Decreased oxidation susceptibility of plasma low density lipoproteins in patients with Gilbert's syndrome

Yeşilova, Zeki; Serdar, Muhittin; Erçin, Cemal Nuri; Günay, Alp; Kılcıler, Güldem; Haşimi, Adnan; Uygun, Ahmet; Kurt, İsmail; Erbil, M.; Dağalp, Kemal

doi:10.1111/j.1440-1746.2008.05388.x

Cited by 39 publications

(28 citation statements)

References 25 publications

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“…As an antioxidant, it has been shown to suppress the oxidation of lipids and lipoproteins, especially LDL cholesterol (5 ), and to be directly related to the total serum antioxidant capacity in humans (4 ). Recent studies indicate that the lipophilic bilirubin is more effective at protecting lipids from oxidation than the water-soluble antioxidants such as glutathione, which primarily protect proteins from oxidation (6 ). Deletion of heme oxygenase-2, which produces biliverdin, in mice was also found to result in greater lipid oxidation than protein oxidation, whereas the reverse was found for glutathione.…”

Section: Biological Properties Of Bilirubinmentioning

confidence: 99%

Serum Bilirubin and Genes Controlling Bilirubin Concentrations as Biomarkers for Cardiovascular Disease

2010

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BACKGROUND: Serum bilirubin has been consistently shown to be inversely related to cardiovascular disease (CVD). Recent studies showed serum bilirubin to be associated with CVD-related factors such as diabetes, metabolic syndrome, and body mass index. Although the association of serum bilirubin with CVD has been found in both retrospective and prospective studies, less information is available on the role of genes that control bilirubin concentrations and their association with CVD.CONTENT: In this review, we provide detailed information on the identity of the major genes that control bilirubin concentrations and their association with serum bilirubin concentrations and CVD risk. We also update the results of the major studies that have been performed on the association between serum bilirubin, CVD, and CVD-related diseases such as diabetes or metabolic syndrome. Studies consistently indicate that bilirubin concentrations are inversely associated with different types of CVD and CVD-related diseases. A conditional linkage study indicates that UGT1A1 is the major gene controlling serum bilirubin concentrations, and this finding has been confirmed in recent genomewide association studies. Studies also indicate that individuals homozygous for UGT1A1*28 have a significantly lower risk of developing CVD than carriers of the wildtype alleles.

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Section: Biological Properties Of Bilirubinmentioning

confidence: 99%

Serum Bilirubin and Genes Controlling Bilirubin Concentrations as Biomarkers for Cardiovascular Disease

2010

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“…The protective effect of increased levels of bilirubin against atherosclerotic heart disease has been reported in many studies (17,18). Bilirubin is known to be a potent antioxidant that decreases lipid peroxidation and the chronic inflammation process (37). Thus, it is known to possess a cardiovascular protective effect.…”

Section: Discussionmentioning

confidence: 99%

The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert`s syndrome: an observational study

Cüre¹,

Çiçek²,

Cüre³

et al. 2013

Anadolu Kardiyol Derg

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Objective: Atherosclerotic heart diseases are less frequently seen in patients with Gilbert's syndrome (GS). We aimed to investigate whether serum adiponectin (APN) and epicardial adipose tissue (EAT) thickness have an effect beside the antioxidant effect of bilirubin in lowering the incidence of the atherosclerotic process. Methods: Sixty-eight patients diagnosed with GS (39 females and 29 males) who had applied at the internal medicine clinic of the hospital were included in this cross-sectional, observational study. The control group included 63 healthy people (39 females and 24 males). EAT thickness was measured by echocardiography. The serum APN levels were also checked. Statistical analysis was performed by using independent sample t-test, Pearson correlation and linear regression analyses. Results: The mean age of the GS group was 28±9 years, and the average EAT thickness was found to be 2.5±0.1 mm. The mean age of the control group was 26±6 years, and the average EAT thickness was found to be 4.2±0.5 mm. When comparing the two groups, the EAT thickness of the GS group was found to be significantly lower (p<0.001) than that of the control group. In the GS group the APN was 14.9±4.2 mg/L, and in the control group the APN was 12.6±4.5 mg/L (p<0.022). We found that total bilirubin (β=-1,607, p<0,001) and indirect bilirubin (β=1,086, p<0,001) have an independent association with decreased EAT thickness. Conclusion: EAT thickness is associated with coronary atherosclerosis. Low EAT thickness may be related with low release of proinflammatory cytokine. High levels of APN may be related high anti-inflammatory effect. Therefore, low EAT thickness and high levels of APN may demonstrate protective effect on atherosclerotic heart diseases in GS patients. (

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“…It has been found that serum bilirubin level is inversely related to insulin resistance, serum insulin, triglyceride, systolic blood pressure, apolipoprotein B and obesity 53,83,84 . Even though the incidence of cholelithiasis in GS patients has been reported to be high, this increase is more prominent in concomitant conditions like cystic fibrosis, hereditary spherocytosis and sickle cell anemia [85][86][87] .…”

Section: Gs and Other Metabolic Conditionsmentioning

confidence: 99%

“…In patients with GS the low levels of LDL and CRP indicate low oxidative stress, strong capacity of antioxidation and low inflammation process. Indeed, previous studies have shown indirect bilirubin to be protective against lipid peroxidation and as a remover of peroxide radicals 52,53 .…”

Section: Gs Reduces the Risk Of Heart Diseasementioning

confidence: 99%

Gilbert\\\\\\\'s Sendromu

Cüre¹,

Yüce²,

Cüre³

2014

Arşiv Kaynak Tarama Dergisi

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Gilbert's syndrome is a benign condition that does not progress to chronic liver disease or fibrosis. Gilbert's syndrome diagnosis should be considered in patients with chronic elevation of unconjugated bilirubin. In these patients the presence of hemolysis and other diseases of the liver should be excluded. Gilbert's syndrome is an autosomal recessive disease. The mutation of uridine diphosphate glucuronyl transferase is seen in 10-16% of the population. There is a 70-80% decrease in bilirubin glucuronidation. In cases of unexplained indirect hyperbilirubinemia with no history of drugs, smoking or alcohol use, Gilbert's syndrome should be considered. Firstly, hemolysis should be excluded. It has been reported that having increased levels of indirect bilirubin lowers the incidence of carotid plaque and coronary artery disease in patients with Gilbert's syndrome. The antioxidation and resistance to oxidative stress status of patients with Gilbert's syndrome is known to be high. However, Gilbert's syndrome is associated with breast and colon cancer. Several studies have reported that liver transplantation from a patient with Gilbert's syndrome had no harm to himself or to the recipient. An exact relationship between schizophrenia and Gilbert's syndrome has not been demonstrated. Gilbert's syndrome patients have a risk of breast and colon cancer so frequent follow up is recommended.

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Decreased oxidation susceptibility of plasma low density lipoproteins in patients with Gilbert's syndrome

Abstract: It is suggested that the chronic hyperbilirubinemia leading to a lag-phase prolongation in LDL oxidation and a decrease in LDL oxidation may be reason for the low percentage of coronary artery disease.

Cited by 39 publications

References 25 publications

Serum Bilirubin and Genes Controlling Bilirubin Concentrations as Biomarkers for Cardiovascular Disease

Serum Bilirubin and Genes Controlling Bilirubin Concentrations as Biomarkers for Cardiovascular Disease

The evaluation of relationship between adiponectin levels and epicardial adipose tissue thickness with low cardiac risk in Gilbert`s syndrome: an observational study

Gilbert\\\\\\\'s Sendromu

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