Decreased levels of IGF binding protein-3 in serum from children with Perthes’ disease

Matsumoto, Tomoko; Enomoto, Hiroshi; Takahashi, Kazuhiro; Motokawa, Satoru

doi:10.3109/17453679809117611

Cited by 18 publications

(9 citation statements)

References 15 publications

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“…IGFBP-3 was normal, which also agrees with some (Neidel et al 1993, Grasemann et al 1996 but not other (Matsumoto et al 1998) reports.…”

Section: Discussionsupporting

confidence: 80%

“…The bioactivity of circulating IGF-I at target tissue level is, in turn, modulated by its main binding protein, IGFBP-3, and protease activity. There have been conflicting reports regarding circulating levels of IGF-I and IGFBP-3 in children with Perthes' disease (Neidel et al 1992a, b, 1993, Grasemann et al 1996, Matsumoto et al 1998). In addition to hormonal influences, bone growth may be influenced directly by mechanical factors (Golding 1994).…”

mentioning

confidence: 99%

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Children with acute Perthes' disease have asymmetrical lower leg growth and abnormal collagen turnover

Crofton¹,

Macfarlane²,

Wardhaugh³

et al. 2005

Acta Orthopaedica

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Background Abnormalities in distal growth and low levels of insulin-like growth factor (IGF)-I have been reported in children with Perthes' disease. Our aim was to establish whether the acute phase of Perthes' disease is associated with abnormalities of growth, of bone or of collagen turnover.Methods We performed a cross-sectional study of 15 children (3-11 years of age, 13 boys) at acute presentation and a longitudinal cohort study of 9 children. We measured (1) the lengths of both lower legs (by knemometry) at weeks 1, 2, 6 and 12, (2) height and weight at presentation and at the second-year follow-up, and (3) levels of IGF-I, IGFBP-3, collagen markers and bone alkaline phosphatase at weeks 1 and 12, and in year 2.Results Height SD scores were normal at presentation but declined thereafter. Lower leg growth was not impaired at presentation but was asymmetrical, ceased during weeks 2-6, and then resumed symmetrically. Patients had persistently low IGF-I, low soft tissue collagen synthesis and enhanced collagen breakdown compared with age-and sex-related reference data. Markers of bone formation increased during follow-up.Interpretation Acute changes in lower leg growth reflected differential weight bearing, then immobilization and remobilization. Persistently low IGF-I may have contributed to low soft tissue collagen synthesis and growth. Changes in bone formation markers most likely reflected bone healing.

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“…IGFBP-3 was normal, which also agrees with some (Neidel et al 1993, Grasemann et al 1996 but not other (Matsumoto et al 1998) reports.…”

Section: Discussionsupporting

confidence: 80%

mentioning

confidence: 99%

Children with acute Perthes' disease have asymmetrical lower leg growth and abnormal collagen turnover

Crofton¹,

Macfarlane²,

Wardhaugh³

et al. 2005

Acta Orthopaedica

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“…In plasma, nearly all the IGF-1 is bound to specific binding proteins, which for IGF-1 is the IGF-binding protein 3 (IGFBP3). Decreased levels of IGFBP in children with LCPD have been seen but with normal levels of IGF-1 [90]. No abnormalities in IGF-1 or IGFBP concentrations have been encountered by others [68, 83, 91, 92] in children with LCPD.…”

Section: Resultsmentioning

confidence: 99%

The Epidemiology and Demographics of Legg-Calvé-Perthes' Disease

Loder

Skopelja

2011

ISRN Orthopedics

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The etiology of Legg-Calvé-Perthes' disease (LCPD) is unknown. There are many insights however from epidemiologic/demographic information. A systematic medical literature review regarding LCPD was performed. The incidence ranges from 0.4/100,000 to 29.0/100,000 children <15 years of age. There is significant variability in incidence within racial groups and is frequently higher in lower socioeconomic classes. The typical age at presentation ranges from 4 to 8 years (average 6.5 years), except for children from the Indian subcontinent (average 9.5 years). There is a mild familial component. The children demonstrate impaired growth in height, skeletal age, and birth weight. This impaired growth coincides with an age appropriate reduced somatomedin A activity and decreased levels of IGF. LCPD can be associated with abnormalities in the coagulation cascade, including an increase in factor V Leiden mutation, low levels of protein C and/or S, and decreased antithrombin activity. There is decreased turnover in type I collagen and synthesis of type III collagen, as well as reduced levels of urinary glycosaminoglycans in the active phases of the disorder. Subtle abnormalities in the opposite hip and other minor/major congenital defects are reported. Children with LCPD are active and score abnormally in certain standardized psychological tests.

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“…18,19 These results conflict with another study, which reported normal IGF-1 binding protein levels. Thus, dysfunction in the IGF-1 pathway can potentially explain the delayed skeletal maturation, hyperactive behavior, and minor congenital abnormalities seen in the patients with LCPD.…”

Section: Abnormality In the Insulin-like Growth Factor-1 Pathwaymentioning

confidence: 62%

Legg-Calve-Perthes Disease

Kim

2011

Journal of Pediatric Orthopaedics

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Legg-Calve-Perthes disease is a complex pediatric hip disorder with many uncertainties. Various theories on its etiology have been proposed but none have been validated conclusively. Through experimental studies, however, some insight into the pathogenesis of a femoral head deformity after ischemic necrosis has been gained. These studies reveal that mechanical and biological factors contribute to the development of the femoral head deformity. Better understanding of the pathobiology of Legg-Calve-Perthes disease will lead to the development of more effective treatments, which are able to specifically target the pathogenic processes.

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Decreased levels of IGF binding protein-3 in serum from children with Perthes’ disease

Cited by 18 publications

References 15 publications

Children with acute Perthes' disease have asymmetrical lower leg growth and abnormal collagen turnover

Children with acute Perthes' disease have asymmetrical lower leg growth and abnormal collagen turnover

The Epidemiology and Demographics of Legg-Calvé-Perthes' Disease

Legg-Calve-Perthes Disease

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