Decrease of Histaminase in Tissue by Adrenalectomy and Its Restoration by Cortico-Adrenal Extract

Karady, S.; Rose, B.; Browne, J. S. L.

doi:10.1152/ajplegacy.1940.130.3.539

Cited by 31 publications

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“…The differences may have been due to differences in the degree of sensitization or to differences in amount of histamine or histaminase in the tissues after adrenalectomy (Karady, Rose & Browne, 1940;Rose & Browne, 1941;Valette & Huidobro, 1957;Hicks & West, 1958;Bartlet & Lockett, 1959). SUMMARY 1.…”

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“…In general, the degree of anaphylactic shock, the concentration of histamine, and the histamine-destroying power of the blood were less in rats sensitized after adrenalectomy than in rats sensitized with the aid of Bordetella (haemophilus) pertus8is vaccine. The differences may have been due to differences in the degree of sensitization or to differences in amount of histamine or histaminase in the tissues after adrenalectomy (Karady, Rose & Browne, 1940;Rose & Browne, 1941;Valette & Huidobro, 1957;Hicks & West, 1958;Bartlet & Lockett, 1959). SUMMARY 1.…”

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The simultaneous release of histamine and a histamine‐destroying factor during anaphylaxis in rats

Code¹,

Cody²,

Hurn³

et al. 1961

The Journal of Physiology

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Mota (1957Mota ( , 1958 has demonstrated that the concentration of histamine in the plasma of rats is increased during anaphylactic shock. He used alum-precipitated horse serum or Bordetella (haemophilu8) pertU8sis vaccine as adjuvants to aid the development of the supersensitivity. Maruno (1958b) has shown that the concentration of histamine in the whole blood of rats previously injected with horse serum alone is greater after challenge with the serum than in control unsensitized animals. The objectives of this study were, first, to confirm the release of histamine during anaphylactic shock in pertussis-vaccinated rats; secondly, to explore the possibility of a simultaneous release of a histamine-destroying factor in such rats as has been shown already for rabbits by Rose & Leger (1952); and, finally, to determine whether release of histamine and a histamine-destroying factor occurred in anaphylactic shock in rats rendered susceptible to sensitization by adrenalectomy instead of by the use of adjuvants. METHODSHealthy white male rats of the Sprague-Dawley strain, weighing 150-250 g, were used in all experiments. The intact animals were sensitized by a single intraperitoneal injection of 25 mg crystalline ovalbumin dissolved in 1 ml. NaCl solution, 0-9 g/100 ml. This was combined in the syringe for injection with 05 ml. of a saline suspension of phase-i Bordetella (haemophilus) pertussis vaccine containing approximately 30 x 109 killed pertussis organisms. The adrenalectomized rats were sensitized by the subcutaneous injection of 0-5 ml. of sterile horse serum given on four consecutive days without the addition of pertussis vaccine. Rats sensitized to ovalbumin were challenged by the intravenous injection of 3-7 mg of the crystalline protein dissolved in 0-25-058 ml. of 0-9 % NaCl solution. One millilitre of the undiluted horse serum was used as the challenging intravenous injection for the adrenalectomized animals.Anaesthesia was induced by the inhalation of ether or by intraperitoneal injection of pentobarbital sodium 4 mg/100 g body weight. The adrenal glands were removed through a single dorsal mid line incision at the level of the kidneys. The glands were approached 14PHYSIO. CLVI

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The simultaneous release of histamine and a histamine‐destroying factor during anaphylaxis in rats

Code¹,

Cody²,

Hurn³

et al. 1961

The Journal of Physiology

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“…However, the role of this enzyme on the depletion of tissue histamine of the irradiated animals has not received adequate attention. On the other hand, it is also known that irradiation of animals causes an activation of the adrenocortical function (6,7), and that corticoid might affect the tissue histamine level (8-11) through its enhancing effect on histaminase activity (8, 11). Thus, in the present study, attempts have been made to examine (a) the relationship between the histamine contents and the histaminase activities of a variety of tissues and organs of irradiated rats and (b) the role of corticoid on the histaminase activity of the lung of irradiated as well as nonirradiated, adrenalectomized rats.…”

