Decreased cerebrospinal fluid levels of neutral and basic amino acids in patients with Parkinson's disease

Molina, José Antonio; Jiménez‐Jiménez, Félix Javier; Gómez, Pilar; Vargas, Carmela; Navarro, J. A.; Ortı́-Pareja, M; Gasalla, Teresa; Benito‐León, Julián; Bermejo, F; Arenas, Joaquı́n

doi:10.1016/s0022-510x(97)00069-5

Cited by 92 publications

(30 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In agreement with a previous report (Ö hman and Forsgren 2015), the metabolite mannose, involved in glucose metabolism (Sharma et al 2014), also has a decreased concentration in the CSF of PD patients. Alanine, dimethylamine and glucose all showed an increased concentration, contrary to several studies (Lewitt et al 2013;Mally et al 1997;Molina et al 1997;Ö hman and Forsgren 2015). The BCAA isoleucine, leucine and valine were all found at higher concentrations in the PD patients, similar to the ALS patient group above.…”

Section: Pd Patients Compared To Control Subjectscontrasting

confidence: 55%

“…The BCAA isoleucine, leucine and valine were all found at higher concentrations in the PD patients, similar to the ALS patient group above. Elevated levels of BCAAs in PD patients have previously been observed (Van Sande et al 1971;Lakke and Teelken 1976;Lakke et al 1987), although the opposite has also been reported (Molina et al 1997). As described above, BCAAs are linked in biosynthesis and degradation pathways as well as to neurotransmitter biosynthesis of relevance for the PD pathology.…”

Section: Pd Patients Compared To Control Subjectsmentioning

confidence: 91%

See 1 more Smart Citation

NMR analysis of the CSF and plasma metabolome of rigorously matched amyotrophic lateral sclerosis, Parkinson’s disease and control subjects

Wuolikainen

Trupp

et al. 2016

Metabolomics

View full text Add to dashboard Cite

Introduction Amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) are two severe neurodegenerative disorders for which the disease mechanisms are poorly understood and reliable biomarkers are absent. Objectives To identify metabolite biomarkers for ALS and PD, and to gain insights into which metabolic pathways are involved in disease. Methods Nuclear magnetic resonance (NMR) metabolomics was utilized to characterize the metabolite profiles of cerebrospinal fluid (CSF) and plasma from individuals in three age, gender, and sampling-date matched groups, comprising 22 ALS, 22 PD and 28 control subjects. Results Multivariate analysis of NMR data generated robust discriminatory models for separation of ALS from control subjects. ALS patients showed increased concentrations of several metabolites in both CSF and plasma, these are alanine (CSF fold change = 1.22, p = 0.005), creatine (CSF-fc = 1.17, p = 0.001), glucose (CSFfc = 1.11, p = 0.036), isoleucine (CSF-fc = 1.24, p = 0.002), and valine (CSF-fc = 1.17, p = 0.014). Additional metabolites in CSF (creatinine, dimethylamine and lactic acid) and plasma (acetic acid, glutamic acid, histidine, leucine, pyruvate and tyrosine) were also important for this discrimination. Similarly, panels of CSFmetabolites that discriminate PD from ALS and control subjects were identified. Conclusions The results for the ALS patients suggest an affected creatine/creatinine pathway and an altered branched chain amino acid (BCAA) metabolism, and suggest links to glucose and energy metabolism. Putative metabolic markers specific for ALS (e.g. creatinine and lactic acid) and PD (e.g. 3-hydroxyisovaleric acid and mannose) were identified, while several (e.g. creatine and BCAAs) were shared between ALS and PD, suggesting some overlap in metabolic alterations in these disorders. Keywords Amyotrophic lateral sclerosis (ALS) Á Parkinson's disease (PD) Á NMR metabolomics Á Biomarker Á Cerebrospinal fluid (CSF) Á Plasma Abbreviations ALS Amyotrophic lateral sclerosis PD Parkinson's disease NMR Nuclear magnetic resonance MS Mass spectrometry EDTA Ethylenediaminetetraacetic acid CSF Cerebrospinal fluid CPMG Carr-Purcell-Meiboom-Gill PCA Principal component analysis OPLS Orthogonal projection to latent structures DA Discriminant analysis EP Effect projection CV-ANOVA Analysis of variance testing of crossvalidated predictive residuals CNS Central nervous system BCAA Branched chain amino acids Electronic supplementary material The online version of this article (

show abstract

Section: Pd Patients Compared To Control Subjectscontrasting

confidence: 55%

Section: Pd Patients Compared To Control Subjectsmentioning

confidence: 91%

NMR analysis of the CSF and plasma metabolome of rigorously matched amyotrophic lateral sclerosis, Parkinson’s disease and control subjects

