2009
DOI: 10.1523/jneurosci.6039-08.2009
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Decreased BDNF Levels Are a Major Contributor to the Embryonic Phenotype of Huntingtin Knockdown Zebrafish

Abstract: Huntington's disease (HD) is an autosomal dominant, neurodegenerative condition caused by a CAG trinucleotide repeat expansion that is translated into an abnormally long polyglutamine tract in the protein huntingtin. Genetic and transgenic studies suggest that the mutation causes disease predominantly via gain-of-function mechanisms. However, loss of normal huntingtin function resulting from the polyglutamine expansion might also contribute to the pathogenesis of HD. Here, we have studied the effects of huntin… Show more

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Cited by 77 publications
(63 citation statements)
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References 32 publications
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“…Wnt/␤-catenin signaling is known to play a key role in the regulation of embryogenesis and oncogenesis (85)(86)(87). In zebrafish, activation of the Wnt/␤-catenin pathway facilitates cardiac differentiation before gastrulation but perturbs it at later stages (45).…”
Section: Discussionmentioning
confidence: 99%
“…Wnt/␤-catenin signaling is known to play a key role in the regulation of embryogenesis and oncogenesis (85)(86)(87). In zebrafish, activation of the Wnt/␤-catenin pathway facilitates cardiac differentiation before gastrulation but perturbs it at later stages (45).…”
Section: Discussionmentioning
confidence: 99%
“…In zebrafish embryos/larvae, bdnf is critical in neuronal development, with bdnf knockdown causing severe brain atrophy, with experimental zebrafish larvae lacking most of the neurites [38]. Thus, downregulation of bdnf observed in our study might also contribute to impaired DA neurodevelopment and decreased DA content.…”
Section: Acc E P Ted P R E P R I Ntmentioning
confidence: 56%
“…↓ Food consumption After feeding, bdnf expression increases; knockdown decreases locomotor activity and shows Huntington-like symptoms (zebrafish) [295] Corticotropin releasing hormone (CRH) ↓ Food consumption ICV administration suppresses food consumption and increases anxiety-like behavior and locomotion (goldfish) [206,296] Octadecaneuropeptide (ODN) ↓ Food consumption and ↑ Locomotion ICV administration suppresses food consumption and locomotion (goldfish) [297] Pituitary adenylatecyclase-activating polypeptide (PACAP)…”
Section: Genesmentioning
confidence: 99%