Decreased cpg15 augments oxidative stress in sleep deprived mouse brain

Li, Cheng-Jing; Li, Junjie; Jiang, Yi; Mu, Ya-Wei; Lu, De-Xin; Xiao, Zi-Yao; Jiang, Huai; Zhao, Jingjing; Chen, Xianhua

doi:10.1016/j.bbrc.2019.11.132

Cited by 5 publications

(5 citation statements)

References 37 publications

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“…An animal study showed that REM sleep deprivation could induce endothelial dysfunction and hypertension through the endothelial NO synthase pathway (38). Some animal studies also showed that REM sleep deprivation could create oxidative stress and reactive oxygen species which may contribute to endothelial dysfunction (39,40).…”

Section: Discussionmentioning

confidence: 99%

Endothelial Function and Arterial Stiffness Should Be Measured to Comprehensively Assess Obstructive Sleep Apnea in Clinical Practice

Luo

Wang

Guo

et al. 2021

Front. Cardiovasc. Med.

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Objective: An effective clinical tool to assess endothelial function and arterial stiffness in patients with obstructive sleep apnea (OSA) is lacking. This study evaluated the clinical significance of subclinical markers for OSA management in males without serious complications.Patients/Methods: Males without serious complications were consecutively recruited. Clinical data, biomarker tests, reactive hyperemia index (RHI), and augmentation index at 75 beats/min (AIx75) measured by peripheral arterial tonometry were collected. An apnea hypopnea index (AHI) cutoff of ≥15 events/h divided the patients into two groups.Results: Of the 75 subjects, 42 had an AHI ≥15 events/h. Patients with an AHI ≥15 events/h had higher high-sensitivity C-reactive protein, tumor necrosis factor-alpha (TNF-α), vascular endothelial growth factor, and AIx75 values than the control group but no statistical difference in RHI was observed. After controlling for confounders, TNF-α was negatively correlated with the average oxygen saturation (r = −0.258, P = 0.043). RHI was correlated with the rapid eye movement (REM) stage percentage (r = 0.306, P = 0.016) but not with AHI (P > 0.05). AIx75 was positively correlated with the arousal index (r = 0.289, P = 0.023) but not with AHI (r = 0.248, P = 0.052).Conclusions: In males with OSA without severe complications, TNF-α and AIx75 are independently related to OSA. The role of RHI in OSA management requires further elucidation. These markers combined can comprehensively evaluate OSA patients to provide more evidence for the primary prevention of coronary heart disease and treatment response assessment.

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Section: Discussionmentioning

confidence: 99%

Endothelial Function and Arterial Stiffness Should Be Measured to Comprehensively Assess Obstructive Sleep Apnea in Clinical Practice

Luo

Wang

Guo

et al. 2021

Front. Cardiovasc. Med.

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“…The results of the present study demonstrated a significantly lower number of positive Nissl stained neurons in the REMsd group compared to other groups. Sleep deprivation is one of the factors that can lead to neurodegenerative changes in the brain (Li et al, 2020). Thalamus is part of the brain that is involved in sleep and wake regulation as well as modulation of pain .…”

Section: Discussionmentioning

confidence: 99%

“…Due to close associations of thalamic neurons with the hypothalamus and brainstem, sleep disturbance may contribute to the alteration of pain perception (Gent et al, 2018). Sleep deprivation may alter level of neurotrophic factors that have an important role in neuron growth, synaptic formation and maturation and neuronal survival (Li et al, 2020). These factors may contribute to neuronal damage and decreased number of Nissl stained neurons in the thalamus.…”

Section: Discussionmentioning

confidence: 99%

“…Although Tualang honey was not administered during the REM sleep deprivation procedure, the honey given prior to the sleep deprivation may have protective effects on the thalamus by modifying certain gene expressions that may reduce oxidative stress. A recent report has shown that candidate plasticity-related gene 15 (cpg15), a neurotrophic gene, protected the brain from oxidative stress (Li et al, 2020) following sleep deprivation. If Tualang honey has positive effects on the gene, the gene may contribute to reduce oxidative stress and protect the neurons in the thalamus.…”

