Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications

Gorab, Mostafa Ghafori; Aliabadi, Hooman Aghamirza Moghim; Kashtiaray, Amir; Mahdavi, Mohammad; Bani, Milad Salimi; Etminan, Andisheh; Salehpour, Nabi; Eivazzadeh‐Keihan, Reza; Maleki, Ali

doi:10.1039/d2na00394e

Cited by 11 publications

(4 citation statements)

References 43 publications

(78 reference statements)

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“…was 100mg/mL 64 . Magnetic-hyperthermia: the sample SPIONs have a high Ms and a tiny particle size of 20nm for the efficient HT application methodology; this excess in heating is the basis for magnetic induction heating applications in cancer cell therapy, as reported in 65,66 . In short time, they were higher than [64][65][66] depending on the concentration, which indicates the high MS of SPIONs.…”

Section: Discussionmentioning

confidence: 99%

Green synthesis of biocompatible Fe 3 O 4 magnetic nanoparticles using Citrus Sinensis peels extract for their biological activities and magnetic- hyperthermia applications

El-Deeb

El-Raheem

Elbeltagi

2023

Preprint

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Plants include active chemicals known as phytochemicals and biomolecules that serve as decreasing and biostability factors for nanoparticle (NP) creation. Citrus Sinensis peels are rich in phenolics, flavonoids, antioxidants, and biophysical benefits. Herein, we prepared superparamagnetic iron oxide nanoparticles (SPIONs) by co-precipitation using Citrus Sinensis peel extract as a novel green synthesis method. The antioxidant, anti-inflammatory, dye degradation activities, and antimicrobial activities of Fe3O4 MNPs were investigated. Furthermore, the produced materials were characterized using FTIR, UV, TEM, VSM, and XRD analysis. The Fe3O4 MNPs showed higher antibacterial activities against multi antibiotic resistant bacterial strains: Escherichia coli, Streptococcus mutans, Candida albicans, Staphylococcus aureus, Bacillus subtilis, and Klebsiella pneumonia. The sample has generated a lot of attention in the scientific community for magnetic hyperthermia (MHT) applications. The maximum value of the specific absorption rate (SAR) was evaluated at sample concentrations of 10mg under the magnetic field condition. Additionally, these newly fabricated SPIONs virtually achieve significant execution under the alternating magnetic field (AMF) in fluid HT and are suitable for biomedical applications.

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Section: Discussionmentioning

confidence: 99%

Green synthesis of biocompatible Fe 3 O 4 magnetic nanoparticles using Citrus Sinensis peels extract for their biological activities and magnetic- hyperthermia applications

El-Deeb

El-Raheem

Elbeltagi

2023

Preprint

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show abstract

“…Magnetic-hyperthermia: The SPIONs have a high M S and a tiny particle size of 20 nm for the efficient HT application methodology; this excess in heating is the basis for magnetic induction heating applications in cancer cell therapy, as reported in 52 , 79 . In a short time, they were higher than 52 , 79 , 80 depending on the concentration, which indicates the high M S of SPIONs.…”

Section: Discussionmentioning

confidence: 99%

Green synthesis of biocompatible Fe3O4 magnetic nanoparticles using Citrus Sinensis peels extract for their biological activities and magnetic-hyperthermia applications

Eldeeb,

El-Raheem,

Elbeltagi

2023

Sci Rep

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Green synthesis of nanoparticles (NPs) is eco-friendly, biocompatible, cost-effective, and highly stable. In the present study, Citrus sinensis peel extract was utilized to the fabrication of superparamagnetic iron oxide nanoparticles (SPIONs). The fabricated SPIONs were first characterized using UV–Visible spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), Transmission electron microscopy (TEM), and vibrating sample magnetometer (VSM). The UV–Vis spectra analysis displayed a peak at 259 nm due to the surface plasmon resonance. The FTIR spectrum showed bands at 3306 cm−1, and 1616 cm−1 revealed the protein’s involvement in the development and capping of NPs. TEM analysis indicated that green synthesized SPIONs were spherical in shape with particle size of 20–24 nm. Magnetization measurements indicate that the synthesized SPIONs exhibited superparamagnetic behavior at room temperature. The antimicrobial activity, minimum inhibitory concentration (MIC), antioxidant potential, anti-inflammatory effect, and catalytic degradation of methylene blue by SPIONs were investigated in this study. Results demonstrated that SPIONs had variable antimicrobial effect against different pathogenic multi-drug resistant bacteria. At the highest concentration (400 μg/mL), SPIONs showed inhibition zones (14.7–37.3 mm) against all the target isolates. Furthermore, the MIC of synthesized SPIONs against Staphylococcus aureus, Streptococcus mutans, Bacillus subtilis, Escherichia coli, Klebsiella pneumonia, and Candida albicans were 3, 6.5, 6.5, 12.5, 50, 25 μg/mL, respectively. SPIONs exhibited strong antioxidant, anti-inflammatory, and catalytic dye degradation activities. Interestingly, Fe3O4 SPIONs shows optimum magnetic hyperthermia (MHT) techniques under an alternating magnetic field (AMF) measured in specific absorption rate (SAR) of 164, 230, and 286 W/g at concentrations 1, 5, and 10 mg/mL, respectively. Additionally, these newly fabricated SPIONs virtually achieve significant execution under the AMF in fluid MHT and are suitable for biomedical applications.

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“…Graphene oxide/Fe3O4/carboxymethyl cellulose/SF bionanocomposite was developed to address hyperthermia in cancer treatment. [89] Wu et al produced a hydrogel by reducing HAuCl4 salt in situ to incorporate gold nanoparticles into chitosan and SF hydrogel with a much faster gelation time, thus indicating the strong intermolecular interaction of the polymers [90] .…”

Section: Methodsmentioning

confidence: 99%

A comprehensive review of silk-fibroin hydrogels for cell and drug delivery applications in tissue engineering and regenerative medicine

Madappura,

Madduri

2023

Computational and Structural Biotechnology Journal

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Decoration of graphene oxide nanosheets with carboxymethylcellulose hydrogel, silk fibroin and magnetic nanoparticles for biomedical and hyperthermia applications

Abstract: In this study, efficient nanobiocomposite based on graphene oxide (GO), carboxymethylcellulose (CMC) hydrogel, silk fibroin (SF), and Fe3O4 nanoparticles were synthesized. For this purpose and in order to provide a...

Cited by 11 publications

References 43 publications

Green synthesis of biocompatible Fe 3 O 4 magnetic nanoparticles using Citrus Sinensis peels extract for their biological activities and magnetic- hyperthermia applications

Green synthesis of biocompatible Fe 3 O 4 magnetic nanoparticles using Citrus Sinensis peels extract for their biological activities and magnetic- hyperthermia applications

Green synthesis of biocompatible Fe3O4 magnetic nanoparticles using Citrus Sinensis peels extract for their biological activities and magnetic-hyperthermia applications

A comprehensive review of silk-fibroin hydrogels for cell and drug delivery applications in tissue engineering and regenerative medicine

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