Decrease of ischaemia-reperfusion related lung oedema by continuous ventilation and allopurinol in rat perfusion lung model

Okuda, Masahiro; Furuhashi, Kazuhisa; Nakai, Yasushi; Muneyuki, Mannosuke

doi:10.1080/00365519309092563

Scand J Clin Lab Invest

1993

DOI: 10.1080/00365519309092563

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Decrease of ischaemia-reperfusion related lung oedema by continuous ventilation and allopurinol in rat perfusion lung model

Masahiro Okuda

Kazuhisa Furuhashi

Yasushi Nakai

et al.

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Cited by 4 publications

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“…Several investigators have found that subjecting the ischemic pulmonary vasculature to mechanical strains can have an ameliorating effect on the injury following reperfusion (3,26,39). For example, either ventilatory stretch (with or without oxygen) or increased static intravascular pressure during ischemia attenuated the increased vascular permeability after reperfusion (39).…”

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Effect of time and vascular pressure on permeability and cyclic nucleotides in ischemic lungs

Pearse

Becker

2000

American Journal of Physiology-Heart and Circulatory Physiology

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We previously found that increased intravascular pressure decreased ischemic lung injury by a nitric oxide (NO)-dependent mechanism (Becker PM, Buchanan W, and Sylvester JT. J Appl Physiol 84: 803-808, 1998). To determine the role of cyclic nucleotides in this response, we measured the reflection coefficient for albumin (sigma(alb)), fluid flux (), cGMP, and cAMP in ferret lungs subjected to either 45 min ("short"; n = 7) or 180 min ("long") of ventilated ischemia. Long ischemic lungs had "low" (1-2 mmHg, n = 8) or "high" (7-8 mmHg, n = 6) vascular pressure. Other long low lungs were treated with the NO donor (Z)-1-[N-(3-ammoniopropyl)-N-(n-propyl)amino]diazen-1-ium -1, 2-diolate (PAPA-NONOate; 5 x 10(-4) M, n = 6) or 8-bromo-cGMP (5 x 10(-4) M, n = 6). Compared with short ischemia, long low ischemia decreased sigma(alb) (0.23 +/- 0.04 vs. 0.73 +/- 0.08; P < 0.05) and increased (1.93 +/- 0.26 vs. 0.58 +/- 0.22 ml. min(-1). 100 g(-1); P < 0.05). High pressure prevented these changes. Lung cGMP decreased by 66% in long compared with short ischemia. Lung cAMP did not change. PAPA-NONOate and 8-bromo-cGMP increased lung cGMP, but only 8-bromo-cGMP decreased permeability. These results suggest that ischemic vascular injury was, in part, mediated by a decrease in cGMP. Increased vascular pressure prevented injury by a cGMP-independent mechanism that could not be mimicked by administration of exogenous NO.

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confidence: 99%

Effect of time and vascular pressure on permeability and cyclic nucleotides in ischemic lungs

Pearse

Becker

2000

American Journal of Physiology-Heart and Circulatory Physiology

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Attenuation of ischemia reperfusion-induced lung edema by prostaglandin I2 analogue OP-2507 in the isolated perfused rat lung

et al. 1994

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Using the physiological salt solution (PSS)/Ficollperfused rat lung, we studied the effect of prostaglandin I (PGI) analogue, OP-2507, on ischemia-reperfusion lung injury. Ischemia was induced by stopping perfusion and ventilation. Reperfusion after 90 min of normothermic ischemia increased mean pulmonary artery perfusion pressure (Ppa) and produced significant lung edema. Pretreatment with OP-2507 (200 ng·ml and 1000 ng·ml) equally attenuated the increase in Ppa and lung edema after reperfusion. Lactate dehydrogenase release from the OP-2507-treated lungs of both doses were significantly lower than the untreated lungs. Thus, OP-2507 seems to be a useful agent for preventing ischemia-reperfusion lung injury.

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Effect of pharmacological interventions in the prevention of lipid peroxidation and respiratory depression induced by oxygen free radicals in anesthetized rats

Jacinto

Lokhandwala

Jandhyala

1996

Free Radical Biology and Medicine

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Decrease of ischaemia-reperfusion related lung oedema by continuous ventilation and allopurinol in rat perfusion lung model

Cited by 4 publications

References 15 publications

Effect of time and vascular pressure on permeability and cyclic nucleotides in ischemic lungs

Effect of time and vascular pressure on permeability and cyclic nucleotides in ischemic lungs

Attenuation of ischemia reperfusion-induced lung edema by prostaglandin I2 analogue OP-2507 in the isolated perfused rat lung

Effect of pharmacological interventions in the prevention of lipid peroxidation and respiratory depression induced by oxygen free radicals in anesthetized rats

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