Decreased central corneal thickness in ankylosing spondylitis

Ortak, Hüseyin; Inanir, Ahmet; Demir, Selim; Uysal, Alper; Sahin, Şevki; Sağcan, Mustafa; Önder, Yalçın; Alim, Sait; Demir, Ayşe Kevser

doi:10.1007/s10792-013-9827-2

Cited by 10 publications

(6 citation statements)

References 29 publications

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“…Ortak et al also found thinner corneas and lower dry eye tests in a group of 68 AS patients. Consequently, they suggested careful attention in surgical interventions such as photorefractive keratectomy and laser in situ keratomileuses in AS patients 39 . Despite the dysfunctional dry eye tests found in these studies, the authors did not determine the DED severity level.…”

Section: Discussionmentioning

confidence: 99%

Improvement of conjunctival cytological grade and tear production in Ankylosing Spondylitis patients under TNF inhibitors: a long-term follow-up

Usuba

Saad

Aikawa

et al. 2020

Sci Rep

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Dry eye disease can compromise the patient's quality of life. few studies assessed the ocular surface (oS) in Ankylosing Spondylitis (AS) patients. this study aimed to evaluate the clinical and cytological findings of the OS in patients with AS, classify dry eye disease (DED) severity grade and conjunctival impression cytology (IC), and the effects of TNF inhibitors (TNFi) in a one-year follow-up. A baseline (BL) evaluation included 36 AS patients and 39 healthy controls. They fulfilled the Ocular Surface Index Disease questionnaire and underwent the Schirmer i test, break-up time, vital staining, and conjunctival ic. A DeD severity grade, as well as ic rating, was applied. fourteen of these patients received tnfi and analysis of ocular and systemic AS disease parameters occurred at BL and three months (3 M), and 12 months (12 M) after treatment. The AS patients presented a higher frequency of DED (p = 0.01), a worse score of severity (p = 0.001), and a higher frequency of altered IC (p = 0.007) when compared to controls. The 14 patients under TNFi presented an improvement in all the clinical disease activity parameters throughout the one-year treatment (p < 0.05) even as a concomitant increase in the Schirmer test (p = 0.04), and a significant amelioration in the altered IC to a normal IC (p = 0.006). DED is a frequent and under-diagnosed ocular disease in AS patients. the long-term parallel improvement of disease activity and oS parameters in AS patients receiving tnfi suggests that the oS can be an additional target of systemic inflammation in AS.

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Section: Discussionmentioning

confidence: 99%

Improvement of conjunctival cytological grade and tear production in Ankylosing Spondylitis patients under TNF inhibitors: a long-term follow-up

Usuba

Saad

Aikawa

et al. 2020

Sci Rep

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“…Only a few studies have investigated the corneal biomechanical properties, such as CCT and ORA parameters in CVD. [7][8][9][10][11][12] Prata et al have demonstrated abnormal corneal biomechanics in patients with rheumatoid arthritis (lower corneal hysteresis and IOP values than healthy controls). 8 Similarly, Yazici et al 9 have reported that patients with systemic lupus erythematosus present with lower corneal hysteresis, lower corneal resistance factor (CRF), and Goldmann-related IOP values compared with age-matched controls.…”

Section: Corneal Biomechanical Properties In Systemic Inflammatory DImentioning

confidence: 99%

“…7 Recently, a study also found a significant lower CCT in patients with another CVD-ankylosing spondylitis -when compared with aged-matched controls. 12 CCT in scleroderma has been subject to debate because of conflicting reports. Although a study conducted by Serup et al 31 has found significantly increased CCT in scleroderma, recent studies have failed to confirm this finding.…”

