Decrease in the prevalence of extended-spectrum cephalosporin-resistant Salmonella following cessation of ceftiofur use by the Japanese poultry industry

Shigemura, Hiroaki; Matsui, Mari; Sekizuka, Tsuyoshi; Onozuka, Daisuke; Noda, Teppei; Yamashita, Akifumi; Kuroda, Makoto; Suzuki, Satowa; Kimura, Hirokazu; Fujimoto, Shuji; Oishi, Kazunori; Sera, Nobuyuki; Inoshima, Yasuo; Murakami, Koichi

doi:10.1016/j.ijfoodmicro.2018.03.011

Cited by 30 publications

(41 citation statements)

References 26 publications

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“…As most Salmonella infections are associated with consumption of meats, milk, and eggs, the veterinary use of antimicrobials, especially those important for treatment of humans, has long been a contentious issue (Cox and Ricci, 1969). While there is epidemiological data to support the link between antimicrobial use and resistance (Bortolaia et al, 2015;Noyes et al, 2016;Andersen et al, 2017;Caffrey et al, 2017;Shigemura et al, 2018), it is generally difficult to ascertain causal effect depending on the antimicrobial (Fairchild et al, 2005;Smith et al, 2007;Agga et al, 2016), food animal (Agga et al, 2016), level or scope of food animal production system (Idris et al, 2006;Andersen et al, 2017;Liljebjelke et al, 2017), or method of quantifying resistance (Fairchild et al, 2005;Smith et al, 2007;Agga et al, 2016). In poultry production, the antimicrobials available for use in the US are limited to 15 drugs (Singer and Hofacre, 2006).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Resistant Salmonella enterica Typhimurium Colonizing Chickens: The Impact of Plasmids, Genotype, Bacterial Communities, and Antibiotic Administration on Resistance

Bythwood

Soni

Lyons

et al. 2019

Front. Sustain. Food Syst.

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The rise in Salmonella resistance to cephalosporins and fluoroquinolones has become a significant threat to public health. At issue, is whether agricultural use of antimicrobials is selecting antibiotic resistance in Salmonella and the degree to which large antimicrobial resistance gene reservoirs, present in animal manures, contribute to this resistance. Two in vivo studies were performed to address these questions. In the first study, chickens were administered Salmonella and commensals, including an Escherichia coli strain with a mobile, ceftiofur-resistance plasmid, in order to determine how antibiotic administration impacted resistance in E. coli and Salmonella. All antibiotics administered to chickens increased streptomycin resistance in E. coli. However, only ceftiofur administration increased resistance in Salmonella and specifically to extended-spectrum β-lactams and cephalosporins (ESBL). There was no significant increase in ESBL-resistant Salmonella in chickens administered a ceftiofur-resistance plasmid donor. In the second study, chickens were administered two different isolates of S. enterica Typhimurium and a chicken resistome to serve as a gene donor. Birds were subsequently administered chlortetracycline or streptomycin. Antimicrobial administration significantly altered aminoglycoside and tetracycline resistance in the Enterobacteriaceae population. However, there was no significant increase in antimicrobial resistant Salmonella. Administration of a chicken resistome had no significant impact on prevalence of resistance in Enterobacteriaceae populations, including Salmonella. Evident, from both studies, was that these treatments had minimal effect on increasing the prevalence of resistance in Salmonella, suggesting that other factors may be more important in dissemination of antimicrobial resistant Salmonella in chickens.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Resistant Salmonella enterica Typhimurium Colonizing Chickens: The Impact of Plasmids, Genotype, Bacterial Communities, and Antibiotic Administration on Resistance

Bythwood

Soni

Lyons

et al. 2019

Front. Sustain. Food Syst.

