Developing ‘integrative’ zebrafish models of behavioral and metabolic disorders

The failure of anxiolytic therapies in early clinical trials: what needs to be done

“…Thus, the experimental manipulations widely used in animal models, ranging from behavioral to genetic and pharmacological challenges, may be unable to fully recapitulate similar factors in humans [9]. However, despite these limitations, animal models continue to be indispensable for studying the neurobiology of ASD and anxiolytic drug discovery [11,[15][16][17][18][19][20][21]. Several strategies summarized here address the problem of enhancing anxiolytic drug discovery and improving the overall success of their transition from preclinical to early clinical trials.…”

A novel 3D method of locomotor analysis in adult zebrafish: Implications for automated detection of CNS drug-evoked phenotypes

“…Applying a wide spectrum of model organisms to study human brain phenotypes is critical for improving our understanding of the basic pathobiology of neuropsychiatric disorders (Grossman et al, 2010;Neelkantan et al, 2013;Nguyen et al, 2013;Stewart and Fig. 1.…”

Unpredictable Chronic Stress Alters Adenosine Metabolism in Zebrafish Brain

“…UCS changes brain physiology and neural circuits [14] and leads to the development of depressive behaviors [15]. In mammalians, the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system (SNS) have a major role on physiological stress response in the body and constitute the main effector pathways of the stress system, mediating their adaptive functions [3,16] Zebrafish is a helpful model organism to evaluate stress and anxiety [17][18][19][20] and is useful for assessing behavioral and molecular mechanisms of brain disorders [21][22][23], developmental biology, pathophysiology of metabolic diseases, and neurodegeneration [24][25][26][27]. There is a high degree of homology between zebrafish and humans, as the presence of a homologue of the HPA axis, the hypothalamic-pituitary-interrenal axis (HPI).…”