Effect of pharmacological interventions in the prevention of lipid peroxidation and respiratory depression induced by oxygen free radicals in anesthetized rats

Effect on rat arterial blood pressure of chemically generated peroxyl radicals and protection by antioxidants

“…This hypotensive effect is in agreement with findings obtained by Jacinto et al in a study using anion superoxide as the oxidizing agent [21]. To investigate whether the hypotensive effect of peroxyl radicals could be prevented by antioxidant bolus infusion, we selected three different types of antioxidants: ␣-tocopherol, ascorbic acid, and glutathione (GSH) at concentrations similar to physiological values.…”

Short-term exercise training improves diaphragm antioxidant capacity and endurance

“…It has been found that extensive lipid peroxidation in cells can result in a loss of cellular homeostasis resulting from impaired function of membrane bound receptors, ion channels, and reduced enzyme activity (Halliwell and Gutteridge 1990;Kukreja and Hess 1992). This has been considered to be physiologically signi®cant because oxidative damage to myocytes is associated with contraction dysfunction, including reduced maximal tension, reduced rate of force development and early onset of fatigue (Shindoh et al 1990;Reid et al 1993;Anzueto et al 1994;Jacinto et al 1996;Supinski 1998).…”

Effects of Dopexamine on Lipid Peroxidation During Aortic Surgery in Pigs: Comparison with Dopamine

“…9,12,13 Furthermore, this agent significantly decreased plasma lipid peroxides in freeradical induced respiratory toxicity in rats. 10 Cabergoline, a dopamine agonist, has been found to have synergistic antioxidant activity with vitamin E, when administered to patients with Parkinsons disease. 11 The antioxidant effects of dopexamine are mediated specifically via adrenergic receptors.…”

“…[5][6][7][8] Furthermore, some investigators suggest that dopexamine used in experimental models can prevent lipid peroxidation induced by oxygen free radicals. 9,10 Antioxidant activity on the other hand, has been attributed to cabergoline, a dopamine agonist, administered in Parkinsons disease. 11 The present experimental study in pigs deals with the dose-related effect of dopexamine and dopamine on free radical production and subsequent lipid peroxidation estimated by MDA measurements during an ischemia-reperfusion model of supraceliac aortic repair.…”