Decreased reactivity to the anticonflict effect of diazepam in perinatally undernourished rats

Brioni, Jorge D.; Córdoba, Nancy E.; Orsingher, Otto A.

doi:10.1016/s0166-4328(89)80099-3

Cited by 24 publications

(5 citation statements)

References 23 publications

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“…40,41 We also know from the work of others that previously malnourished adult rats display reduced behavioral reactions to GABAergic compounds like diazepines. 42 Interestingly, early malnutrition also reduces the brain CSD responses to diazepam, 19 suggesting that the gamma-aminobutyric acid (GABA)-system is modulated by early malnutrition. Based on the present results, we suggest a similar malnutritionrelated modulation on the effects of the opioid system on CSD (note the absence of statistical significance in the CSD velocities of malnourished rats treated with naloxone, as compared with their salinetreated controls, in Fig.…”

Section: Discussionmentioning

confidence: 99%

Early malnutrition attenuates the impairing action of naloxone on spreading depression in young rats

Guedes

Rocha-de-Melo

Lima

et al. 2013

Nutritional Neuroscience

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Section: Discussionmentioning

confidence: 99%

Early malnutrition attenuates the impairing action of naloxone on spreading depression in young rats

Guedes

Rocha-de-Melo

Lima

et al. 2013

Nutritional Neuroscience

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“…Pre-and postnatal malnutrition in rats increase motivation for the consumption of food and water due to a previously imposed deprivation, reduces cognitive flexibility, and causes damage to learning and memory processes in adult animals [15][16][17][18] . Early-malnourished rodents show, later in life, alterations indicative of lowered anxiety-like behavior or increased impulsivity in experimental paradigms such as the light-dark transition test, elevated plus maze, and the elevated T-maze [19][20][21][22] . Specifically, maternal PR results in lower levels of anxiety-like behavior in the elevated plus maze in adult rats [23][24][25] .…”

Section: Introductionmentioning

confidence: 99%

Maternal protein restriction during the lactation period disrupts the ontogenetic development of behavioral traits in male Wistar rat offspring

Oliveira-Silva

Lisboa

Lotufo-Denucci

et al. 2023

J Dev Orig Health Dis

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Neonatal undernutrition in rats results in short- and long-term behavioral and hormonal alterations in the offspring. It is not clear, however, whether these effects are present since the original insult or if they develop at some specific age later in life. Here, we assessed the ontogenetic profile of behavioral parameters associated with anxiety, exploration and memory/learning of Wistar rat offspring that were subjected to protein malnutrition during lactation. Dams and respective litters were separated into two groups: (1) protein-restricted (PR), which received a hypoproteic chow (8% protein) from birth to weaning [postnatal day (PN) 21]; (2) control (C), which received normoproteic chow. Offspring’s behaviors, corticosterone, catecholamines, T3 and T4 levels were assessed at PN21 (weaning), PN45 (adolescence), PN90 (young adulthood) or PN180 (adulthood). PR offspring showed an age-independent reduction in the levels of anxiety-like behaviors in the Elevated Plus Maze and better memory performance in the Radial Arm Water Maze. PR offspring showed peak exploratory activity in the Open Field earlier in life, at PN45, than C, which showed theirs at PN90. Corticosterone was reduced in PR offspring, particularly at young adulthood, while catecholamines were increased at weaning and adulthood. The current study shows that considerable age-dependent variations in the expression of the observed behaviors and hormonal levels exist from weaning to adulthood in rats, and that protein restriction during lactation has complex variable-dependent effects on the ontogenesis of the assessed parameters.

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“…Regarding the functional aspects it has been demonstrated that malnourished-animals submitted to experimental models of anxiety such light -dark transition (Brioni et al 1989;Santucci et al 1994), elevated plus-maze (EPM) 1996b) and elevated T-maze (Almeida et al 1996c;Hernandes and Almeida 2003) showed behavioral alterations that have been interpreted as lower anxiety levels and/or higher impulsiveness. However, little is known about the effects of early protein malnutrition on experimental models of conditioned fear.…”

Section: Introductionmentioning

confidence: 99%

Early postnatal protein malnutrition causes resistance to the anxiolytic effects of diazepam as assessed by the fear-potentiated startle test

Françolin-Silva

Brandão

Almeida

2007

Nutritional Neuroscience

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Given that protein malnutrition induces structural, neurochemical and functional changes in the CNS, the present study aimed to investigate the effects of different early periods of protein malnutrition on the behavior and reactivity to diazepam (DZ) in a model of anxiety: the fear-potentiated startle (FPS). Male Wistar rats (n = 110) from well-nourished (16 %-protein) or malnourished (6%-protein) litters were distributed in five different groups: W (well-nourished), M7 (malnourished for 7-days, since day 0), M14 (14-days), M21 (21-days) and M28 (28-days). The results obtained in FPS revealed that malnourished-animals acquired the startle response, irrespective of the time they were exposed to the diet. Besides, DZ reduced the startle amplitude in the noise-alone and light-noise trials. The data concerning the total freezing time showed that the expression of this response was affected by malnutrition and varied in accordance with the findings of previous studies in which malnutrition procedures was imposed for long periods (more than 50 days). Therefore, we suggest that early protein malnutrition: (a) did not produce deficits in the associative learning process of these animals in the FPS, and (b) decreased freezing time in the FPS and produce hyporeactivity to the effects of DZ in rats malnourished for 21 days or more, indicating alterations in the GABAergic neurotransmitter system.

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Decreased reactivity to the anticonflict effect of diazepam in perinatally undernourished rats

Cited by 24 publications

References 23 publications

Early malnutrition attenuates the impairing action of naloxone on spreading depression in young rats

Early malnutrition attenuates the impairing action of naloxone on spreading depression in young rats

Maternal protein restriction during the lactation period disrupts the ontogenetic development of behavioral traits in male Wistar rat offspring

Early postnatal protein malnutrition causes resistance to the anxiolytic effects of diazepam as assessed by the fear-potentiated startle test

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