Declining levels of miR-382-3p at puberty trigger the onset of spermatogenesis

Gupta, Alka; Mandal, Kunal Kumar; Singh, Parminder; Sarkar, Rajesh; Majumdar, Subeer S.

doi:10.1016/j.omtn.2021.07.001

Cited by 9 publications

(8 citation statements)

References 87 publications

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“…This impairment is characterized by non-obstructive oligospermia and complete infertility. These changes may be attributed to the decreased expression of important genes such as AR, WT1, GJA1, INHBB1, ESR1, CREB1, and PTEN ( 132 ). SCs are the exclusive targets of FSH in the testes.…”

Section: Mechanism Of Mirna Involved In Spermatogenesismentioning

confidence: 99%

MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers

Shi,

Yu,

Guo

et al. 2024

Front. Endocrinol.

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Infertility affects approximately 10–15% of couples worldwide who are attempting to conceive, with male infertility accounting for 50% of infertility cases. Male infertility is related to various factors such as hormone imbalance, urogenital diseases, environmental factors, and genetic factors. Owing to its relationship with genetic factors, male infertility cannot be diagnosed through routine examination in most cases, and is clinically called ‘idiopathic male infertility.’ Recent studies have provided evidence that microRNAs (miRNAs) are expressed in a cell-or stage-specific manner during spermatogenesis. This review focuses on the role of miRNAs in male infertility and spermatogenesis. Data were collected from published studies that investigated the effects of miRNAs on spermatogenesis, sperm quality and quantity, fertilization, embryo development, and assisted reproductive technology (ART) outcomes. Based on the findings of these studies, we summarize the targets of miRNAs and the resulting functional effects that occur due to changes in miRNA expression at various stages of spermatogenesis, including undifferentiated and differentiating spermatogonia, spermatocytes, spermatids, and Sertoli cells (SCs). In addition, we discuss potential markers for diagnosing male infertility and predicting the varicocele grade, surgical outcomes, ART outcomes, and sperm retrieval rates in patients with non-obstructive azoospermia (NOA).

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Section: Mechanism Of Mirna Involved In Spermatogenesismentioning

confidence: 99%

MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers

Shi,

Yu,

Guo

et al. 2024

Front. Endocrinol.

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“…Researchers have developed a transgenic mouse model in which the downregulation of miR-382-3p was prevented by overexpression in mature Scs (45).…”

Section: Micrornas In Male Infertilitymentioning

confidence: 99%

The role of MicroRNAs in female and male human reproduction: A Narrative Review

khoshandam,

Khoshandam,

Naserpour

et al. 2023

Preprint

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The role of MicroRNAs in human reproduction is exciting, and probably these regulatory molecules have an essential role in reproductive function. Currently, the regulatory role of miRNAs in male and female reproduction needs to be clearly understood, with a considerable amount of controversial and contradictory data. A targeted review of high-quality studies published to date on miRNA patterns related to female and male reproduction to describe their role and relationship with infertility and update knowledge in this field.A comprehensive review of the literature published in the PubMed -MEDLINE and Google Scholar databases from the first year of available online cataloging to 2022. Early outcome of miRNA expression in miRNAs, infertility, PCOS, endometriosis, and biomarkers identified 18,100 articles. Based on aims, 72 articles were selected. Regarding the presence and content of MicroRNAs, this review showed that each tissue and cell contains a well-defined and stable population of MicroRNAs that can be potentially related to spermatogenesis and oogenesis. Our extensive review of studies indicates a consistent relationship between aberrant miRNA expression and infertility. Therefore, measuring the expression of specific miRNAs identified is beneficial as biomarkers for male and female infertility and for developing new and specialized treatments.

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“…In addition to their expression in germ cells, several miRNAs have been identified in Sertoli and Leydig cells, where they regulate the activity of these somatic cells [ 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 ].…”

Section: The Role Of Mirnas In Spermatogenesismentioning

confidence: 99%

The Role of microRNA in Spermatogenesis: Is There a Place for Fertility Preservation Innovation?

Klees,

Alexandri,

Demeestere

et al. 2023

IJMS

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Oncological treatments have dramatically improved over the last decade, and as a result, survival rates for cancer patients have also improved. Quality of life, including concerns about fertility, has become a major focus for both oncologists and patients. While oncologic treatments are often highly effective at suppressing neoplastic growth, they are frequently associated with severe gonadotoxicity, leading to infertility. For male patients, the therapeutic option to preserve fertility is semen cryopreservation. In prepubertal patients, immature testicular tissue can be sampled and stored to allow post-cure transplantation of the tissue, immature germ cells, or in vitro spermatogenesis. However, experimental techniques have not yet been proven effective for restoring sperm production for these patients. MicroRNAs (miRNAs) have emerged as promising molecular markers and therapeutic tools in various diseases. These small regulatory RNAs possess the unique characteristic of having multiple gene targets. MiRNA-based therapeutics can, therefore, be used to modulate the expression of different genes involved in signaling pathways dysregulated by changes in the physiological environment (disease, temperature, ex vivo culture, pharmacological agents). This review discusses the possible role of miRNA as an innovative treatment option in male fertility preservation–restoration strategies and describes the diverse applications where these new therapeutic tools could serve as fertility protection agents.

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Declining levels of miR-382-3p at puberty trigger the onset of spermatogenesis

Cited by 9 publications

References 87 publications

MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers

MicroRNAs in spermatogenesis dysfunction and male infertility: clinical phenotypes, mechanisms and potential diagnostic biomarkers

The role of MicroRNAs in female and male human reproduction: A Narrative Review

The Role of microRNA in Spermatogenesis: Is There a Place for Fertility Preservation Innovation?

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