Decorin regulates endothelial cell-matrix interactions during angiogenesis

Fiedler, Lorna R.; Eble, Johannes A.

doi:10.4161/cam.3.1.7275

Cited by 27 publications

(29 citation statements)

References 29 publications

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“…Electron microscopic studies of chick, mouse, rabbit, and sea urchin embryos reveal that prospective mesenchymal cells often take on a bottle shaped morphology as they leave an epithelium (Katow, 1980; Tam et al, 1993; Viebahn et al, 1995; Nakaya and Sheng, 2009). Time-lapse movies of sea urchin embryos reveal that this apical constriction is the mechanism by which primary mesenchyme cells ingress (Wu et al, 2007), and it is a likely mechanism for ingression within the primitive streak of amniotes.…”

Section: Resultsmentioning

confidence: 99%

“…RhoA activity has been shown to regulate BL integrity, and thereby EMT, but many other cellular and molecular mechanisms underlying primitive streak EMT in the chick are not well understood. Electron micrographs have shown that epiblast cells acquire a bottle shape within the streak (Nakaya and Sheng, 2009), strongly suggesting apical constriction as a method of ingression. The subsequent migration of mesoderm away from the streak has been more thoroughly studied (Yang et al, 2002; Hardy et al, 2008; Sweetman et al, 2008; Yang et al, 2008; Yue et al, 2008), however the intermediate steps between streak condensation and mesoderm migration are not well understood.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mouse primitive streak forms in situ by initiation of epithelial to mesenchymal transition without migration of a cell population

Williams¹,

Burdsal²,

Periasamy³

et al. 2011

Developmental Dynamics

127

151

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During gastrulation, an embryo acquires the three primordial germ layers that will give rise to all of the tissues in the body. In amniote embryos, this process occurs via an epithelial to mesenchymal transition (EMT) of epiblast cells at the primitive streak. Although the primitive streak is vital to development, many aspects of how it forms and functions remain poorly understood. Using live imaging and immunohistochemistry, we have shown that the murine primitive streak arises in situ by progressive initiation of EMT beginning in the posterior epiblast, without large-scale movement or convergence and extension of epiblast cells. Loss of basal lamina (BL) is the first step of this EMT, and is strictly correlated with ingression of nascent mesoderm. This is the first description of dynamic cell behavior during primitive streak formation in the mouse embryo, and reveals mechanisms that are quite distinct from those observed in other amniote model systems.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mouse primitive streak forms in situ by initiation of epithelial to mesenchymal transition without migration of a cell population

Williams¹,

Burdsal²,

Periasamy³

et al. 2011

Developmental Dynamics

127

151

View full text Add to dashboard Cite

show abstract

“…DCN also suppresses the pro-angiogenic factor HIF-1α and up regulates the anti-angiogenic factors TIMP3 and thrombospondin 1 in HIF-1α-overexpressing MDA-MB-231 cells [63], and its loss could contribute to the increased angiogenesis in the holoclone-derived H460 tumors. DCN can also promote angiogenesis in wound healing, postnatal angiogenesis, corneal angiogenesis, and inflammation-induced angiogenesis, and it regulates endothelial cell-matrix interaction through endothelial cells [64]. Decreases in expression of DCN and LUM, as seen in our H460 holoclone-derived tumors, are associated with poor prognosis and shorter time to tumor progression in breast cancer [65].…”

Section: Discussionmentioning

confidence: 99%

H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity

Manley

Waxman

2014

Cancer Letters

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Cancer stem-like cells were isolated from several human tumor cell lines by limiting dilution assays and holoclone morphology, followed by assessment of self-renewal capacity, tumor growth, vascularity, and blood perfusion. H460 holoclone-derived tumors grew slower than parental H460 tumors, but displayed significantly increased microvessel density and tumor blood perfusion. Microarray analysis identified 177 differentially regulated genes in the holoclone-derived tumors, of which 47 were associated with angiogenesis. The dysregulated genes include several small leucine-rich proteoglycans that may modulate angiogenesis and serve as novel therapeutic targets for inhibiting cancer stem cell-driven angiogenesis.

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“…It is expressed in most collagen-rich mesenchymal tissues and up-regulated during angiogenesis of different conditions, especially in inflammatory processes [7]. In addition, decorin has been shown to regulate endothelial cell-matrix interactions during angiogenesis [5]. Furthermore, a current publication on benign and malignant vascular tumors demonstrated that expression patterns of decorin were differed from malignant to benign vascular tumors [4].…”

Section: Discussionmentioning

confidence: 99%

“…However, several studies have revealed that the lesion is not a neoplasm possessing metastatic potential, but a reactive cellular proliferation [2]. Recently, the proteoglycan decorin was demonstrated to play a key role in angiogenesis in normal and tumor-associated endothelium [3][4][5]. In this study, we measured decorin expression immnohistochemically in 2 SCH cases and examine feasibility of decorin stating for distinguishing between SCH and malignant vascular tumors.…”

Section: Introductionmentioning

confidence: 99%

Spindle Cell Hemangioma and Decorin Expression

Rokunohe¹,

タケダ²,

Kaneko³

et al. 2012

JCDSA

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Spindle cell hemangioma (SCH) is a rare benign vascular tumor and we report 2 cases of SCH who are 50-year-old man and 16-year-old girl. A growing amount of evidence indicates that multifunctional ECM molecule decorin regulate endothelial cell-matrix interactions during angiogenesis. Furthermore, a current publication shows that no detectable decorin expression was found in the stromas of tumor nests in Kaposi's sarcoma or angiosarcoma groups while the expression was clearly observed in the connective tissue stromas within benign vascular tumors. SCH exhibits spindle cell proliferation and resembles Kaposi's sarcoma. Therefore, this study examined decorin expression in the tissues of our SCH cases by immunohistochemical analysis. The results demonstrated that immunoreactivity of decorin was clearly detectable in the connective tissue stroma within tumor nests. SCH was first perceived as sarcoma because of spindle cell proliferation, but this proliferation was subsequently found to be reactive. The presence of decorin expression in our cases also indicates that SCH have benign properties. Moreover, this study further increases the reliability of examination of decorin expression for differentiation between benign and malignant vascular tumors.

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Decorin regulates endothelial cell-matrix interactions during angiogenesis

Cited by 27 publications

References 29 publications

Mouse primitive streak forms in situ by initiation of epithelial to mesenchymal transition without migration of a cell population

Mouse primitive streak forms in situ by initiation of epithelial to mesenchymal transition without migration of a cell population

H460 non-small cell lung cancer stem-like holoclones yield tumors with increased vascularity

Spindle Cell Hemangioma and Decorin Expression

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