A comprehensive review of silk-fibroin hydrogels for cell and drug delivery applications in tissue engineering and regenerative medicine

Madappura, Alakananda Parassini; Madduri, Srinivas

doi:10.1016/j.csbj.2023.10.012

Cited by 7 publications

(8 citation statements)

References 185 publications

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“…Biomaterials play a key role in tissue engineering by mimicking the tissue environment through engineered architectures for cell growth and by providing structural support for the delivery of cells and therapeutic factors [13].…”

Section: Biomaterials For Ddssmentioning

confidence: 99%

“…In particular, among these interesting biopolymers for DDSs, this review aims to focus attention on silk fibroin, which possesses ideal properties for drug delivery polymers and offers a bottom-up approach that helps to introduce novel features [13,24]. Indeed, silk has demonstrated multiple advantages, such as biocompatibility, biodegradability, non-toxic degradation products, sterilization, mechanical stability and self-assembly properties [17,18,25].…”

Section: Biomaterials For Ddssmentioning

confidence: 99%

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The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems

Pollini,

Paladini

2024

Biomimetics

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In order to reduce the toxicological impact on healthy cells and to improve the therapeutic response, many drug delivery systems have been fabricated and analysed, involving the use of different natural and synthetic materials at macro-, micro- and nanoscales. Among the natural materials which have demonstrated a huge potential for the development of effective drug delivery systems, silk fibroin has emerged for its excellent biological properties and for the possibility to be processed in a wide range of forms, which can be compliant with multiple active molecules and pharmaceutical ingredients for the treatment of various diseases. This review aims at presenting silk fibroin as an interesting biopolymer for applications in drug delivery systems, exploring the results obtained in recent works in terms of technological progress and effectiveness in vitro and in vivo.

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Section: Biomaterials For Ddssmentioning

confidence: 99%

Section: Biomaterials For Ddssmentioning

confidence: 99%

The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems

Pollini,

Paladini

2024

Biomimetics

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“…Tissue engineering is a highly multidisciplinary field that aims to substitute, repair, and replace damaged tissue in neurologic diseases, combining scaffolds, cells, and bioactive molecules, both in vitro and in vivo [ 1 , 2 , 3 , 4 ]. The combined effect of these three components offers advanced opportunities for tissue regeneration [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…The combined effect of these three components offers advanced opportunities for tissue regeneration [ 5 ]. Scaffolds can supply the basic physicochemical, structural, biomechanical, and biological environment for cellular function and neo-tissue formation [ 4 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Politrón-Zepeda,

Fletes-Vargas,

Rodríguez-Rodríguez

2024

Gels

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The repair of nervous tissue is a critical research field in tissue engineering because of the degenerative process in the injured nervous system. In this review, we summarize the progress of injectable hydrogels using in vitro and in vivo studies for the regeneration and repair of nervous tissue. Traditional treatments have not been favorable for patients, as they are invasive and inefficient; therefore, injectable hydrogels are promising for the treatment of damaged tissue. This review will contribute to a better understanding of injectable hydrogels as potential scaffolds and drug delivery system for neural tissue engineering applications.

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“…Silk fibroin has emerged as a biopolymer with superior potential application value in tissue engineering and regenerative medicine [ 1 ], owing to its biocompatibility, processability, and relatively mild processing conditions [ 2 , 3 ]. Various types of silk-based materials that undergo reprocessing, modification, and modulation are used in numerous areas, such as tissue engineering [ 4 ], drug delivery [ 5 ], 3D printing [ 6 ], cell coating [ 7 ], microfluidics [ 8 ], biosensors [ 9 ], and blood vessels [ 10 ]. Nevertheless, one of the major challenges for these silk-based biomaterials is safety and efficacy in vivo tissue healing [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Regulation of the Degradation Properties of Tyrosinase-Catalyzed Crosslinking Silk Membranes for Superficial Wound Repair

Liu,

Jiao

et al. 2024

Materials

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Appropriate biodegradability to meet the demands of wound repair is critical for superficial wound repair membrane applications. Tyrosinase-catalyzed crosslinking SF (c-SF) membranes were constructed and regulated the degradation behavior in this study. The crosslinking degree of the c-SF membranes could be adjusted by reaction ratios of tyrosinase against SF (TYR/SF). Upon reaching a TYR/SF ratio of 20/6000, the degree of crosslinking increased to 88.17 ± 0.20%, without obvious changes in the crystal structure. The degradation behavior was regulated by the TYR/SF ratio and the degradation environment. All c-SF membranes remained stable after immersion without collagenase but showed an adjustable degradation behavior in the presence of collagenase. As the TYR/SF ratio increased, the residual weights increased from 23.31 ± 1.35% to 60.12 ± 0.82% after 7 days of degradation, occurring with low increased amounts of β-sheet structure and free amino acids. This work provides a new c-SF membrane with controllable rapid degradability and favorable cytocompatibility, which can help to meet requirements for biodegradable superficial wound repair membranes.

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A comprehensive review of silk-fibroin hydrogels for cell and drug delivery applications in tissue engineering and regenerative medicine

Cited by 7 publications

References 185 publications

The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems

The Emerging Role of Silk Fibroin for the Development of Novel Drug Delivery Systems

Injectable Hydrogels for Nervous Tissue Repair—A Brief Review

Regulation of the Degradation Properties of Tyrosinase-Catalyzed Crosslinking Silk Membranes for Superficial Wound Repair

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