Decrease of Pericytes is Associated With Liver Disease Caused by Ligature-Induced Periodontitis in Rats

Vasconcelos, Daniel Fernando Pereira; Silva, Felipe M. A. da; Pinto, Moara e Silva Conceição; Santana, Lucas Alves da Mota; Souza, Ingrid Grazielle; Souza, Luan Kelves Miranda de; Oliveira, Natássia Cristina Martins; Ventura, Claudio Angelo; Novaes, Pedro Duarte; Barbosa, André Luiz dos Reis; Medeiros, Jand Venes R.; Mikolasevic, Ivana; Mani, Arya; Oliveira, Jefferson Xavier de

doi:10.1902/jop.2016.160392

Cited by 34 publications

(90 citation statements)

References 33 publications

(99 reference statements)

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“…Our research team has previously demonstrated microvesicular steatosis in rats with periodontitis, but the increase in the number of binucleate hepatocytes in animals with periodontitis had not been previously reported in the literature by then. Nonetheless, binucleate hepatocytes stand out as an attempt by damaged hepatocytes to regenerate .…”

Section: Discussionsupporting

confidence: 92%

“…Regarding measures of steatosis ( p < 0.05), the mean values for inflammation and necrosis scores were higher for rats with periodontitis than for rats without periodontitis, ( p > 0.05), which is consistent with previous studies, again confirmed here by our research team. We did not find macrovesicular steatosis or hepatic fibrosis in the livers.…”

Section: Discussionsupporting

confidence: 63%

“…Experimental periodontitis was performed with intramuscular solution of 2% xylazine hydrochloride (15 mg/Kg) (Rompum‐Bayer ® , São Paulo, SP, Brazil) and ketamine (40 mg/Kg) (Francotar‐Virbac ® , Roseira, SP, Brazil). A nylon ligature 3‐0 (Shalon ® , Goiania, GO, Brazil), was inserted around the 1st lower molar of each animal bilaterally . After 20 days, rats were euthanized and blood was collected for biochemical tests.…”

Section: Methodsmentioning

confidence: 99%

“…The livers of the rats were collected from the left lobe and routinely processed according to Vasconcelos et al …”

Section: Methodsmentioning

confidence: 99%

“…Periodontitis not only causes injury to the periodontal tissues but also damages other tissues such as: articulate, renal, cardiac, and hepatic …”

mentioning

confidence: 99%

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