Gilbert\\\\\\\'s Sendromu

Abstract

Gilbert's syndrome is a benign condition that does not progress to chronic liver disease or fibrosis. Gilbert's syndrome diagnosis should be considered in patients with chronic elevation of unconjugated bilirubin. In these patients the presence of hemolysis and other diseases of the liver should be excluded. Gilbert's syndrome is an autosomal recessive disease. The mutation of uridine diphosphate glucuronyl transferase is seen in 10-16% of the population. There is a 70-80% decrease in bilirubin glucuronidation. In cases of unexplained indirect hyperbilirubinemia with no history of drugs, smoking or alcohol use, Gilbert's syndrome should be considered. Firstly, hemolysis should be excluded. It has been reported that having increased levels of indirect bilirubin lowers the incidence of carotid plaque and coronary artery disease in patients with Gilbert's syndrome. The antioxidation and resistance to oxidative stress status of patients with Gilbert's syndrome is known to be high. However, Gilbert's syndrome is associated with breast and colon cancer. Several studies have reported that liver transplantation from a patient with Gilbert's syndrome had no harm to himself or to the recipient. An exact relationship between schizophrenia and Gilbert's syndrome has not been demonstrated. Gilbert's syndrome patients have a risk of breast and colon cancer so frequent follow up is recommended.

Protective effect of aqueous leaf extracts of Chromolaena odorata and Tridax procumbens on doxorubicin-induced hepatotoxicity in Wistar rats

“… 87 Therefore, sequel to the antioxidant property of bilirubin, 88 – 90 and its ability to function as a cellular antioxidant, 86 , 91 epidemiological studies have shown that levels of plasma bilirubin are inversely correlated with the risk for the development and progression of both chronic kidney disease and cardiovascular disease. 88 , 89 , 90 , 92 – 96 Therefore, in the absence of liver disease, high levels of total bilirubin, as observed in this study, may confer some health benefits. 92 , 95 , 97 …”

Serum Bilirubin Levels and the Presence and Progression of Abdominal Aortic Aneurysms

“…21 Gilbert syndrome is an autosomal recessive hereditary disease, which is characterized by raised serum indirect bilirubin levels. 22 There is less incidence of atherosclerotic cardiovascular disease in patients with GS, and for these patients, increased bilirubin levels are shown to be negatively correlated with aortic stiffness. 23 In our study, we did not investigate a diagnosis of GS in the patients.…”