Decreased gray matter volume of the anterior insular cortex in patients with psychogenic erectile dysfunction: A voxel-based morphometry study

Ma, Ziyang; Ren, Feiqiang; Huang, Xiaopeng; Yang, Xuemei; Li, Hao; Li, Guangsen; Chang, Degui; Yin, Tao; Zhang, Peihai

doi:10.1016/j.jpsychires.2021.12.006

Cited by 4 publications

(6 citation statements)

References 41 publications

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“…An external constriction ring is placed at the base of the penis to prevent blood flow during intercourse in order to maintain an erection, but the ring should not be placed for more than half an hour (Yuan et al, 2010;Lin and Wang, 2013). It is used to promote the recovery of penis function and maintain penis length (Ma et al, 2021). Animal experiment by Ma et al had demonstrated that the erectile response induced by the vacuum erection device may increase the smooth muscle/collagen ratio by decreasing hypoxia-inducible factor-1 and transforming growth factor-1, thereby improving penile blood flow (Yuan et al, Frontiers in Physiology frontiersin.org 05 Pang et al 10.3389/fphys.2022Pang et al 10.3389/fphys.…”

Section: Vedmentioning

confidence: 99%

Metabolic Factors in Erectile Dysfunction

Meng,

Rao,

Chen

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Section: Vedmentioning

confidence: 99%

Metabolic Factors in Erectile Dysfunction

Meng,

Rao,

Chen

2024

Frontiers Research Topics

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“…8 Previous studies also reported changed brain dynamics in this region in pED patients. 37,59 Specifically, this region integrates the re-represented interceptive signals passed on from the posterior INS with emotional, cognitive, and motivational signals collected from other cortical and subcortical regions, 60 and determines subjective sensory state in the sexual appraisal. 9,61…”

Section: Abnormal Neural Network Of Appraisal In Psychogenic Erectile...mentioning

confidence: 99%

Identifying neuroimaging biomarkers for psychogenic erectile dysfunction by fusing multi‐level brain information: A resting‐state functional magnetic resonance imaging study

et al. 2022

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Background: Psychogenic erectile dysfunction (pED) patients who are under their 40s in China consist of a major component of erectile dysfunction. Existing neuroimaging studies have demonstrated that pED is a functional disorder with aberrant neural representations on the local level, the regional level, and the global level, respectively. Therefore, it is reasonable to incorporate brain information from all these levels simultaneously into consideration when identifying neuroimaging biomarkers for pED.However, no such endeavors have been made in previous studies to fully disclose the central mechanism of pED. Method:To incorporate multi-level brain features to fully explore the neural representation of pED, a novel machine learning framework was proposed in the current study. Specifically, we used amplitude of low-frequency fluctuation, regional homogeneity, and degree centrality as indices for local, regional, and global brain activity, respectively. A fully data-driven method, that is, support vector machine (SVM) with recursive feature elimination analyses, was used to investigate discriminative brain map between 48 pED patients and 39 healthy control subjects for resting state functional magnetic resonance imaging (rs-fMRI) data. Results:By fusing multi-level brain features, our method led to a superb classification accuracy of 95.12% between two groups. Interestingly, the right anterior cingulate gyrus and the left precuneus showed abnormal representations at different levels

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“…Psychogenic ED (pED) is a primary subtype of ED caused by mental and psychosocial factors, which is diagnosed in the exclusion of organic factors and has severe impacts on the overall psychological health and quality of life (QOL) of patients and their partners (2). It even brings huge socio-economic burdens (3). ED is highly prevalent in modern societies, affecting approximately 30% of young men (4).…”

Section: Introductionmentioning

confidence: 99%

“…pED patients account for 73.6% of ED patients under 40 years old in China (5). In recent years, pED has been the focus of researchers due to its extreme importance and high incidence (3).…”

Section: Introductionmentioning

confidence: 99%

Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in patients with psychogenic erectile dysfunction

Chen

et al. 2023

Front. Endocrinol.

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BackgroundPsychological stress and its two stress response systems, the hypothalamic-pituitary-adrenal (HPA) axis and the autonomic nervous system (ANS), are closely related to psychogenic erectile dysfunction (pED). However, the analyses of perceived stress and stress systems in pED patients need to be more in-depth, especially the interactions between them.MethodsOur study included 75 patients with pEDs and 75 healthy men. The International Index of Erectile Function-5 (IIEF-5) and the 10-item Perceived Stress Scale (PSS-10) were used for assessing the severity of ED and perceived stress. All participants collected saliva samples on three consecutive days at eight specific times with strict reference to the time of morning awakening for measuring cortisol parameters and wore electrocardiography for 24 h to derive heart rate variability (HRV).ResultsThe PSS-10 scores of pED patients were significantly higher than the control group (p<0.001). Although PSS-10 and IIEF-5 scores were negatively correlated in pED patients, there was no statistical significance between them (r=−0.049, p=0.677). Compared with the control group, the HRV parameters of pED patients were significantly increased in LF/HF ratio (p=0.014) but significantly decreased in LF, HF, and pNN50 (p<0.001). However, the two groups had no statistically significant differences in cortisol variables (all p>0.05). The interaction between sympathovagal modulation (HF, rMSSD) and cortisol awakening response (CAR AUCi) explained significantly greater variance in perceived stress than either stress system alone. Higher parasympathetic activity combined with a higher cortisol awakening response was associated with greater perceived stress.ConclusionOur results suggested that the interrelation between ANS and HPA axis activity might enhance our comprehension of how stress affected the physical and mental health of pED patients.

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Decreased gray matter volume of the anterior insular cortex in patients with psychogenic erectile dysfunction: A voxel-based morphometry study

Cited by 4 publications

References 41 publications

Metabolic Factors in Erectile Dysfunction

Metabolic Factors in Erectile Dysfunction

Identifying neuroimaging biomarkers for psychogenic erectile dysfunction by fusing multi‐level brain information: A resting‐state functional magnetic resonance imaging study

Hypothalamic-pituitary-adrenal axis activity and its relationship to the autonomic nervous system in patients with psychogenic erectile dysfunction

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