Decreased levels of circulating CD4+ T lymphocytes during normal human pregnancy

Castilla, J. Pérez; Rueda, Ricardo; Vargas, M L; González‐Gómez, Francisco; Olivares, Enrique G.

doi:10.1016/0165-0378(89)90030-2

Cited by 63 publications

(8 citation statements)

References 21 publications

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“…The rise in decidual T cells may be related to the variations in peripheral blood T cell proportions during pregnancy. 12 We did not study CD4 and CD8 expression by the early decidual lymphocytes with flow cytometry; however, Sato et al 13 observed significant proportions of CD3 + , CD4 + , and CD8 + lymphocytes.…”

Section: Discussionmentioning

confidence: 87%

Comparison of the Proportions of Leukocytes in Early and Term Human Decidua

Vargas¹,

Santos²,

Ruíz³

et al. 1993

American J Rep Immunol

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The percentages of cells expressing immune markers were determined with immunohistochemistry and flow cytometry in early and term human decidua. Although we found no variation in the proportion of cells of bone marrow origin (CD45+), the percentages of T cells and CD16+ lymphocytes were significantly higher in term decidua. On the contrary, CD56+ lymphocytes, the most abundant leukocyte type in early decidua, decreased at term. These variations may reflex the immunological adaptations of decidua during pregnancy.

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Section: Discussionmentioning

confidence: 87%

Comparison of the Proportions of Leukocytes in Early and Term Human Decidua

Vargas¹,

Santos²,

Ruíz³

et al. 1993

American J Rep Immunol

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“…For instance, pregnant women have an increased risk of influenza [42] and a decreased CD4:CD8 cell ratio [43][44][45]. Pregnant women with HIV infection experience elevations in T lymphocytes of the CD45RO phenotype and reductions in T lymphocytes of the naive phenotype; they also have an increase in the proportion of CD4 ϩ DR ϩ CD38 ϩ cells and reduced capacity for interleukin-2 production [46].…”

Section: Discussionmentioning

confidence: 98%

Longitudinal and Cross‐Sectional Analysis of Cytotoxic T Lymphocyte Responses and Their Relationship to Vertical Human Immunodeficiency Virus Transmission

Jin

Cg²,

Nixon³

et al. 1998

J INFECT DIS

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The ARIEL Project for the Prevention of HIV Transmission from Mother to Infant was established to evaluate virologic and immunologic parameters during vertical transmission. To determine the strength and breadth of the cytotoxic T lymphocyte (CTL) response and its correlation with human immunodeficiency virus (HIV) transmission, a cross-sectional study was done of 31 HIV-infected pregnant women, of whom 15 transmitted and 16 did not transmit HIV to their infants. The precursor frequencies of CTL specific for HIV-1 gag, pol, nef, and env from 5 different isolates of the clade B of HIV-1 were determined by limiting dilution analysis. Results showed that variable levels of HIV-specific CTL response were present in HIV-infected pregnant women during and after pregnancy. In addition, CTL precursor frequencies specific for pol and nef were higher during pregnancy in nontransmitters than in transmitters. Thus, CTL responding to different HIV antigens may not be contributing equally to the prevention of vertical transmission.

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“…Pregnancy is characterized by profound changes in hormone levels that can have specific and nonspecific effects on the immune system. A decrease in peripheral blood lymphocytes in early pregnancy has been observed consistently (76).…”

Section: Factors That May Affect the Immune Responsementioning

confidence: 97%

Approaches to Detecting Immunotoxic Effects of Environmental Contaminants in Humans

Tryphonas¹

2001

Environmental Health Perspectives

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Decreased levels of circulating CD4+ T lymphocytes during normal human pregnancy

Cited by 63 publications

References 21 publications

Comparison of the Proportions of Leukocytes in Early and Term Human Decidua

Comparison of the Proportions of Leukocytes in Early and Term Human Decidua

Longitudinal and Cross‐Sectional Analysis of Cytotoxic T Lymphocyte Responses and Their Relationship to Vertical Human Immunodeficiency Virus Transmission

Approaches to Detecting Immunotoxic Effects of Environmental Contaminants in Humans

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