Corneal Involvement in Systemic Inflammatory Diseases

Gomes, Beatriz A.F.; Santhiago, Marcony R.; Jorge, Priscilla Almeida; Kara‐José, Newton; Moraes, Haroldo Vieira de; Kara-Júnior, Newton

doi:10.1097/icl.0000000000000141

Cited by 18 publications

(15 citation statements)

References 47 publications

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“…Corneal stroma, which comprised 90% of total corneal thickness, was the major part that contributed to the corneal biomechanical properties [16]. Various conditions associated with corneal stromal inflammation such as keratoconus, Sjogren syndrome, herpes stromal keratitis have shown to be associated with more compliant corneas [32][33][34][35][36]. Despite that the immunopathogenesis of DED has not yet been fully understood, numerous studies have concluded that ocular surface inflammation displayed a critical role [37][38][39].…”

Section: Plos Onementioning

confidence: 99%

Alteration of corneal biomechanical properties in patients with dry eye disease

et al. 2021

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Purpose To evaluate the association between symptoms and signs of dry eye diseases (DED) with corneal biomechanical parameters. Methods This cross-sectional study enrolled 81 participants without history of ocular hypertension, glaucoma, keratoconus, corneal edema, contact lens use, diabetes, and ocular surgery. All participants were evaluated for symptoms and signs of DED using OSDI questionnaire, tear film break-up time (TBUT), conjunctival and corneal staining (NEI grading) and Schirmer test. Corneal biomechanical parameters were obtained using Corvis ST. Mixed-effects linear regression analysis was used to determine the association between symptoms and signs of DED with corneal biomechanical parameters. Difference in corneal biomechanical parameter between participants with low (Schirmer value ≤10 mm; LT group) and normal (Schirmer value >10mm; NT group) tear production was analyzed using ANCOVA test. Results The median OSDI scores, TBUT, conjunctival and corneal staining scores as well as Schirmer test were 13±16.5 (range; 0–77), 5.3±4.2 seconds (range; 1.3–11), 0±1 (range; 0–4), 0±2 (ranges; 0–9) and 16±14 mm (range; 0–45) respectively. Regression analysis adjusted with participants’ refraction, intraocular pressure, and central corneal thickness showed that OSDI had a negative association with highest concavity radius (P = 0.02). The association between DED signs and corneal biomechanical parameters were found between conjunctival staining scores with second applanation velocity (A2V, P = 0.04), corneal staining scores with second applanation length (A2L, P = 0.01), Schirmer test with first applanation time (A1T, P = 0.04) and first applanation velocity (P = 0.01). In subgroup analysis, there was no difference in corneal biomechanical parameters between participants with low and normal tear production (P>0.05). The associations were found between OSDI with time to highest concavity (P<0.01) and highest displacement of corneal apex (HC-DA, P = 0.04), conjunctival staining scores with A2L (P = 0.01) and A2V (P<0.01) in LT group, and Schirmer test with A1T (P = 0.02) and HC-DA (P = 0.03), corneal staining scores with A2L (P<0.01) in NT group. Conclusions According to in vivo observation with Corvis ST, patients with DED showed more compliant corneas. The increase in dry eye severity was associated with the worsening of corneal biomechanics in both patients with low and normal tear production.

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Section: Plos Onementioning

confidence: 99%

Alteration of corneal biomechanical properties in patients with dry eye disease

et al. 2021

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“…The problems that remain to be solved are questions for antigen recognition mechanisms involved in triggering the systemic inflammatory conditions induced by pollen exposure in patients with immune-mediated SIDs. A previous study reported that corneal involvement in patients with systemic inflammatory disorders may be sight-threatening and associated with a life-threatening disease [17].…”

Section: The Limits Of Our Study and Other Issuesmentioning

confidence: 99%

A retrospective study on the relationship between annual airborne pollen levels during four decades of 1975–2014 and annual occurrence of ulcerative colitis, Crohn's disease, primary biliary cirrhosis, fulminant hepatitis, severe acute pancreatitis, interstitial pneumonia, amyloidosis, based on the national registry database of specific intractable diseases in Japan

Awaya¹,

Kuroiwa²

2019

Arch Epid Pub Health

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Background: Systemic vasculitis such as Kawasaki Disease (KD) and collagen diseases have been suggested to be related to pollen exposure (PE).Objective: To elucidate effects of PE on outbreaks of gastrointestinal diseases including inflammatory bowel diseases(IBDs) and associated diseases. Methods:We analyzed national database on annual occurrence of ulcerative colitis(UC), Crohn's disease(CD), as well as primary biliary cirrhosis(PBC), fulminant hepatitis(FH), severe acute pancreatitis(SAP), interstitial pneumonia(IP), amyloidosis(AMY), idiopathic thrombocytopenic purpura and aplastic anemia.

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“…Conjunctivitis, episcleritis, scleritis, and anterior uveitis are by far the most prevalent EIMs surveyed in the literature, while corneal changes are unfairly underrepresented among them although the cornea is a notably predisposed site to immune-related disorders due to its large content of collagen. 5 To the best of our knowledge, no investigation of corneal and other anterior segment parameters has been reported in patients with IBD thus far. For this reason, the primary aim of our study was to evaluate various anterior segment parameters in IBD patients, while the secondary aim was to appraise associations between anterior segment values and other clinical variables with special interest in dry eye disease (DED).…”

Section: Introductionmentioning

confidence: 99%

Corneal Manifestations of Inflammatory Bowel Disease

Czompa

Barta

Ziad

et al. 2019

Seminars in Ophthalmology

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Purpose: To evaluate detailed corneal parameters of inflammatory bowel disease (IBD) patients, including Crohn's disease (CD) and ulcerative colitis (UC) patients, and to assess associations between anterior segment values and other clinical variables. Methods: This prospective cross-sectional case-control study at a tertiary referral center included 30 CD patients, 36 UC patients and 80 age-and gender-matched controls with no ocular symptoms or ocular surface disorders. All study participants underwent a comprehensive ophthalmological evaluation with special interest in dry eye disease (DED). Corneal parameters were evaluated by Pentacam. Results: The mean age of CD patients, UC patients, and controls was 45.80 ± 11.55 years, 52.00 ± 16.05, and 50.68 ± 14.62, respectively. The average disease duration was 12.72 ± 5.83 years for CD patients and 15.94 ± 10.09 years for UC patients. All pachymetric (center, apex and thinnest) and corneal volume (CV) measurements were significantly decreased, while anterior chamber angle width (ACA) values were significantly increased on both sides in all IBD patients compared to those in controls (p < .05). In addition, several anterior segment parameters were altered unilaterally in CD or UC patients. Negative correlations were found between corneal parameters and Schirmer I test values. Conclusions: Our investigations suggest that IBD patients have thinner corneas compared to that of controls. The coexistence of reduced tear quantity seems to have an additional impact on the thinning of the cornea in IBD patients. Early recognition of corneal impairments, a possible extraintestinal manifestation of IBD, should be included in the disease checkup to reduce vision-threatening developments.

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Corneal Involvement in Systemic Inflammatory Diseases

Cited by 18 publications

References 47 publications

Alteration of corneal biomechanical properties in patients with dry eye disease

Alteration of corneal biomechanical properties in patients with dry eye disease

Corneal Manifestations of Inflammatory Bowel Disease

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