Decontamination and Sterilization of Sensitive Drugs using High Hydrostatic Pressure (HHP)

Rigaldie, Yohan; Largeteau, Alain; Lemagnen, Gilles; Grislain, L.; Demazeau, G.

doi:10.1007/978-3-662-05613-4_56

Cited by 3 publications

(6 citation statements)

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“…In a series of articles , and Demazeau (2003a, 2003b) studied the mpHHP inactivation of B. subtilis spores. The treatment of HHP (20 MPa, 37°C, 5 min) followed by another HHP treatment (500 MPa, 37°C, 5 min) which was applied 30 times could inactivate more than 6 log 10 of spores in solutions of insulin and heparin (Rigaldie et al, 2003a;2003b) whereas, the treatment of HHP (60 MPa, 25°C, 30 min) followed by another HHP treatment (500 MPa, 25°C, 30 min) which was applied 3 times could be used to inactivate 3 log 10 of B. subtilis spores (Rigaldie, Largeteau, et al, 2002a;2002b). According to these authors an induction phase using low pressure (20 MPa) was required for higher inactivation of spores.…”

Section: Bacterial and Fungal Sporesmentioning

confidence: 99%

Multi-pulsed high hydrostatic pressure inactivation of microorganisms: A review

Buzrul

2014

Innovative Food Science & Emerging Technologies

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Section: Bacterial and Fungal Sporesmentioning

confidence: 99%

Multi-pulsed high hydrostatic pressure inactivation of microorganisms: A review

Buzrul

2014

Innovative Food Science & Emerging Technologies

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“…In the first case, because of the energy developed by standard sterilization processes (chemicals, heat, ionizing radiation, etc.) and taking into account the cost of alternative methods such as sterile filtration followed by an aseptic filling, high‐pressure processes have been tested (Rigaldie et al. 2002b).…”

Section: The Development Of Hhp Processes For Pharmaceutical and Medimentioning

confidence: 99%

“…Some investigations have been carried out using different molecules of therapeutic relevance such as heparin, insulin (Rigaldie et al. 2002b), two peptides (Rigaldie et al.…”

Section: The Development Of Hhp Processes For Pharmaceutical and Medimentioning

confidence: 99%

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The development of high hydrostatic pressure processes as an alternative to other pathogen reduction methods

Demazeau

Rivalain

2011

Journal of Applied Microbiology

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Summary In biology, scientist’s interest for high hydrostatic pressure (HHP) has increased over the last 20 years, for both research and industrial developments, mainly because of the low energy associated with its application in liquid phase and its capacity to inactivate pathogens. It is now considered as an interesting alternative to heat treatments for the inactivation of contaminants in many products, from foods to pharmaceutical preparations. This last statement implies different objectives according to the type of product. The therapeutic properties of pharmaceutical preparations or other biological media of physiological importance are in general associated with specific and well‐defined molecules such as proteins. Their activity mainly depends on their spatial conformation, maintained by weak chemical bonds that are often pressure sensitive. In this case, the optimization of a HHP process can be more complex than for foods, for which the organoleptic molecules are less pressure sensitive, and the evaluation of their preservation is more subjective and highly dependant on the consumers acceptance. The objective of this review is therefore to underline how, even if the basic concept for the optimization of a pathogen reduction process using HHP is the same whatever the product, major differences arise from the product itself and its final use.

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“…In fact, it was shown that the expression of at least one gene (ERG25), which is involved in ergosterol biosynthesis in Saccharomyces cerevisiae, is upregulated under pressure stress conditions (Fernandes et al, 2004). Besides the natural occurrence, HHP is also applied technically to inactivate microorganisms in food, while retaining favorable product properties like texture or flavour (Matser et al, 2004), or for the sterilization of heat-sensitive pharmaceuticals (Rigaldie et al, 2002(Rigaldie et al, , 2003. The lethal effects of HHP are caused by the dissociation of macromolecular assemblies like ribosomes or the cytoskeleton and the pressure-induced denaturation of proteins Winter et al, 2007) or by alterations in membrane structure, dynamics and permeability, which lead to the failure of cell homeostasis Vogel et al, 2002).…”

Section: Introductionmentioning

confidence: 98%