Decreased contralateral breast volume after mastectomy, adjuvant chemotherapy, and anti-estrogen therapy, in particular in breasts with high density

Ishii, Naohiro; Ando, Jun; Harao, Michiko; Takemae, Masaru; Kishi, Kazuo

doi:10.1016/j.bjps.2017.05.013

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…Although chemotherapy is associated with amenorrhea caused by ovarian dysfunction, Ishii et al [ 12 ] reported no significant difference in breast volume between those who did or did not receive chemotherapy [ 21 ]. Likewise, in our study, we found no significant difference in breast volume according to whether the patient underwent chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…At the same time, this can be the most frustrating aspect of reconstruction for surgeons. Late revisions after single-stage breast reconstruction for asymmetry have been reported in 7.6% to 44% of patients [ 12 ]. Contralateral balancing augmentation or fat injection can be an option for asymmetric breasts; however, optimizing the aesthetic results in a single surgical procedure would be ideal.…”

Section: Discussionmentioning

confidence: 99%

“…Meanwhile, in patients who undergo breast reconstruction, hormonal therapy can cause breast volume to change, both by affecting the breast tissue itself and by affecting the fat distribution and body weight of the patient [ 10 , 11 ]. Ishii et al [ 12 ] reported a significant decrease in breast volume in patients who received adjuvant therapy, especially in those with higher breast density. Theirs was the first study to report a breast volume decrease after adjuvant chemotherapy and tamoxifen therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Theirs was the first study to report a breast volume decrease after adjuvant chemotherapy and tamoxifen therapy. However, a limitation of that study is that they used an uncommon method to measure breast volume [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction

et al. 2018

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BackgroundAdjuvant therapy after breast surgery, including tamoxifen or aromatase inhibitors, improves the postoperative outcomes and long-term survival of breast cancer patients. The aim of this study was to determine whether volume changes occurred in the contralateral breast during hormonal or other adjuvant therapies.MethodsThis study reviewed 90 patients who underwent unilateral breast reconstruction between September 2012 and April 2018 using tissue expanders and a permanent implant after the surgical removal of breast cancer. The volume of the contralateral breast was measured using a cast before the first (tissue expander insertion) and second (permanent implant change) stages of surgery. Changes in breast volume were evaluated to determine whether adjuvant therapy such as hormonal therapy, chemotherapy, and radiation therapy influenced the volume of the contralateral breast.ResultsThe group receiving tamoxifen therapy demonstrated a significant decrease in volume compared with the group without tamoxifen (−7.8% vs. 1.0%; P=0.028). The aromatase inhibitor–treated group showed a significant increase in volume compared with those who did not receive therapy (−6.2% vs. 4.5%; P=0.023). There were no significant differences between groups treated with other hormonal therapy, chemotherapy, or radiation therapy. ConclusionsPatients who received tamoxifen therapy showed a significant decrease in volume in the contralateral breast, while no significant change in weight or body mass index was found. Our findings suggest that we should choose smaller implants for premenopausal patients, who have a high likelihood of receiving tamoxifen therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction

et al. 2018

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“…It is known that adjuvant chemotherapy and anti-estrogenic therapy can result in a decreased volume of the contralateral breast following mastectomy for breast cancer treatment [ 13 ]. We calculated the required flap volume as 1.2×the volume of resected tissue from the mastectomy, in order to reflect the volume change of the contralateral breast after adjuvant chemotherapy or postoperative body weight changes.…”

Section: Discussionmentioning

confidence: 99%

A simple calculation for the preoperative estimation of transverse rectus abdominis myocutaneous free flap volume in 2-stage breast reconstruction using a tissue expander

Kono

Ishii

Takayama³

et al. 2018

Arch Plast Surg

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BackgroundFlap volume is an important factor for obtaining satisfactory symmetry in breast reconstruction with a transverse rectus abdominis myocutaneous (TRAM) free flap. We aimed to develop an easy and simple method to estimate flap volume.MethodsWe performed a preoperative estimation of the TRAM flap volume in five patients with breast cancer who underwent 2-stage breast reconstruction following an immediate tissue expander operation after a simple mastectomy. We measured the height and width of each flap zone using a ruler and measured the tissue thickness by ultrasound. The volume of each zone, approximated as a triangular or square prism, was then calculated. The zone volumes were summed to obtain the total calculated volume of the TRAM flap. We then determined the width of zone II, so that the calculated flap volume was equal to the required flap volume (1.2×1.05×the weight of the resected mastectomy tissue). The TRAM flap was transferred vertically so that zone III was located on the upper side, and zone II was trimmed in the sitting position after vascular anastomosis. We compared the estimated flap width of zone II (=X) with the actual flap width of zone II.ResultsX was similar to the actual measured width. Accurate volume replacement with the TRAM flap resulted in good symmetry in all cases.ConclusionsThe volume of a free TRAM flap can be straightforwardly estimated preoperatively using the method presented here, with ultrasound, ruler, and simple calculations, and this technique may help reduced the time required for precise flap tailoring.

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Volume changes in the reconstructed breast over two years after free abdominal tissue transfer: Comparison of unipedicled versus bipedicled flaps

Kim¹,

Oh²,

Jun³

et al. 2023

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Decreased contralateral breast volume after mastectomy, adjuvant chemotherapy, and anti-estrogen therapy, in particular in breasts with high density

Cited by 5 publications

References 18 publications

Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction

Impact of hormonal therapy and other adjuvant therapies on contralateral breast volume change after implant-based breast reconstruction

A simple calculation for the preoperative estimation of transverse rectus abdominis myocutaneous free flap volume in 2-stage breast reconstruction using a tissue expander

Volume changes in the reconstructed breast over two years after free abdominal tissue transfer: Comparison of unipedicled versus bipedicled flaps

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