Section: Discussionmentioning

confidence: 99%

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Tualang Honey Modulated Nociceptive Responses in the Thalamus of Rem Sleep Deprivation Rat Model

SHAFIE

Aziz

Noordin

et al. 2021

MABJ

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Sleep deprivation has been shown to alter pain responses in humans and animals. The present study investigated whether the administration of Tualang honey in the rapid eye movement (REM) sleep deprivation rat model would modulate nociceptive responses with associated changes in the thalamus. Forty-eight Sprague Dawley male rats were randomised into four groups (n=12 for each group): control group (FMC), REM sleep deprivation (REMsd), REM sleep deprivation pretreated with Tualang Honey for 1 month (REMsdH) and tank control (TC). Following sleep deprivation for 72 hours, a formalin test was conducted and pain behaviour was recorded and analysed. The rats were sacrificed, and the brains were removed for histological examination and assessment of N-methyl-D-aspartate receptor (NMDA R2) level in the thalamus. REMsdH group showed a significantly lower level of pain behaviour score and NMDA R2 compared to the REMsd group (p<0.05). In addition, REMsdH also demonstrated a significantly higher number of Nissl stained neurons in comparison with the REMsd group (p<0.05). Furthermore, dark neurons, suggestive of neuronal damage, were observed in the REMsd group. In conclusion, administration of Tualang honey before REM sleep deprivation modulated nociceptive responses and prevent changes in thalamic neurons and NMDA R2 level.

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“…Dorsal hippocampus especially contributes to spatial information and other cognitive functions (Strange et al, 2014). Both isoflurane exposure and SD have been well-documented to cause pathological changes in the hippocampus at cellular and molecular levels, including changing the expression of inflammatory proteins, signaling molecules, and oxidative stress factors (Yuan et al, 2019;Li et al, 2020;Wen et al, 2020). However, these studies are much limited to hippocampal neurons in vitro.…”

Section: Introductionmentioning

confidence: 99%

Sleep Deprivation Aggravates Cognitive Impairment by the Alteration of Hippocampal Neuronal Activity and the Density of Dendritic Spine in Isoflurane-Exposed Mice

Zhang

Lian

Ding

et al. 2020

Front. Behav. Neurosci.

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Isoflurane contributes to cognitive deficits when used as a general anesthetic, and so does sleep deprivation (SD). Patients usually suffer from insomnia before an operation due to anxiety, fear, and other factors. It remains unclear whether preoperative SD exacerbates cognitive impairment induced by isoflurane. In this study, we observed the effects of pretreated 24-h SD in adult isoflurane-exposed mice on the cognitive behaviors, the Ca2+ signals of dorsal hippocampal CA1 (dCA1) neurons in vivo with fiber photometry, and the density of dendritic spines in hippocampal neurons. Our results showed that in cognitive behavior tasks, short-term memory damages were more severe with SD followed by isoflurane exposure than that with SD or isoflurane exposure separately, and interestingly, severe long-term memory deficits were induced only by SD followed by isoflurane exposure. Only the treatment of SD followed by isoflurane exposure could reversibly decrease the amplitude of Ca2+ signals when mice were freely moving and increase the duration of Ca2+ signals during the long-term memory behavior test. The density of dendritic spines with both SD and isoflurane exposure was lower than that with SD alone. This study suggests that SD should be avoided preoperatively in patients undergoing elective surgery under isoflurane anesthesia.

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Decreased cpg15 augments oxidative stress in sleep deprived mouse brain

Cited by 5 publications

References 37 publications

Endothelial Function and Arterial Stiffness Should Be Measured to Comprehensively Assess Obstructive Sleep Apnea in Clinical Practice

Endothelial Function and Arterial Stiffness Should Be Measured to Comprehensively Assess Obstructive Sleep Apnea in Clinical Practice

Tualang Honey Modulated Nociceptive Responses in the Thalamus of Rem Sleep Deprivation Rat Model

Sleep Deprivation Aggravates Cognitive Impairment by the Alteration of Hippocampal Neuronal Activity and the Density of Dendritic Spine in Isoflurane-Exposed Mice

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