The behavior of adrenocortical transplants in the rat under the influence of ingested sodium and potassium salts

Abstract

Vous enfin, dele'gue's des nations etrangeres, qui §tes venus de si loin donner une preuve de sympathie a la France, vous m'apportez la joie la plus profonde que puisse gprouver un homme qui croit invincib lenient que la science et gland that could meet the needs of the patient's bodily economy would be close to the ideal state, the normal gland.The outspoken unsuitability of pancreatic tissue for any kind of grafting and the lack of therapeutic success in the case of adrenal transplantation have shattered the hopes of the profession for ever attaining the goal of successful therapeutic application. This, however, does not justify the abandonment of transplantation research. On the contrary, it will, now more than ever, mean that the whole field of endocrine transplantation will have to be revised and put on a sound physiological basis.The older literature about organ transplantation in general and with reference to the adrenals has been reviewed by Knauer (180)?The therapeutic transplantation of adrenal tissue will be considered separately in Appendix D.* The numbers refer to the bibliography at the end of the dissertation. Grawitz's and Cohnheim's ideas about the genesis of neoplasms in general and adrenal tumors in particular, it was attempted to produce new adrenal growths by stalked transplants in dogs cats, and rabbits (105, 106, 108,283) and by free transplantation in rabbits, guinea pigs, and rats (324,178,219,258,259). This was done in order to reproduce a situation which was believed to exist in a tumor-bearing organism.At this point a general remark about free and stalked grafts should be made.The stalked grafts as they were frequently performed in dogs, rabbits, and cats (75, 105-108, 225, 283) Adrenal pseudotransplantation shall not be considered in this paper unless specifically mentioned. Likewise, procedures such as that of leaving the gland in its normal bed after demedullating it or ligating its blood supply (558) will not be discussed. Furthermore, some work (4) is so inadequate in planning and execution that it will not be included. The following problems were approached by this method:the relation of the adrenal to the susceptibility of the organism to histamine (537,344,345,353), anaphylactic shock (339), resistance (162), blood volume (343), blood KPN and urea (357), blood sugar level (349,356), temperature regulation (342,348), arterial lesions (187), spontaneous activity (242), mineral metabolism (247), early sex development (220), the mechanism of vascular responses to adrenalin and of adrenalin intoxication (346,350,354), adrenalininduced lens opacities (312).Moreover, the host-donor tissue compatibility and the differentials of individuality, organs, and species (191)(192)(193)(194) were extensively investigated by means of transplantation of adrenal tissue among others. The influence of ultracentrifugation upon specialized tissues and their viability and 6 and functional capacity as grafts were also investigated with adrenal transplantation (77,78). . Factgrs_inf^u §ncinj;_th^_f...