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Role of Histaminase and Corticosterone on the Depletion of Tissue Histamine in the Irradiated Rats

Kobayashi

1974

Experimental Biology and Medicine

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“…(246), (e) decreased glucose absorption (9), (f) hypoglycemia (86,195,356 The insufficient patient or experimental animal has been shown to respond with an increased susceptibility and sensitivity to poisons, drugs, bacterial toxins (119), histamine (due to lack of cortex and medulla) (138,170,224,337), potassium (364), exercise, fatigue (137), infection (119), low oxygen pressure (175), water intoxication (87,295,301), trauma, hemorrhage (even if trivial) (293,298), various types of shock and any procedure which throws a strain on the peripheral circulation (292), temperature changes (342,348), thyroxin (175), insulin (175), theelin, phlorhizin (176).…”

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The behavior of adrenocortical transplants in the rat under the influence of ingested sodium and potassium salts

Plachte¹

1942

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Vous enfin, dele'gue's des nations etrangeres, qui §tes venus de si loin donner une preuve de sympathie a la France, vous m'apportez la joie la plus profonde que puisse gprouver un homme qui croit invincib lenient que la science et gland that could meet the needs of the patient's bodily economy would be close to the ideal state, the normal gland.The outspoken unsuitability of pancreatic tissue for any kind of grafting and the lack of therapeutic success in the case of adrenal transplantation have shattered the hopes of the profession for ever attaining the goal of successful therapeutic application. This, however, does not justify the abandonment of transplantation research. On the contrary, it will, now more than ever, mean that the whole field of endocrine transplantation will have to be revised and put on a sound physiological basis.The older literature about organ transplantation in general and with reference to the adrenals has been reviewed by Knauer (180)?The therapeutic transplantation of adrenal tissue will be considered separately in Appendix D.* The numbers refer to the bibliography at the end of the dissertation. Grawitz's and Cohnheim's ideas about the genesis of neoplasms in general and adrenal tumors in particular, it was attempted to produce new adrenal growths by stalked transplants in dogs cats, and rabbits (105, 106, 108,283) and by free transplantation in rabbits, guinea pigs, and rats (324,178,219,258,259). This was done in order to reproduce a situation which was believed to exist in a tumor-bearing organism.At this point a general remark about free and stalked grafts should be made.The stalked grafts as they were frequently performed in dogs, rabbits, and cats (75, 105-108, 225, 283) Adrenal pseudotransplantation shall not be considered in this paper unless specifically mentioned. Likewise, procedures such as that of leaving the gland in its normal bed after demedullating it or ligating its blood supply (558) will not be discussed. Furthermore, some work (4) is so inadequate in planning and execution that it will not be included. The following problems were approached by this method:the relation of the adrenal to the susceptibility of the organism to histamine (537,344,345,353), anaphylactic shock (339), resistance (162), blood volume (343), blood KPN and urea (357), blood sugar level (349,356), temperature regulation (342,348), arterial lesions (187), spontaneous activity (242), mineral metabolism (247), early sex development (220), the mechanism of vascular responses to adrenalin and of adrenalin intoxication (346,350,354), adrenalininduced lens opacities (312).Moreover, the host-donor tissue compatibility and the differentials of individuality, organs, and species (191)(192)(193)(194) were extensively investigated by means of transplantation of adrenal tissue among others. The influence of ultracentrifugation upon specialized tissues and their viability and 6 and functional capacity as grafts were also investigated with adrenal transplantation (77,78). . Factgrs_inf^u §ncinj;_th^_f...

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Decrease of Histaminase in Tissue by Adrenalectomy and Its Restoration by Cortico-Adrenal Extract

Cited by 31 publications

References 0 publications

The simultaneous release of histamine and a histamine‐destroying factor during anaphylaxis in rats

The simultaneous release of histamine and a histamine‐destroying factor during anaphylaxis in rats

Role of Histaminase and Corticosterone on the Depletion of Tissue Histamine in the Irradiated Rats

The behavior of adrenocortical transplants in the rat under the influence of ingested sodium and potassium salts

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