Declining Populations of Freshwater Pearl Mussels (Margaritifera margaritifera) Are Burdened with Heavy Metals and DDT/DDE

Hartmut, Frank; Gerstmann, Silke

doi:10.1579/0044-7447(2007)36[571:dpofpm]2.0.co;2

Cited by 30 publications

(3 citation statements)

References 33 publications

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“…Molluscs are indeed widespread and versatile and can be used in almost all environments including marine [ 2 ], freshwater [ 3 ], terrestrial [ 4 ] and in different manners, depending on their tolerance to pollutants. Some species like the freshwater pearl mussel Margaritifera margaritifera , which grows exclusively in pristine water, are unerring indicators of water purity [ 5 ], since they rapidly disappear when the environment is polluted, even very temporarily [ 6 , 7 ]. Other species withstand pollution and exhibit the capacity to accumulate high content of heavy metals or organic pollutants in their living tissues and in their shell [ 8 ], without any apparent impairment of their physiological functions.…”

Section: Introductionmentioning

confidence: 99%

The Shell of the Invasive Bivalve Species Dreissena polymorpha: Biochemical, Elemental and Textural Investigations

et al. 2016

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The zebra mussel Dreissena polymorpha is a well-established invasive model organism. Although extensively used in environmental sciences, virtually nothing is known of the molecular process of its shell calcification. By describing the microstructure, geochemistry and biochemistry/proteomics of the shell, the present study aims at promoting this species as a model organism in biomineralization studies, in order to establish a bridge with ecotoxicology, while sketching evolutionary conclusions. The shell of D. polymorpha exhibits the classical crossed-lamellar/complex crossed lamellar combination found in several heterodont bivalves, in addition to an external thin layer, the characteristics of which differ from what was described in earlier publication. We show that the shell selectively concentrates some heavy metals, in particular uranium, which predisposes D. polymorpha to local bioremediation of this pollutant. We establish the biochemical signature of the shell matrix, demonstrating that it interacts with the in vitro precipitation of calcium carbonate and inhibits calcium carbonate crystal formation, but these two properties are not strongly expressed. This matrix, although overall weakly glycosylated, contains a set of putatively calcium-binding proteins and a set of acidic sulphated proteins. 2D-gels reveal more than fifty proteins, twenty of which we identify by MS-MS analysis. We tentatively link the shell protein profile of D. polymorpha and the peculiar recent evolution of this invasive species of Ponto-Caspian origin, which has spread all across Europe in the last three centuries.

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Section: Introductionmentioning

confidence: 99%

The Shell of the Invasive Bivalve Species Dreissena polymorpha: Biochemical, Elemental and Textural Investigations

et al. 2016

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“…For example, the Vramsån river has fine specimens of the very rare freshwater pearl mussel ( Margaritifera margaritifera ) [ 70 ] which can live for more than 250 years [ 71 ]. Being exposed to even minute amounts of contaminants for centuries may cause unknown effects, especially considering that these mussels are sensitive to environmental pollution [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

Total Release of 21 Indicator Pharmaceuticals Listed by the Swedish Medical Products Agency from Wastewater Treatment Plants to Surface Water Bodies in the 1.3 Million Populated County Skåne (Scania), Sweden