Section: Corneal Biomechanical Properties In Systemic Inflammatory DImentioning

confidence: 99%

“…3 The overall understanding of corneal manifestations derived from immunologic and rheumatologic inflammatory disorders has continued to expand over the past few years, with corneal characteristics being described using histological diagnostic techniques, corneal topographic maps, in vivo confocal microscopy, ocular response analyzer (ORA) parameters, and central corneal thickness (CCT) measurements. [4][5][6][7][8][9][10][11][12] The purpose of this review is to summarize corneal abnormalities and characteristics in the setting of systemic inflammatory diseases.…”

Section: Introductionmentioning

confidence: 99%

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Corneal Involvement in Systemic Inflammatory Diseases

Gomes

Santhiago

Jorge³

et al. 2015

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Corneal involvement in patients with systemic inflammatory disorders may be sight threatening, and it may be associated with a life-threatening disease. Significant systemic inflammatory diseases in this context are autoimmune connective tissue diseases, systemic autoimmune dermatological disorders, and autoimmune diseases of the lacrimal system. Keratoconjunctivitis sicca is usually the most common ocular finding in these patients. Peripheral ulcerative keratitis is a rare condition usually associated with increased ocular morbidity and also mortality, as it might act as an indicator of a more widespread vasculitis. Corneal biomechanical properties may also be altered in connective tissue diseases. Although recent studies suggest that the risk for corneal complications after ocular surgery in patients with quiescent autoimmune disease is minimal, caution is still recommended, as the knowledge about the corneal wound-healing process and the corneal biomechanical properties in these patients is not yet fully understood. This article reviews corneal abnormalities and characteristics in the setting of systemic inflammatory diseases.

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“…27 In their study on patients with ankylosing spondylitis (AS), Ortak et al reported thinning in CT in patients with AS compared with the control group. 28 Czompa et al compared the CT of a total of 66 inflammatory bowel disease patients (30 patients with Crohn's disease and 36 with ulcerative colitis) with the control group and found a significant reduction in CT in patients with inflammatory bowel diseases. 29 Gökmen et al found that the CT was thinner in patients with rheumatoid arthritis (RA), but this difference was not statistically significant.…”

mentioning

confidence: 99%

Evaluation of the corneal endothelium by specular microscopy in patients with chronic obstructive pulmonary disease

Songur

İntepe

Bayhan

et al. 2021

Clinical Respiratory J

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The corneal endothelium consists of a single nonregenerative layer of predominantly hexagonal cells. Corneal endothelial cells keep the stroma dry by actively removing water, which is a vital function in maintaining normal corneal transparency. 1 Corneal tissue is avascular. Normal corneal metabolism is dependent on a critical oxygen level, below which a number of acute metabolic events including an increase in stromal lactate and corneal hydration and a decrease in intercellular pH levels occur. 2 The oxygen required for the basic metabolism of the cornea is obtained from the atmosphere, primarily through tears and diffusion on the anterior surface of the cornea and through the aqueous humor in the anterior chamber. 3 Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by an abnormal inflammatory response of the respiratory tract to some particles and gases. 4 This inflammation results in progressive and continuous air flow restriction, leading to alveolar hypoxia and consequently hypoxemia. 5 The most common systemic effects of COPD are weight loss and malnutrition; however, diabetes, sleep-disordered breathing, upper and lower respiratory tract infections, myocardial infarction, depression, osteoporosis, anemia, and lung cancer are also common in COPD. 6 Chronic hypoxia, chronic inflammation, and oxidative stress that occur due to gas exchange disorders in COPD affect peripheral tissues such as the eye. 7 A diagnosis of COPD is made when the ratio of forced expiratory volume in the first

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Decreased central corneal thickness in ankylosing spondylitis

Cited by 10 publications

References 29 publications

Improvement of conjunctival cytological grade and tear production in Ankylosing Spondylitis patients under TNF inhibitors: a long-term follow-up

Improvement of conjunctival cytological grade and tear production in Ankylosing Spondylitis patients under TNF inhibitors: a long-term follow-up

Corneal Involvement in Systemic Inflammatory Diseases

Evaluation of the corneal endothelium by specular microscopy in patients with chronic obstructive pulmonary disease

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