Wuolikainen

Trupp

et al. 2016

Metabolomics

View full text Add to dashboard Cite

show abstract

Section: Neurotransmitters Neuromodulators and Related Substancesmentioning

confidence: 99%

“…CSF levels of neutral and basic amino acids have been reported to be both increased (Van Sande et al, 1971; Lakke and Teelken, 1976; Lakke et al, 1987), and decreased (Molina et al, 1997a). Two groups reported decreased (Molina et al, 1997a; Engelborghs et al, 2003) and another increased CSF levels of taurine (Lakke and Teelken, 1976; Araki et al, 1986; Lakke et al, 1987). Ornithine, citruline, and arginine (implicated in the urea cycle, and the two latter in the synthesis of nitric oxide) have been found to be increased (Van Sande et al, 1971; Lakke and Teelken, 1976; Lakke et al, 1987), normal (Kuiper et al, 2000), or decreased (Molina et al, 1997a).…”

Section: Neurotransmitters Neuromodulators and Related Substancesmentioning

confidence: 99%

“…Two groups reported decreased (Molina et al, 1997a; Engelborghs et al, 2003) and another increased CSF levels of taurine (Lakke and Teelken, 1976; Araki et al, 1986; Lakke et al, 1987). Ornithine, citruline, and arginine (implicated in the urea cycle, and the two latter in the synthesis of nitric oxide) have been found to be increased (Van Sande et al, 1971; Lakke and Teelken, 1976; Lakke et al, 1987), normal (Kuiper et al, 2000), or decreased (Molina et al, 1997a). Another group described increased CSF levels of total homocysteine but normal ones of free homocysteine in PD patients (Isobe et al, 2005), with an additional increase after treatment with levodopa, while total methionine levels decreased after this therapy (Isobe et al, 2010a).…”

Section: Neurotransmitters Neuromodulators and Related Substancesmentioning

confidence: 99%

See 1 more Smart Citation

Cerebrospinal fluid biochemical studies in patients with Parkinson's disease: toward a potential search for biomarkers for this disease

Jiménez‐Jiménez¹,

Alonso‐Navarro

García‐Martín

et al. 2014

Front. Cell. Neurosci.

View full text Add to dashboard Cite

The blood-brain barrier supplies brain tissues with nutrients and filters certain compounds from the brain back to the bloodstream. In several neurodegenerative diseases, including Parkinson's disease (PD), there are disruptions of the blood-brain barrier. Cerebrospinal fluid (CSF) has been widely investigated in PD and in other parkinsonian syndromes with the aim of establishing useful biomarkers for an accurate differential diagnosis among these syndromes. This review article summarizes the studies reported on CSF levels of many potential biomarkers of PD. The most consistent findings are: (a) the possible role of CSF urate on the progression of the disease; (b) the possible relations of CSF total tau and phosphotau protein with the progression of PD and with the preservation of cognitive function in PD patients; (c) the possible value of CSF beta-amyloid 1-42 as a useful marker of further cognitive decline in PD patients, and (d) the potential usefulness of CSF neurofilament (NFL) protein levels in the differential diagnosis between PD and other parkinsonian syndromes. Future multicentric, longitudinal, prospective studies with long-term follow-up and neuropathological confirmation would be useful in establishing appropriate biomarkers for PD.

show abstract

Renewable Surface Carbon‐composite Electrode Bulk Modified with GQD‐RuCl₃ Nano‐composite for High Sensitive Detection of l‐tyrosine