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“…The reduction of β-lactam resistance proportion in our study may be the same as reported by Mauro et al [16], where the authors indicated that the off-label use of ceftiofur with Marek's vaccine is associated with the short-term increase in ESBL-producing Escherichia coli in the gut of broiler chickens. In Japan, the same situation appeared following the cessation of ceftiofur use by the Japanese poultry industry [22]. Figure 1 shows a comparison of the specific antimicrobial resistance rates for S. Infantis (Fig.…”

Section: Schwarzengrund Has Been Reported As An Emerging Pathogen In mentioning

confidence: 80%

Increased <i>Salmonella</i> Schwarzengrund prevalence and antimicrobial susceptibility of <i>Salmonella enterica</i> isolated from broiler chickens in Kagoshima Prefecture in Japan between 2013 and 2016

et al. 2020

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This study aimed to analyze the Salmonella serovars, measure the minimum inhibitory concentration of antimicrobials, and examine the antimicrobial resistance genes of Salmonella isolated from 192 broiler flocks in Kagoshima Prefecture in Japan, from 2013 to 2016. We found that all Salmonella isolates belonged to three serovars: Salmonella Manhattan, S. Infantis, and S. Schwarzengrund. Among them, S. Schwarzengrund prevalence has recently increased annually making the main serovar. Most recovered isolates were highly resistant to streptomycin, sulfamethoxazole, and oxytetracycline. We saw the reduction of third-generation cephalosporin resistance and identified the reason of increased kanamycin resistance to be the increased number of S. Schwazengrund isolates. Among the kanamycin-resistant Salmonella isolates, aphA1 constituted the main resistance gene detected.

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“…The apparent correlation between reductions in ceftiofur use and reduced prevalence of ceftiofur resistance in Salmonella or E. coli has been demonstrated by other countries. For example, in Japan, the prevalence of extended-spectrum cephalosporin-resistant Salmonella in chicken meat was 45% in 2011 [168]. In March 2012, the Japanese poultry industry voluntarily ceased using ceftiofur and subsequently the prevalence of resistant Salmonella decreased yearly to 11% in 2015 [168].…”

Section: Results (Headings As Per the Codex Guidelines)mentioning

confidence: 99%

Ceftiofur-resistant Salmonella enterica serovar Heidelberg of poultry origin – a risk profile using the Codex framework

Carson

Agunos

et al. 2019

Epidemiol. Infect.

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Codex published the ‘Guidelines for Risk Analysis of Foodborne Antimicrobial Resistance’ to standardise the approach for evaluating risk posed by foodborne antimicrobial-resistant bacteria. One of the first steps in the guidelines is to compile a risk profile, which provides the current state of knowledge regarding a food safety issue, describes risk management options and recommends next steps. In Canada, ceftiofur/ceftriaxone-resistant Salmonella enterica subsp. enterica serovar Heidelberg from poultry was identified as an antimicrobial resistance (AMR) food safety issue. The first objective of this article was to contextualise this food safety issue, using the risk profile format of the Codex Guidelines. A second objective was to evaluate the applicability of the Codex Guidelines. This risk profile indicated that ceftiofur/ceftriaxone-resistant S. Heidelberg (CSH) was commonly isolated from poultry and was associated with severe disease in humans. Ceftiofur use in poultry hatcheries temporally mirrored the prevalence of CSH from poultry meat at retail and from people with salmonellosis. The evidence was sufficient to indicate the need for risk management options, such as restricting the use of ceftiofur in poultry. The Codex Guidelines provided a useful approach to summarise data for decision-makers to evaluate an AMR food safety issue.

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Decrease in the prevalence of extended-spectrum cephalosporin-resistant Salmonella following cessation of ceftiofur use by the Japanese poultry industry

Cited by 30 publications

References 26 publications

Antimicrobial Resistant Salmonella enterica Typhimurium Colonizing Chickens: The Impact of Plasmids, Genotype, Bacterial Communities, and Antibiotic Administration on Resistance

Antimicrobial Resistant Salmonella enterica Typhimurium Colonizing Chickens: The Impact of Plasmids, Genotype, Bacterial Communities, and Antibiotic Administration on Resistance

Increased <i>Salmonella</i> Schwarzengrund prevalence and antimicrobial susceptibility of <i>Salmonella enterica</i> isolated from broiler chickens in Kagoshima Prefecture in Japan between 2013 and 2016

Ceftiofur-resistant Salmonella enterica serovar Heidelberg of poultry origin – a risk profile using the Codex framework

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