Decreased microRNA-30a levels are associated with enhanced ABL1 and BCR-ABL1 expression in chronic myeloid leukemia

Liu, Yue; Song, Yong; Ma, Wenxue; Wen-ling, Zheng; Yin, Hong

doi:10.1016/j.leukres.2012.12.003

Cited by 45 publications

(26 citation statements)

References 25 publications

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“…Interestingly, the expression of miR30a decreases with the progression of lymphoma, leukemia, lung, ovarian, breast and colon cancer (Cheng et al, 2012;González-Gugel et al, 2013;Guan et al, 2012;Lee et al, 2012;Liu et al, 2013;Ma et al, 2012;Võsa et al, 2013), all cancers in which SIX1 overexpression has been detected (Behbakht et al, 2007;Ford et al, 1998;Mimae et al, 2012;Ono et al, 2012;Wang et al, 2011). Importantly, increased SIX1 expression enhances progression of RMS and several additional tumor types by re-activating many of the same signaling networks that SIX1 turns on developmentally to promote cell survival, proliferation and migration (Christensen et al, 2008;Khan et al, 1999;Yu et al, 2006;Yu et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-30a regulates zebrafish myogenesis via targeting the transcription factor Six1

O’Brien

Hernandez-Lagunas

Artinger

et al. 2014

Journal of Cell Science

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Precise spatiotemporal regulation of the SIX1 homeoprotein is required to coordinate vital tissue development, including myogenesis. Whereas SIX1 is downregulated in most tissues following embryogenesis, it is re-expressed in numerous cancers, including tumors derived from muscle progenitors. Despite crucial roles in development and disease, the upstream regulation of SIX1 expression has remained elusive. Here, we identify the first direct mechanism for Six1 regulation in embryogenesis, through microRNA30a (miR30a)-mediated repression. In zebrafish somites, we show that miR30a and six1a and six1b (hereafter six1a/b) are expressed in an inverse temporal pattern. Overexpression of miR30a leads to a reduction in six1a/b levels, and results in increased apoptosis and altered somite morphology, which phenocopies six1a/b knockdown. Conversely, miR30a inhibition leads to increased Six1 expression and abnormal somite morphology, revealing a role for endogenous miR30a as a muscle-specific miRNA (myomiR). Importantly, restoration of six1a in miR30a-overexpressing embryos restores proper myogenesis. These data demonstrate a new role for miR30a at a key node in the myogenic regulatory gene network through controlling Six1 expression.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-30a regulates zebrafish myogenesis via targeting the transcription factor Six1

O’Brien

Hernandez-Lagunas

Artinger

et al. 2014

Journal of Cell Science

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“…Furthermore, miR-29b and miR-196b are reduced in CML patients and can target ABL11, BCR-ABL11 and HOXA9 [17,18]. Downregulation of miR-30a and miR-138 is associated with overexpression of BCR-ABL11 in CML patients [19,20]. MiRNA profiling has been performed using microarrays for CML, and deregulation of some miRNAs has been indicated in patients with CML.…”

Section: Introductionmentioning

confidence: 99%

Expression pattern of key microRNAs in patients with newly diagnosed chronic myeloid leukemia in chronic phase

Fallah

Amirizadeh

Poopak

et al. 2015

Int J Lab Hematology

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“…In chronic myeloid leukemia (CML), miR-30a reduced ABL1 and BCR-ABL1 protein expression, and acted as an onco-suppressor via inhibition of cell proliferation [105]. …”

Section: Activities Of Mir-30a In Cancer Progressionmentioning

confidence: 99%

The Versatile Role of microRNA-30a in Human Cancer

Xiang

Chen²,

Chen³

2017

Cell Physiol Biochem

2,603

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MicroRNAs (miRNAs) are a group of noncoding RNA molecules of 20-23 nucleotides length that negatively regulate gene expressions in numerous cellular processes. Through complementary paring with target mRNAs, miRNAs have frequently emerged as dual regulators of cancer development by acting on multiple signaling pathways, thereby act as novel biomarkers for cancer diagnosis, prognosis, and prediction of response to treatment. As one of them, miR-30a has been found to act as an onco-suppressor of tumorigenesis pathways through inhibition of cellular proliferation, migration and invasion. Simultaneously, miR-30a plays a progressing role in several types of cancer, determined by relevant target genes as well. In the present review, we summarize recent research regarding miR-30a, including its biological function, expression and regulation, especially focusing on its role in cancer development and progression. Clinically, miR-30a may serve as a potential target in the diagnosis and therapy of human cancer.

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Decreased microRNA-30a levels are associated with enhanced ABL1 and BCR-ABL1 expression in chronic myeloid leukemia

Cited by 45 publications

References 25 publications

MicroRNA-30a regulates zebrafish myogenesis via targeting the transcription factor Six1

MicroRNA-30a regulates zebrafish myogenesis via targeting the transcription factor Six1

Expression pattern of key microRNAs in patients with newly diagnosed chronic myeloid leukemia in chronic phase

The Versatile Role of microRNA-30a in Human Cancer

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