Decreased pulmonary capillary volume in adolescents born very preterm

Drummond, David; Hadchouel, Alice; Bourgeois, M. Le; Rozé, Jean Christophe; Marret, Stéphane; Rousseau, Jessica; Ancel, Pierres-Yves; Delacourt, Christophe

doi:10.1111/apa.15023

Cited by 1 publication

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“…Airway versus blood vessel interactions during lung development is poorly understood, and the relative impact from DM and VC for DLCO is therefore of interest [14,[17][18][19]. We aimed to test the hypothesis that impaired DLCO in EP-born subjects persists over time, without age-related catch-up or decline when compared to term-born controls.…”

Section: Introductionmentioning

confidence: 99%

Development of lung diffusion to adulthood following extremely preterm birth

et al. 2021

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BackgroundGas exchange in extremely preterm (EP) infants must take place in foetal lungs. Childhood lung diffusing capacity for carbon monoxide (DLCO) is reduced; however, longitudinal development has not been investigated. We describe growth of DLCO and its sub-components to adulthood in EP-born compared to term-born subjects.MethodsTwo area-based cohorts born at gestational age ≤28 weeks or birth weight ≤1000 grams in 1982–1985 (n=48) and 1991–1992 (n=35) were examined twice, at ages 18 and 25, and 10 and 18 years, respectively, and compared to matched term-born controls. Single-breath DLCO was measured at two oxygen pressures, with sub-components [membrane diffusion (DM) and pulmonary capillary blood volume (VC)] calculated using the Roughton–Forster equation.ResultsAge-, sex- and height-standardized transfer coefficients for carbon monoxide (KCO), and DLCO were reduced in EP-born compared to term-born and remained so during puberty and early adulthood (p-values for all time points and both cohorts ≤0.04), whereas alveolar volume was similar. Development occurred in parallel to term-born controls, with no signs of pubertal catch-up growth nor decline at 25 years (p-values for lack of parallelism within cohorts 0.99, 0.65, 0.71, 0.94, and 0.44 for z-DLCO, z-VA, z-KCO, DM, and VC, respectively). Split by membrane and blood volume components, findings were less clear; however, membrane diffusion seemed most affected.ConclusionPulmonary diffusing capacity was reduced in EP-born compared to term-born, and development from childhood to adulthood tracked in parallel to term-born, with no signs of catch-up growth nor decline at age 25.

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Section: Introductionmentioning

confidence: 99%