Habibi

Heidari

2016

Electroanalysis

View full text Add to dashboard Cite

1IntroductionTy rosine or 4-hydroxyphenylalanine is av ital constituent of proteins and play important roles in many biochemical processes [1,2].Itisindispensable for humanst oestablish and maintain ap ositive nitrogen balance [2].T yrosine is one of the most important precursors of dopamine,c atecholamine,m elanin, lyothyronine and epinephrine [3].I t has been reported that the unusual concentration levels of tyrosinec ause some humand iseases like tyrosenemia [4],parkinson [5],and psychological ones [6] so the measuring of tyrosine with ar eliable methodi sv ery important from biological and pharmacological stand points.C urrently,d ifferent analytical methodologies have been proposed for tyrosine determination includingh igh performance liquid chromatography [7,8],g as chromatography [9, 10],i on exchange chromatography [11],f luorimetry [12],s pectrophotometry [13],c hemiluminescence [14], and capillary electrophoresis [15] techniques.H owever, these methods are time consuming and expensive.O nt he other hand, electrochemical techniques have somea dvantages such as rapid response,l ow cost and high sensitivity that makes them suitable for routine analysis of electroactive compounds like amino acids [16-18].V arious electrode modifiers like imprinted electrochemical sensor based on gold nanoparticles decorated graphene oxide [19] cobalt hydroxide [20],c opper oxide [21] and Fedoped hydroxyapatite nano-particles [22] have been suggested for l-tyrosine determination.Graphene,atwo dimensional carbon sheet, has attracted considerable attention for use in many fieldss uch as energy storage and sensors due to its large surface area and high electricalc onductivity [23,24].G raphenea nd graphene oxides have been widely used in preparation of the modified electrode for oxidation of methanol [25][26][27] and detection of DNAh ybridization [28],c itrinin [29], curcumin [30],q uercetin and morin [31, 32],g lucose [33], impedimetric [34],o chratoxin A[ 35],a nd Cu(II) and Cd(II) [36].R ecently,g raphene quantum dots (GQDs), as an ew zero dimensional material, has emergeda s apromising material for the development of electrochemical sensors.T ing et al. used GQD-Aue lectrocatalyst for high sensitive detectiono fh eavy metal ions [37].Z hao et al. proposed GQDm odified graphite electrode for sensing of ssDNAm olecules[ 38].In the presenti nvestigation, we describe as imple methodb asedo ns ol-gel technology to prepare renewable surface carbon-composite electrode (CCE) bulk modified with GQD-RuCl 3 nano-compositef or electroanalytical detectiono fl-tyrosine.T he constructed biosensor showed high stabilitya nd good electrocatalytic activity for the detectiono fl-tyrosine.Abstract:T he ability to analytically detect l-tyrosine is ac linicaln ecessity not only for the diagnosis of some diseases such as tyrosinemia, but also for the studyo nvarious tyrosine-associated disorders.I nh ere,g rapheneq uantum dot (GQD) was synthesized by carbonization of citric acid and used to prepareG QD-RuCl 3 nano-composite.G QD and GQD-RuCl 3 we...

show abstract

Decreased cerebrospinal fluid levels of neutral and basic amino acids in patients with Parkinson's disease

Cited by 92 publications

References 13 publications

NMR analysis of the CSF and plasma metabolome of rigorously matched amyotrophic lateral sclerosis, Parkinson’s disease and control subjects

NMR analysis of the CSF and plasma metabolome of rigorously matched amyotrophic lateral sclerosis, Parkinson’s disease and control subjects

Cerebrospinal fluid biochemical studies in patients with Parkinson's disease: toward a potential search for biomarkers for this disease

Renewable Surface Carbon‐composite Electrode Bulk Modified with GQD‐RuCl₃ Nano‐composite for High Sensitive Detection of l‐tyrosine

Contact Info

Product

Resources

About

Decreased cerebrospinal fluid levels of neutral and basic amino acids in patients with Parkinson's disease

Cited by 92 publications

References 13 publications

NMR analysis of the CSF and plasma metabolome of rigorously matched amyotrophic lateral sclerosis, Parkinson’s disease and control subjects

NMR analysis of the CSF and plasma metabolome of rigorously matched amyotrophic lateral sclerosis, Parkinson’s disease and control subjects

Cerebrospinal fluid biochemical studies in patients with Parkinson's disease: toward a potential search for biomarkers for this disease

Renewable Surface Carbon‐composite Electrode Bulk Modified with GQD‐RuCl3 Nano‐composite for High Sensitive Detection of l‐tyrosine

Contact Info

Product

Resources

About

Renewable Surface Carbon‐composite Electrode Bulk Modified with GQD‐RuCl₃ Nano‐composite for High Sensitive Detection of l‐tyrosine