Björklund¹

2021

Molecules

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In 2017, the Swedish Environmental Protection Agency published a report on advanced wastewater treatment for the removal of pharmaceutical residues and stated that advanced treatment should be implemented where it will make the largest difference from an environmental perspective. However, the report also concluded that this need cannot be specified with existing data, but consideration must be made of local conditions. Two considerations are (1) the discharged amount of pharmaceutical into receiving water bodies and (2) the turnover of water in the recipient, where the highest risks are related to recipients with a low water turnover and low dilution. The current project comprised eight different WWTPs distributed throughout the entire County Skåne (Scania) in Sweden, with a population of ca. 1,300,000 persons. In total, 21 of 22 pharmaceuticals were analyzed according to the list proposed by the Swedish Medical Products Agency 2015. The results show that large amounts of pharmaceuticals are released from the WWTPs yearly to Scanian recipients. The total discharge of pharmaceuticals from the eight treatment plants adds up to 71 kg of these 21 substances alone, mainly comprising metoprolol, which is a drug that lowers blood pressure, and the analgesic drug diclofenac. Additionally, carbamazepine, losartan, naproxen and oxazepam were present in significant concentrations. These represented three illnesses that are very common: high blood pressure, inflammation/pain and depression/anxiety. The concentrations were generally in line with previous national Swedish screenings. It was estimated that, when one million cubic meters (1,000,000 m3) of wastewater is discharged, almost 4 kg of the 21 pharmaceuticals is released. The total volume wastewater release by the >90 WWTPs in Scania was estimated to 152,887,000 m3, which corresponded to 590 kg/year. The investigated 21 drugs cover only a small part of many hundred pharmaceuticals that are in use in Sweden. Thus, most likely, one or several tons of pharmaceuticals leak out to the Scanian recipients annually. The analysis of river samples shows that the dilution of wastewater is a key parameter in reducing concentrations. However, some locations have remarkably high concentrations, which occur when the volume wastewater is large in relation to the flow in the river. These kinds of regional results are of importance when selecting where advanced treatment should be prioritized in a first instance, as requested by the Swedish EPA.

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“…In addition, these contaminants can cause mitochondrial dysfunction. 44 In addition to genes involved in oxidative stress, some genes participated in the metabolism of xenobiotics through the cytochrome P450 pathway (ko: 00980), cytochrome P450 drug metabolism (ko: 00982), and arachidonic acid metabolism (ko: 00590). CYP450 is a large group of enzymes that are responsible for the oxidation of endogenous and exogenous substrates.…”

Section: Functional Genes Related To Oxidative Stress and Detoxificationmentioning

confidence: 99%

Differential gene responses in the embryo of the green mussel Perna viridis exposed to dichlorodiphenyltrichloroethane (DDT)

et al. 2017

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The green-lipped mussel, , is considered to be an ideal indicator for marine environmental pollution. Dichlorodiphenyltrichloroethane (DDT), a typical persistent organic pollutant, is extensively distributed in marine environments. However, little is known about the toxic effects of DDT on the embryo of marine animals, particularly in marine bivalves. Using next-generation sequencing technology, we studied embryo after DDT stress at the transcriptome level. A total of 99 202 unigenes were obtained based on the 2383 bp of unigene N50. These differentially expressed genes (DEGs) participated in the various molecular pathways of biological effects, including oxidative stress, detoxification, innate immunity and neurobehavioral disease. Quantitative real-time PCR was performed to verify the mRNA expression of several genes identified by differential gene expression (DGE) analysis. The results indicated that DDT was in induced a dose-dependent manner in the embryo of , and most genes involved in oxidative stress and detoxification were up-regulated by DDT exposure; however, the immunity-related genes were down-regulated, except the genes involved in phagocytosis. Gene expression changes in embryo from provide a preliminary basis to better understand the molecular toxic response mechanisms of embryo to DDT.

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Declining Populations of Freshwater Pearl Mussels (Margaritifera margaritifera) Are Burdened with Heavy Metals and DDT/DDE

Cited by 30 publications

References 33 publications

The Shell of the Invasive Bivalve Species Dreissena polymorpha: Biochemical, Elemental and Textural Investigations

The Shell of the Invasive Bivalve Species Dreissena polymorpha: Biochemical, Elemental and Textural Investigations

Total Release of 21 Indicator Pharmaceuticals Listed by the Swedish Medical Products Agency from Wastewater Treatment Plants to Surface Water Bodies in the 1.3 Million Populated County Skåne (Scania), Sweden

Differential gene responses in the embryo of the green mussel Perna viridis exposed to dichlorodiphenyltrichloroethane (DDT)

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