Decreased baroreflex sensitivity in patients with stable coronary artery disease is correlated with the severity of coronary narrowing

Katsube, Yoshiki; Sato, Hideyuki; Naka, Masashi; Kim, Bong Ha; Kinoshita, Naokazu; Koretsune, Yukihiro; Hori, Masatsugu

doi:10.1016/s0002-9149(96)00525-5

Cited by 61 publications

(48 citation statements)

References 24 publications

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“…Cardiovascular conditions such as cardiac arrhythmias, coronary artery disease, and cardiac infarction are accompanied by alterations in baroreflex function (11)(12)(13). It is also well established that the baroreflex is inhibited in chronically elevated blood pressure (14,15).…”

Section: Introductionmentioning

confidence: 99%

Increased Baroreflex Sensitivity and Reduced Cardiovascular Reactivity in Individuals with Chronic Low Blood Pressure

Duschek¹,

Dietel²,

Schandry³

et al. 2008

Hypertens Res

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Section: Introductionmentioning

confidence: 99%

Increased Baroreflex Sensitivity and Reduced Cardiovascular Reactivity in Individuals with Chronic Low Blood Pressure

Duschek¹,

Dietel²,

Schandry³

et al. 2008

Hypertens Res

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“…1 It has been described that arterial baroreflex sensitivity can be profoundly altered in some cardiovascular diseases. 2,3 In hypertension, some investigators, 4 -6 but not all, [7][8][9] observed that baroreflex control of heart rate (HR) and sympathetic nerve activity is significantly reduced. This autonomic dysfunction seems to correlate with an increase in sympathetic outflow and in BP levels.…”

mentioning

confidence: 99%

Exercise Training Restores Baroreflex Sensitivity in Never-Treated Hypertensive Patients

Laterza

Matos²,

Trombetta³

et al. 2007

Hypertension

245

168

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Abstract-The effects of exercise training on baroreflex control of sympathetic nerve activity in human hypertension are unknown. We hypothesized that exercise training would improve baroreflex control of muscle sympathetic nerve activity (MSNA) and heart rate (HR) in patients with hypertension and that exercise training would reduce MSNA and blood pressure (BP) in hypertensive patients. Twenty never-treated hypertensive patients were randomly divided into 2 groups: exercise-trained (nϭ11; age: 46Ϯ2 years) and untrained (nϭ9; age: 42Ϯ2 years) patients. An age-matched normotensive exercise-trained group (nϭ12; age: 42Ϯ2 years) was also studied. Key Words: hypertension Ⅲ baroreflex sensitivity Ⅲ sympathetic nerve activity Ⅲ exercise Ⅲ blood pressure T here is accumulated evidence that arterial baroreflex plays an important role in the regulation of the cardiovascular system. During spontaneous variation of blood pressure (BP), stimulation or deactivation of the arterial baroreceptors located in the carotid sinus and aortic arch causes reflex bradycardia and tachycardia, respectively. At the vascular level, stimulation of the arterial baroreceptors results in sympathetic inhibition and, in consequence, reflex vasodilation. In contrast, the deactivation of the arterial baroreceptors elicits sympathetic-mediated vasoconstriction. 1 All of these responses work in concert to maintain the BP levels in the reference range. 1It has been described that arterial baroreflex sensitivity can be profoundly altered in some cardiovascular diseases. 2,3 In hypertension, some investigators, 4 -6 but not all, 7-9 observed that baroreflex control of heart rate (HR) and sympathetic nerve activity is significantly reduced. This autonomic dysfunction seems to correlate with an increase in sympathetic outflow and in BP levels. 10 On the other hand, previous studies have demonstrated that regular exercise causes significant changes in baroreflex control of HR in experimental hypertension. Exercise training improves baroreflex control of HR during the increase and decrease of BP in spontaneously hypertensive rats. 11,12 Furthermore, these studies indicate that the improvement in baroreflex sensitivity is, in part, mediated by the enhancement of the aortic depressor nerve sensitivity. In humans with hypertension, little information exists regarding the effects of exercise training on the baroreflex sensitivity. One of the few studies showed that exercise training caused a modest improvement in baroreflex bradycardia. 13 Thus, the effects of regular exercise on the baroreflex control of sympathetic nerve activity in humans with hypertension are unknown.It has been consistently shown that exercise training is a powerful nonpharmacological strategy to reduce BP levels in humans with hypertension. 14 -16 However, the mechanisms involved in the BP reduction after exercise training are still a matter of discussion. In the present study, we investigated the

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“…Low HRV is associated with mortality risk in post-myocardial infarction patients [23,24] and also in the general population [25,26]. Also, autonomic neuropathy has been proposed to play a role in the aetiology of cardiovascular disease [27,28,29,30,31] and nephropathy [32,33] in diabetes. So far, the agreement between the autonomic functions tests, their reproducibility and reference values have not been reported in a single study.…”

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confidence: 99%

Measures of cardiovascular autonomic nervous function: agreement, reproducibility, and reference values in middle age and elderly subjects

et al. 2003

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Aims/hypothesis. Currently, three categories of cardiovascular autonomic nervous function measures are used: classic Ewing-test measures, measures of heartrate variability (HRV), and measures of baroreflex sensitivity (BRS). Little is known about the agreement between these measures, and reference and reproducibility values for these measures have not been reported within the same group. Methods. As part of the Hoorn Study, 631 subjects aged 50 to 75 participated in a study of autonomic nervous function. Cardiac cycle duration (RR interval) and continuous finger arterial pressure were measured under three conditions: during spontaneous breathing, during six deep breaths over 1 min, and during an active change in position from lying to standing. From these readings, ten measures of autonomic function were assessed (mean heart rate, three Ewing test measures, five HRV measures and one BRS measure). Results. Regression analysis in a healthy subgroup (n=191) showed sex differences for two of the ten measures and seven measures decreased with age. Therefore, appropriate age-specific and sex-specific reference values were calculated. Reproducibility (n=39) of most measures was moderate, with a reliability coefficient of around 50%. Agreement between the measures of autonomic nervous function varied greatly, between 0% and 87%. The HRV-power ratio measure and the blood pressure changes in the lyingto-standing test showed the lowest agreement with all other measures. Conclusion/Interpretation. This study provides agespecific and sex-specific reference values for a wide range of different autonomic function measures in an elderly population. Agreement among the different measures varied widely and reproducibility was only moderate. [Diabetologia (2003) 46:330-338] Keywords Aging, agreement, baroreflex, diabetes mellitus, heart-rate variability, nervous system, autonomic, reference values, reproducibility.

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Decreased baroreflex sensitivity in patients with stable coronary artery disease is correlated with the severity of coronary narrowing

Cited by 61 publications

References 24 publications

Increased Baroreflex Sensitivity and Reduced Cardiovascular Reactivity in Individuals with Chronic Low Blood Pressure

Increased Baroreflex Sensitivity and Reduced Cardiovascular Reactivity in Individuals with Chronic Low Blood Pressure

Exercise Training Restores Baroreflex Sensitivity in Never-Treated Hypertensive Patients

Measures of cardiovascular autonomic nervous function: agreement, reproducibility, and reference values in middle age and elderly subjects

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