Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8

Li, Mingyue; Li, Xinyuan; Goldsmith, Jason R.; Shi, Shengqing; Zhang, Li; Zamani, Ali; Wan, Lin; Sun, Honghong; Li, Ting; Yu, Ji‐Yeon; Etwebi, Zienab; Bou‐Dargham, Mayassa J.; Chen, Youhai H.

doi:10.1038/s41388-021-02035-6

Cited by 7 publications

(2 citation statements)

References 42 publications

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“…Its overexpression is positively associated with the development of various cancers, including liver, lung, and breast cancers(Lou et al, 2022; Niture et al, 2018). However, Chen et al reported that TIPE initially inhibits cancer cell proliferation but promotes tumor migration and metastasis(Li et al, 2021). In addition, a previous report has demonstrated that TIPE functions as a tumor suppressor in certain inflammatory carcinogenesis(Lou et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

Tian,

Yang,

Zhao

et al. 2023

Preprint

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TIPE (TNFAIP8) has been identified as an oncogene and participates in tumor biology. However, how its role in the metabolism of tumor cells during melanoma development remains unclear. Here, we demonstrated that TIPE promoted glycolysis by interacting with pyruvate kinase M2 (PKM2) in melanoma. We found that TIPE induced PKM2 dimerization, thereby facilitating its translocation from the cytoplasm to the nucleus. TIPE-mediated PKM2 dimerization consequently promoted HIF-1α activation and glycolysis, which contributed to melanoma progression and increased its stemness features. Notably, TIPE specifically phosphorylated PKM2 at Ser 37 in an ERK-dependent manner. Consistently, the expression of TIPE was positively correlated with the levels of PKM2 Ser37 phosphorylation and cancer stem cell markers in melanoma tissues from clinical samples and tumor bearing mice. In summary, our findings indicate that the TIPE/PKM2/HIF-1α signaling pathway plays a pivotal role in promoting cancer stem cell properties by facilitating the glycolysis, which would provide a promising therapeutic target for melanoma intervention.

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Section: Discussionmentioning

confidence: 99%

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

Tian,

Yang,

Zhao

et al. 2023

Preprint

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“…By inhibiting tumor cell growth and proliferation by modulating the Hippo signaling pathway, TNFAIP8 works as a cellular “pilot” for tumor cell migration by boosting local phosphatidylinositol 3 kinase-protein kinase B and Rac signals on the cell membrane encountering chemoattractants. 34 , 35 In addition, TNF-α activates the NF-κB pathway to promote its expression, and TNFAIP8 mRNA expression is found in the head and neck, esophagus, breast, and lung tumors. 5 , 36 – 38 SNP rs11064 was found to be correlated to a greater risk of cervical cancer in women from the Eastern Chinese region as reported by Shi et al 11 Additionally, the results of the study imply that TNFAIP8 may serve as a valuable marker for reckoning platinum resistance and clinical outcomes in cervical cancer.…”

Section: Discussionmentioning

confidence: 99%

Susceptibility of TNFAIP8, TNFAIP8L1, and TNFAIP2 Gene Polymorphisms on Cancer Risk: A Comprehensive Review and Meta-Analysis of Case–Control Studies

Bhowmik

Barek

Aziz

et al. 2022

Technol Cancer Res Treat

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Objectives: The TNFAIP8 gene family and TNFAIP2 gene are inextricably linked to an elevated risk of cancer development. This systemic review and meta-analysis seeks to establish the relationship between TNFAIP8 (rs11064, rs1045241, rs1045242, and rs3813308), TNFAIP8L1 (rs1060555), and TNFAIP2 (rs710100 and rs8126) polymorphisms with the risk of cancer. Methods and Materials: A systematic search of multiple databases from January 2022 to April 2022 was used to identify relevant studies. Odds ratios (ORs) with corresponding 95% CI and p-value were calculated to assess the association. Bonferroni correction was performed to correct p-values. Trial sequential analysis (TSA) and in-silico messenger RNA expression were also performed. Review Manager 5.4 software was used for performing this meta-analysis. Results: This study comprised 6909 cancer patients and 7087 healthy participants from 14 studies. Four genetic models of rs11064 (codominant 2 [COD2]: OR = 2.30, p = 7.83 × 10−5; codominant 3 [COD3]: OR = 2.10, p = .0006; recessive model [RM]: OR = 2.24, p = .0001; AC: OR = 1.47, p = .037), two genetic models of rs1045241 (codominant 1 [COD1]: OR = 1.27, p = .009; overdominant model [ODM]: OR = 1.24, p = .018), four genetic models of rs1045242 (COD1: OR = 1.52, p = .005; dominant model (DM): OR = 1.56, p = .002; OD: OR = 1.48, p = .008; AC: OR = 1.48, p = .002), and three genetic models of rs8126 (COD2: OR = 1.41, p = .0005; COD3: OR = 1.44, p = .0002; RM: OR = 1.43, p = .0001) were statistically linked to cancer risk. Only one genetic model of rs1060555 polymorphism showed a significant protective association with cancer (COD2: OR = 0.80, p = .048). The outcomes of TSA also validated the findings of the meta-analysis. Conclusion: This study summarizes that rs11064, rs1045241, and rs1045242 polymorphisms of TNFAIP8 gene and rs8126 polymorphism of TNFAIP2 gene are significantly linked with the risk of cancer development. This meta-analysis was registered at INPLASY (registration number: INPLASY202270073).

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TNFAIP8 overexpression aggravates retinal pathophysiological features of diabetic retinopathy

Yang

Zhang

et al. 2023

Experimental Eye Research

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Decoupling tumor cell metastasis from growth by cellular pilot protein TNFAIP8

Cited by 7 publications

References 42 publications

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

TIPE drives a cancer stem-like phenotype by promoting glycolysis via PKM2/HIF-1α axis in melanoma

Susceptibility of TNFAIP8, TNFAIP8L1, and TNFAIP2 Gene Polymorphisms on Cancer Risk: A Comprehensive Review and Meta-Analysis of Case–Control Studies

TNFAIP8 overexpression aggravates retinal pathophysiological features of diabetic retinopathy

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