Decreased blood flow at neuroretinal rim of optic nerve head corresponds with visual field deficit in eyes with normal tension glaucoma

Sato, Enrique Adan; Ohtake, Yuichiro; Shinoda, Kei; Mashima, Yukihiko; Kimura, Ikuo

doi:10.1007/s00417-005-0177-2

Cited by 50 publications

(30 citation statements)

References 31 publications

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“…Several clinical investigators [23,24,25] have revealed that both optic disk rim blood flow and peripapillary retinal blood flow are significantly lower in patients with OAG as compared with age-matched controls, and thus optic disk rim blood flow is significantly correlated with deterioration of existing visual field defects. Hafez et al [26] evaluated and compared optic disk rim blood flow in patients with OAG and those with ocular hypertension (OH) and found that OAG patients had significantly lower values than OH patients.…”

Section: Discussionmentioning

confidence: 99%

Two-Year Randomized, Placebo-Controlled Study of Black Currant Anthocyanins on Visual Field in Glaucoma

Ohguro

Katai

et al. 2012

Ophthalmologica

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Aim: To examine the influence of the black currant anthocyanins (BCACs) on the disease progression of open-angle glaucoma (OAG), a randomized, placebo-controlled, double-masked trial was made in 38 patients with OAG treated by antiglaucoma drops. Methods: BCACs (50 mg/day, n = 19) or their placebos (n = 19) were orally administered once daily for a 24-month period. Systemic blood pressure, pulse rates, intraocular pressure (IOP), ocular blood circulation by laser-speckle flowgraphy, and Humphrey visual field mean deviation (MD) were measured during the 24-month period. Results: As a main outcome measurement, we evaluated the difference between the groups in MD deterioration in the eye with a better MD from the trial’s baseline through 24 months. A statistically significant difference was observed between the treatment groups in mean change from baseline in MD 24 months after therapy (p = 0.039, unpaired t test). Upon administration of BCACs, the ocular blood flows during the 24-month observational period increased in comparison with placebo-treated patients. However, no significant changes were observed in systemic and ocular conditions including IOP during the 24-month period. Conclusions: Our results suggest that oral administration of BCACs may be a safe and promising supplement for patients with OAG in addition to antiglaucoma medication.

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Section: Discussionmentioning

confidence: 99%

Two-Year Randomized, Placebo-Controlled Study of Black Currant Anthocyanins on Visual Field in Glaucoma

Ohguro

Katai

et al. 2012

Ophthalmologica

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“…3,4 This is because, in addition to the elevated IOPs, ocular blood circulation, oxidative stress, and other mechanisms are also believed to be involved in the GON etiology. Regarding ocular blood circulation, evidence from numerous reports indicating that insufficient retinal and optic disc blood supply are involved in the GON etiology includes the following: (1) Disc hemorrhages frequently exist in patients with open-angle glaucoma (OAG) [6][7][8] ; (2) retinal vascular diseases, such as retinal vein occlusion, are frequently associated with OAG patients with OAG 10,11 ; (4) there are abnormal levels of the concentration of plasma endothelin-1 (ET-1) in patients with OAG as compared with healthy control subjects [12][13][14][15] ; (5) platelet aggregation ability is remarkably increased in patients with OAG compared with that in normal subjects. 16 As for oxidative stress, reactive oxygen species (ROS) are produced as a consequence of normal aerobic metabolism.…”

Section: Introductionmentioning

confidence: 99%

Black Currant Anthocyanins Normalized Abnormal Levels of Serum Concentrations of Endothelin-1 in Patients with Glaucoma

Yoshida

Ohguro

2013

Journal of Ocular Pharmacology and Therapeutics

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Purpose: Our recent study, which involved a randomized, placebo-controlled, double-masked 24-month trial (Ophthalmologica 2012;228:26-35), revealed that oral administration of black currant anthocyanins (BCACs) slowed down the visual field deterioration and elevation of ocular blood flow of open-angle glaucoma (OAG). To elucidate the underlying mechanisms of these BCAC-induced effects, as possible factors affecting glaucomatous optic neuropathy, changes of serum endothelin-1 (ET-1), nitric oxide (NO), and antioxidative activities were examined in the present study. Methods: From among patients with OAG who participated in the randomized, placebo-controlled, doublemasked trial, serum specimens were obtained from BCAC-treated (n = 19) or placebo-treated (n = 19) patients at baseline and every 6 months. Healthy volunteers (n = 20) with age and gender matching the patients were used as a control. Serum ET-1 concentration, [NO 2 -] and [NO 2 -+ NO 3 -] levels, advanced oxidation protein products (AOPP), and antioxidant activities were measured by using commercially available kits. Results: At the trial baseline, serum ET-1 concentrations were significantly lower in patients with OAG (BCACs, 3.18 -1.06 pg/mL; placebo, 3.44 -0.84 pg/mL) than those in healthy volunteers (4.38 -1.03 pg/mL) (one-way analysis of variance and a Tukey's multiple comparison post hoc test, P < 0.05). Upon administration of BCACs, serum ET-1 concentrations increased to the levels of those in healthy volunteers during the 24-month period. In contrast, those of placebo-treated patients remained at lower levels (3.82 -1.14 pg/mL). While [NO 2 -] and [NO 2 -+ NO 3 -] levels, AOPP, and antioxidative activities of patients from both the BCACs and placebo groups showed comparable levels to those of healthy subjects at baseline, no significant changes were observed during the observational period in either the BCAC or placebo groups. Conclusions: Among the possible beneficial effects of BCACs toward visual field progression in patients with OAG, our present results suggest that BCACs caused normalization of serum ET-1 levels, and this may modulate ET-1-dependent regulation of the ocular blood hemodynamics.

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“…These losses have been related to larger cup-to-disc ratios, 166 and are spatially associated with optic nerve head structural damage and visual field defects. 167,168 Specifically, Logan et al 167 found decreased capillary flow in areas of the retina associated with abnormal optic disc segments. In contrast, normal optic disc segments from these same glaucoma patients were not associated with compromised retinal flow.…”

Section: Relationship Between Ocular Blood Flowvisual Function and mentioning

confidence: 97%

“…These losses have been related to larger cup-to-disc ratios, 166 and are spatially associated with optic nerve head structural damage and visual field defects. 167,168 Combined with the previous technologies' data on retinal blood flow, HRF measurements point to a reduction in retinal blood supply in ophthalmic disease such as glaucomatous optic neuropathy.…”

Section: Confocal Scanning Laser Doppler Flowmetrymentioning

confidence: 99%

Glaucoma Risk Factors: Ocular Blood Flow

et al. 2010

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Decreased blood flow at neuroretinal rim of optic nerve head corresponds with visual field deficit in eyes with normal tension glaucoma

Abstract: The blood flow in the neuroretinal rim was found to correspond to the regional visual field defect in eyes with NTG. Reductions in flow were associated with reductions in function.

Cited by 50 publications

References 31 publications

Two-Year Randomized, Placebo-Controlled Study of Black Currant Anthocyanins on Visual Field in Glaucoma

Two-Year Randomized, Placebo-Controlled Study of Black Currant Anthocyanins on Visual Field in Glaucoma

Black Currant Anthocyanins Normalized Abnormal Levels of Serum Concentrations of Endothelin-1 in Patients with Glaucoma

Glaucoma Risk Factors: Ocular Blood Flow

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