith-Magenis syndrome, and depression. 21 – 32 …”

mentioning

confidence: 99%

Pulses of Melanopsin-Directed Contrast Produce Highly Reproducible Pupil Responses That Are Insensitive to a Change in Background Radiance

McAdams

Igdalova

Spitschan

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PurposeTo measure the pupil response to pulses of melanopsin-directed contrast, and compare this response to those evoked by cone-directed contrast and spectrally narrowband stimuli.MethodsThree-second unipolar pulses were used to elicit pupil responses in human subjects across three sessions. Thirty subjects were studied in session 1, and most returned for sessions 2 and 3. The stimuli of primary interest were “silent substitution” cone- and melanopsin-directed modulations. Red and blue narrowband pulses delivered using the post-illumination pupil response (PIPR) paradigm were also studied. Sessions 1 and 2 were identical, whereas session 3 involved modulations around higher radiance backgrounds. The pupil responses were fit by a model whose parameters described response amplitude and temporal shape.ResultsGroup average pupil responses for all stimuli overlapped extensively across sessions 1 and 2, indicating high reproducibility. Model fits indicate that the response to melanopsin-directed contrast is prolonged relative to that elicited by cone-directed contrast. The group average cone- and melanopsin-directed pupil responses from session 3 were highly similar to those from sessions 1 and 2, suggesting that these responses are insensitive to background radiance over the range studied. The increase in radiance enhanced persistent pupil constriction to blue light.ConclusionsThe group average pupil response to stimuli designed through silent substitution provides a reliable probe of the function of a melanopsin-mediated system in humans. As disruption of the melanopsin system may relate to clinical pathology, the reproducibility of response suggests that silent substitution pupillometry can test if melanopsin signals differ between clinical groups.

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“…The yearly onset of SAD symptoms coincides with reductions in the level of ambient light [30], and the disorder is effectively treated with light therapy [31]. Interestingly, persons with SAD have altered retinal light sensitivity including attenuations of the ipRGC-mediated pupillary response to blue light [32][33][34]. In persons with severe visual impairment or blindness, self-reported seasonality is increased in comparison with fully sighted controls [21].…”

Section: Introductionmentioning

confidence: 99%

Mood and behavior seasonality in glaucoma; assessing correlations between seasonality and structure and function of the retinal ganglion cells

et al. 2020

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Decreased retinal sensitivity in depressive disorder: a controlled study

Abstract: The melanopsin-mediated sustained pupil contraction to offset of high-intensity blue light is reduced in depressed patients. These results further emphasize the interaction of light exposure with depression.

Cited by 25 publications

References 35 publications

Impact of long-term daylight deprivation on retinal light sensitivity, circadian rhythms and sleep during the Antarctic winter

Impact of long-term daylight deprivation on retinal light sensitivity, circadian rhythms and sleep during the Antarctic winter

Pulses of Melanopsin-Directed Contrast Produce Highly Reproducible Pupil Responses That Are Insensitive to a Change in Background Radiance

Mood and behavior seasonality in glaucoma; assessing correlations between seasonality and structure and function of the retinal ganglion cells

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