Decreased dentin tubules density and reduced thickness of peritubular dentin in hyperbilirubinemia-related green teeth

Silva, Rodrigo Neves; Alves, Fábio Abreu; Antunes, Alberto Nogueira da Gama; Góes, Mário Fernando de; Giannini, Marcelo; Tenório, Maria Cristina; Machado, José Lécio; Paes-Leme, Adriana Franco; Lopes, Márcio Ajudarte; Santos‐Silva, Alan Roger

doi:10.4317/jced.53490

Cited by 6 publications

(5 citation statements)

References 23 publications

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“…The density of dentinal tubules might be influenced by preexisting conditions, such as hyperbilirubinemia [ 21 ], by adhesion techniques used for composite materials [ 22 ] or by using arginine-containing dentifrice that would obliterate them to help patients with dentin hypersensitivity [ 23 , 24 ].…”

Section: ⧉ Discussionmentioning

confidence: 99%

A software approach for identifying the effect of dental caries on dentin–enamel junction

Gălbinașu

Pharmacy²,

Manolea³

et al. 2021

Rom J Morphol Embryol

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Dental decay is the most prevalent oral disease worldwide since more than 2.4 billion people suffer from caries of permanent teeth. Therefore, any details about its progression into the hard-dental tissues could contribute to unravelling the mechanisms underlying this process. We have analyzed dental tissue sections with and without caries in order to detect structure differences corelating them with clinical aspects observable from the tooth surface. Our working hypothesis was based on finding a link between the process of tertiary dentin laying (as a response to coronal caries) and the subsequent obliteration of dentin tubules. We have selected N=10 extracted teeth with/without coronal caries, resin-embedded and sectioned them. A specific software was used to digitally quantify the density of unobliterated dentin tubules reaching the dentin-enamel junction (DEJ), considering as positive threshold criteria the presence of the odontoblast process inside the analyzed tubule. This study showed the differences between the healthy and carious-affected hard-dental coronal tissues. More odontoblast processes reached the DEJ in unaffected teeth. Using specific software, we have quantified their density decrease near a lesion. We have studied the dynamics of the carious study and measured the consequent structural modifications of the dentin. In conclusion, there is a significant difference between the number of dentin tubules containing odontoblast processes that reach the DEJ in healthy/altered tissues. The tooth reacts not only by production of tertiary dentin to protect the pulp chamber, but also by obliteration of dentin tubules, thus reducing the number of odontoblast processes reaching the DEJ. This pilot study could serve as the starting point in developing a dedicated software that could deliver a personalized pattern for decay progression by analyzing one single tooth and extrapolate the result to all the patient's remaining ones.

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Section: ⧉ Discussionmentioning

confidence: 99%

A software approach for identifying the effect of dental caries on dentin–enamel junction

Gălbinașu

Pharmacy²,

Manolea³

et al. 2021

Rom J Morphol Embryol

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“…4 Neves-Silva et al demonstrated that hyperbilirubinemia led to a decrease in the density of the dentin tubules in the patients' green teeth. 33 The diagnosis of bilirubin pigmentation is usually based on a clinical history of jaundice combined with green tooth discoloration and, less often, enamel hypoplasia. 9,11 The differential diagnosis of green teeth includes extrinsic discolorations caused by chromogenic bacteria or medications, and intrinsic pigmentation has been reported in patients with developmental anomalies, such as dentinogenesis imperfecta and amelogenesis imperfecta.…”

Section: Discussionmentioning

confidence: 99%

“…This change in the dental structure can change the performance of the adhesive materials that are influenced by structural characteristics, such as diameter and number of dentinal tubules per mmš, relative amount of peritubular dentin and intertubular dentin. 33 As a consequence, the bonding of brackets during orthodontic treatment and even dental bonding and adhesion of porcelain veneers and dental crowns during cosmetic dental treatment may be compromised or present flaws in ALGS patients who have greenish/brownish intrinsic discoloration, enamel opacities, hypomineralization, and hypoplasia of tooth enamel.…”

Section: Management Of Dental Care For Patients With Algsmentioning

confidence: 99%

Alagille syndrome: Oral manifestations—A case report

Anacleto

Melo

Oliveira

et al. 2021

Special Care in Dentistry

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The Alagille syndrome (AGLS) is a rare condition, with few studies reported in the literature, especially in the field of dentistry. It consists of a disease involving many systemic problems and specific facial features. The liver and heart are the most intensely affected organs, and depending on the severity, it may be necessary to perform transplants. It is an autosomal dominant disease with a variable expressivity, and its prevalence is 1/100,000 live births. Dental findings are conflicting. Some authors claim that dental anomalies occur only in deciduous dentitions; however, there is evidence that permanent teeth can also be affected, as will be described in this paper, through a case report of a patient diagnosed with AGLS, who sought out the Dentistry service at Pontifical Catholic University of Minas Gerais, complaining of a strong stain in her teeth, severe dental crowding, and a facial appearance of prognathism.

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“…Oral findings may be related to anemia and vitamin deficiencies; these findings are; glossitis, angular cheilitis, and mucosal pallor [26]. Neves-Silva et al [31] demonstrated a correlation between childhood hyperbilirubinemia and changes in the dentin morphology, including a decrease in the density of the dentin tubules and a reduction in the thickness of peritubular dentin in green teeth.…”

Section: Diseases Of the Hepatobiliary Systemmentioning

confidence: 99%

Oral Diseases Associated with Gastrointestinal Disorders

Bıçak¹,

Akyüz²

2018

Gastroint Hepatol Dig Dis

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Dentistry is a branch of medicine that focuses on the health status of the oral cavity, it also strongly integrates with other areas of medicine, as the health of the oral cavity may influence the health condition of other organs of the body. The gastrointestinal system, in particular, can be influenced by the oral cavity, as the oral cavity serves as an initial entrance to the gastrointestinal tract. Oral and gastrointestinal diseases can affect each other. The major role of the oral cavity is biting, chewing and mixing of food particles with saliva to form 'bolus' ready for swallowing and passing through the pharynx and the esophagus to the stomach. Dentists and gastroenterologists anticipated to recognize and diagnose oral and gastric conditions associated with gastrointestinal system beginning from the oral cavity. The aim of the current review is to describe the oral manifestations of gastrointestinal (GI) diseases which are important in the screening of GI disorders which may otherwise be undiagnosed. The review includes peptic ulcer diseases, gastroesophageal reflux disease, coeliac disease, Inflammatory bowel diseases and syndromes affecting both the GI system and oral cavity.

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Decreased dentin tubules density and reduced thickness of peritubular dentin in hyperbilirubinemia-related green teeth

Cited by 6 publications

References 23 publications

A software approach for identifying the effect of dental caries on dentin–enamel junction

A software approach for identifying the effect of dental caries on dentin–enamel junction

Alagille syndrome: Oral manifestations—A case report

Oral Diseases Associated with Gastrointestinal Disorders

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