Mouse primitive streak forms in situ by initiation of epithelial to mesenchymal transition without migration of a cell population

Williams, Margot; Burdsal, Carol A.; Periasamy, Ammasi; Lewandoski, Mark; Sutherland, Ann

doi:10.1002/dvdy.23711

Cited by 127 publications

(165 citation statements)

References 60 publications

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“…Indeed, it has been shown in both chick and mouse embryos that the first morphologically apparent change in mesoderm cells within the primitive streak is a breakdown of the basement membrane underlying these cells Williams et al 2012). Following this, the cells ingress, and this occurs concurrently with a downregulation of E-cadherin and apico-basal and tight junction proteins.…”

Section: The Array Of Epithelial Phenotypes With Respect To Emtmentioning

confidence: 99%

A common framework for EMT and collective cell migration

2016

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During development, cells often switch between static and migratory behaviours. Such transitions are fundamental events in development and are linked to harmful consequences in pathology. It has long been considered that epithelial cells either migrate collectively as epithelial cells, or undergo an epithelial-to-mesenchymal transition and migrate as individual mesenchymal cells. Here, we assess what is currently known about in vivo cell migratory phenomena and hypothesise that such migratory behaviours do not fit into alternative and mutually exclusive categories. Rather, we propose that these categories can be viewed as the most extreme cases of a general continuum of morphological variety, with cells harbouring different degrees or combinations of epithelial and mesenchymal features and displaying an array of migratory behaviours.

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Section: The Array Of Epithelial Phenotypes With Respect To Emtmentioning

confidence: 99%

A common framework for EMT and collective cell migration

2016

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“…In these cases, changes in the geometry and mechanics of constituent cells appear to impact global tissue shape directly (Odell et al, 1981;Escudero et al, 2007;Sherrard et al, 2010;Eiraku et al, 2011). Apical constriction of individual cells can contribute to cell ingression from epithelial tissues, sometimes as a step in an epithelialmesenchymal transition (EMT) (Anstrom, 1992;Nance and Priess, 2002;Harrell and Goldstein, 2011;Williams et al, 2012). Apical constriction is also associated with the extrusion of apoptotic or delaminating cells (Toyama et al, 2008;Slattum et al, 2009;Marinari et al, 2012) and wound contraction and healing (Davidson et al, 2002;Antunes et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Apical constriction: themes and variations on a cellular mechanism driving morphogenesis

2014

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Apical constriction is a cell shape change that promotes tissue remodeling in a variety of homeostatic and developmental contexts, including gastrulation in many organisms and neural tube formation in vertebrates. In recent years, progress has been made towards understanding how the distinct cell biological processes that together drive apical constriction are coordinated. These processes include the contraction of actin-myosin networks, which generates force, and the attachment of actin networks to cell-cell junctions, which allows forces to be transmitted between cells. Different cell types regulate contractility and adhesion in unique ways, resulting in apical constriction with varying dynamics and subcellular organizations, as well as a variety of resulting tissue shape changes. Understanding both the common themes and the variations in apical constriction mechanisms promises to provide insight into the mechanics that underlie tissue morphogenesis.

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“…The reptiles, the stem amniote lineage from which both the mammals and birds evolved, do not have a streak (Bertocchini et al, 2013). Furthermore, mammals and birds have been hypothesized to employ different cellular mechanisms to generate a streak (Arnold and Robertson, 2009;Chuai and Weijer, 2008;Stern, 2004;Voiculescu et al, 2007;Williams et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Decoupling of amniote gastrulation and streak formation reveals a morphogenetic unity in vertebrate mesoderm induction

Alev¹,

Wu²,

Nakaya³

et al. 2013

Development

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Mesoderm is formed during gastrulation. This process takes place at the blastopore in lower vertebrates and in the primitive streak (streak) in amniotes. The evolutionary relationship between the blastopore and the streak is unresolved, and the morphogenetic and molecular changes leading to this shift in mesoderm formation during early amniote evolution are not well understood. Using the chick model, we present evidence that the streak is dispensable for mesoderm formation in amniotes. An anamniote-like circumblastoporal mode of gastrulation can be induced in chick and three other amniote species. The induction requires cooperative activation of the FGF and Wnt pathways, and the induced mesoderm field retains anamniote-like dorsoventral patterning. We propose that the amniote streak is homologous to the blastopore in lower vertebrates and evolved from the latter in two distinct steps: an initial pan-amniote posterior restriction of mesoderm-inducing signals; and a subsequent lineage-specific morphogenetic modification of the pre-ingression epiblast.

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Mouse primitive streak forms in situ by initiation of epithelial to mesenchymal transition without migration of a cell population

Cited by 127 publications

References 60 publications

A common framework for EMT and collective cell migration

A common framework for EMT and collective cell migration

Apical constriction: themes and variations on a cellular mechanism driving morphogenesis

Decoupling of amniote gastrulation and streak formation reveals a morphogenetic unity in vertebrate mesoderm induction

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