Decrease of Gastrointestinal Mucosal Damage by Salicyluric Acid Compared with Salicylic Acid in Rabbits

Abstract

The gastrointestinal mucosal damage following the oral administration of salicylic acid or salicyluric acid was examined in rabbits using a scanning electron microscope. Six and 24 h after treatment with salicylic acid, morphological changes of gastric mucosa were recognized. In rabbits treated with salicyluric acid, however, severe damage in the gastric mucosa was not found after 24 h compared with the treatment with salicylic acid. Following the treatment with salicylic acid, some mucosal damage in the duodenum, jejunum and ileum was observed after 24 h. The surface character of the duodenal, jejunal, ileal, caecal and colonic mucosa were almost identical compared with the control following the treatment with salicyluric acid. It was reported that salicyluric acid is metabolized to salicylic acid by the intestinal microorganisms. From these results, it was suggested that prodrugs utilizing the metabolism of salicyluric acid to salicylic acid by intestinal microorganisms may be useful in reducing gastrointestinal mucosal damage.

Dietary protein source and butyrylated high-amylose maize starch included in a high-protein diet determines the urinary metabolome of rats

“…The existence of salicyluric acid has been reported in milk (Booth et al 1962). It can be metabolised to salicylic acid by intestinal microorganisms (Nakamura et al 1991), which has been shown to have CRC preventive traits (Paterson and Lawrence 2001). In our study, more salicylate was excreted in the urine of rats on LPW diet compared with LPM.…”