Declines in serum free and bound choline concentrations in humans after three different types of major surgery

İlçöl, Yeşim Özarda; Uncu, Gürkan; Gören, Suna; Sayan, Halil Erkan; Ulus, İsmail H.

doi:10.1515/cclm.2004.259

Cited by 11 publications

(13 citation statements)

References 26 publications

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“…Sixty (60) of the 242 mothers (25%) had a history of anxiety disorder. Mothers with a history of anxiety disorder were more likely than mothers without to meet diagnostic criteria for current or residual anxiety (63% versus 0%; chi 2 = 136.7; p <.001) and depressive disorders (23% versus 4%; chi 2 = 16.7; p <.001) and to utilize antidepressants (24% versus 7%; chi 2 = 11.9; p =.001) during pregnancy.…”

Section: Resultsmentioning

confidence: 99%

Antidepressants May Mitigate the Effects of Prenatal Maternal Anxiety on Infant Auditory Sensory Gating

Hunter

Mendoza²,

D'Anna³

et al. 2012

AJP

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Objective Prenatal maternal anxiety has detrimental effects on the resulting offspring’s neurocognitive development, including impaired attentional function. Antidepressants are commonly utilized during pregnancy, yet their impact on offspring attention and their interaction with maternal anxiety has not been assessed. Using P50 auditory sensory gating, a putative marker of early attentional processes measurable in young infants, the impact of maternal anxiety and antidepressant use are explored. Method Two hundred forty-two mother-infant dyads were classified relative to maternal history of anxiety and maternal prenatal antidepressant use. Infant P50 auditory sensory gating was recorded during active sleep at a mean± standard deviation of 76 ± 38 days of age. Results In the absence of prenatal antidepressant exposure, infants with mothers with a history of anxiety diagnoses had diminished P50 sensory gating (p<.001). Prenatal antidepressants mitigated the effect of anxiety (uncorrected p=.041). The effect of maternal anxiety was limited to amplitude of response to the second stimulus while antidepressants impacted the amplitude or response to both the first and second stimulus. Conclusion Maternal anxiety disorders are associated less inhibition during infant sensory gating, a performance deficit mitigated by prenatal antidepressant use. This effect may be important in considering the risks and benefits of prenatal antidepressant treatment. Cholinergic mechanisms are hypothesized for both anxiety and antidepressant effects; however the cholinergic receptors involved are likely different for anxiety and antidepressant effects. Additional work focused on understanding how treatment impacts the relationship between maternal prenatal illness and offspring neurocognitive development is indicated.

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Section: Resultsmentioning

confidence: 99%

Antidepressants May Mitigate the Effects of Prenatal Maternal Anxiety on Infant Auditory Sensory Gating

Hunter

Mendoza²,

D'Anna³

et al. 2012

AJP

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“…1). To our knowledge, there are few data available on the relation between free and bound choline concentrations in the circulation, and the published data in dogs and humans show a decline in serum-free choline accompanied by a decrease in serum phospholipid-bound choline concentration in response surgery (13,14), childbirth (12), running a marathon (31), and methylprednisolone administration (14). Serum-free and phospholipid-bound choline increase together during pregnancy (12).…”

Section: Discussionmentioning

confidence: 99%

“…Although these data clearly demonstrate that availability of choline is very important in response to endotoxin, to our knowledge, no data is available about circulating choline status during endotoxemia. Recent studies from our laboratory have shown that serum-free and phospholipid-bound choline concentrations decline in response to surgical and traumatic injuries in humans (10)(11)(12)(13) and in dogs (14). In light of these observations, and considering that endotoxemia is associated with tissue injury and multiorgan damage/failure, we hypothesized that circulating choline status is likely to be altered during endotoxemia.…”

Section: Introductionmentioning

confidence: 99%

Endotoxin Alters Serum-Free Choline and Phospholipid-Bound Choline Concentrations, and Choline Administration Attenuates Endotoxin-Induced Organ Injury in Dogs

İlçöl¹,

Yılmaz

Ulus³

2005

Shock

Self Cite

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This study in dogs was performed to assess circulating choline status during endotoxemia and to determine whether choline administration can protect dogs from endotoxin-induced tissue injuries. Baseline serum-free and phospholipid-bound choline concentrations were 19.2 +/- 0.6 micromol/L and 3700 +/- 70 micromol/L, respectively. After intravenous endotoxin infusion, serum-free choline concentrations decreased by 14% to 49% (P < 0.05-0.001) at 2 to 6 h after 0.02 mg/kg endotoxin, and increased by 23% to 98% (P < 0.05-0.001) at 1 to 48 h after 1 mg/kg endotoxin. Serum phospholipid-bound choline concentrations increased by 19% to 27% (P < 0.05) at 12 to 24 h or by 18% to 53% (P < 0.05-0.001) at 1 to 48 h after 0.02 or 1 mg/kg endotoxin, respectively. The changes in serum-free and -bound choline levels in response to endotoxin were accompanied by dose- and time-related elevations in serum cortisol and biochemical markers for tissue injury and/or organ dysfunction. Intravenous administration of choline (20 mg/kg) 5 min before, and 4 and 8 h after endotoxin (1 mg/kg) attenuated endotoxin-induced elevations in serum alanine aminotransferase (P < 0.05-0.001), aspartate aminotransferase (P < 0.05-0.001), gamma-glutamyl transferase (P < 0.05-0.001), alkaline phosphatase (P < 0.05-0.001), lactate dehydrogenase (P < 0.05-0.001), myocardial creatine kinase (P < 0.001), urea (P < 0.05-0.01), creatinine (P < 0.05), uric acid (P < 0.01-0.001), and tissue necrosis factor-alpha (P < 0.001). Choline also attenuated alanine aminotransferase (P < 0.05-0.01), alkaline phosphatase (P < 0.05-0.01), lactate dehydrogenase (P < 0.05-0.01), creatine kinase (P < 0.05-0.001), myocardial creatine kinase (P < 0.05-0.001), and uric acid (P < 0.05-0.01), but failed to alter the serum urea, creatinine, aspartate aminotransferase, and gamma-glutamyl transferase responses to 0.02 mg/kg endotoxin. These data show that choline status is altered during endotoxemia and that choline administration diminishes endotoxin-induced tissue injury.

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“…Interestingly, smoking is associated with significantly lower PCho concentrations and the reasons for this are unknown [8]. Declines and/ or lower levels of plasma or SCho have been found after major surgery [41], traumatic head injury [40] and more gradually during long-term parenteral nutrition [42]. These and other factors leading to abnormal choline levels are summarized in Box 3.…”

Section: Choline Values In Health Acs and Other Diseasesmentioning

confidence: 99%

Choline in acute coronary syndrome: an emerging biomarker with implications for the integrated assessment of plaque vulnerability

Danne

Möckel

2010

Expert Review of Molecular Diagnostics

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Declines in serum free and bound choline concentrations in humans after three different types of major surgery

Cited by 11 publications

References 26 publications

Antidepressants May Mitigate the Effects of Prenatal Maternal Anxiety on Infant Auditory Sensory Gating

Antidepressants May Mitigate the Effects of Prenatal Maternal Anxiety on Infant Auditory Sensory Gating

Endotoxin Alters Serum-Free Choline and Phospholipid-Bound Choline Concentrations, and Choline Administration Attenuates Endotoxin-Induced Organ Injury in Dogs

Choline in acute coronary syndrome: an emerging biomarker with implications for the integrated assessment of plaque vulnerability

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