Decline in Reproductive Success, Sex Reversal, and Developmental Alterations in Japanese Medaka (Oryzias latipes) after Continuous Exposure to Octylphenol

Knörr, Susanne; Braunbeck, Thomas

doi:10.1006/eesa.2001.2123

Cited by 53 publications

(27 citation statements)

References 46 publications

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“…Thus, the effects of estrogen-mimicking EDCs on sexual differentiation in teleosts have become a matter of concern. Most studies have focused on xenoestrogens that are structurally similar to 17β-estradiol (E 2 ), such as 17α-ethinylestradiol (EE 2 ), 4-octylphenol, and o,p′-DDT, which are thought to exert their estrogenic effects on gonadal differentiation by mimicking the actions of endogenous estrogens and thereby inducing phenotypic feminization (Knörr and Braunbeck, 2002;Andersen et al, 2003;Kuhl et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Monocrotophos pesticide modulates the expression of sexual differentiation genes and causes phenotypic feminization in zebrafish (Danio rerio)

Zhang

Gao

Yang

et al. 2013

Comparative Biochemistry and Physiology Part C: Toxicology &

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Section: Introductionmentioning

confidence: 99%

Monocrotophos pesticide modulates the expression of sexual differentiation genes and causes phenotypic feminization in zebrafish (Danio rerio)

Zhang

Gao

Yang

et al. 2013

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…In many fish species sexual differentiation appears to be a relatively plastic process that has proved to be especially vulnerable to the endocrine-disrupting effects of APs (Gimeno et al, 1996;Seki et al, 2003;Gronen et al, 1999;Kang et al, 2003;Knorr and Braunbeck, 2002). Very little is known about the developmental processes that govern sexual differentiation in fish and especially in marine fish like Atlantic cod (Gadus morhua).…”

Section: Introductionmentioning

confidence: 99%

Development of Atlantic cod (Gadus morhua) exposed to produced water during early life stages: Effects on embryos, larvae, and juvenile fish

Meier

Morton

Nyhammer

et al. 2010

Marine Environmental Research

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Produced water (PW) contains numerous toxic compounds of natural origin, such as dispersed oil, metals, alkylphenols (APs), and polycyclic aromatic hydrocarbons (PAHs). In addition, PW also contains many different chemicals which have been added during the oil production process. In the study described here, cod were exposed to real PW collected from an oil production platform in the North Sea. This was done in order to best recreate the most realistic field-exposure regime in which fish will be affected by a wide range of chemicals. The biological effects found in this study therefore cannot be assigned to one group of chemicals alone, but are the result of exposure to the complex chemical mixture found in real PW. Since APs are well known to cause endocrine disruption in marine organisms, we focused our chemical analysis on APs in an attempt to better understand the long-term effects of APs from PW on the biology of fish. In this study, cod were exposed to several concentrations of real PW and 17β-oestradiol (E(2)), a natural oestrogen, at different developmental stages. Cod were exposed to PW either during the embryo and early larvae stage (up to 3 months of age) or during the early juvenile stage (from 3 to 6 months of age). Results showed that, in general, APs bioconcentrate in fish tissue in a dose and developmental stage dependent manner during PW exposure. However, juveniles appeared able to effectively metabolise the short chain APs. Importantly, PW exposure had no effect on embryo survival or hatching success. However, 1% PW clearly interfered with the development of normal larval pigmentation. After hatching most of the larvae exposed to 1% PW failed to begin feeding and died of starvation. This inability to feed may be linked to the increased incidence of jaw deformities seen in these larvae. In addition, cod exposed to 1% PW, had significantly higher levels of the biomarkers vitellogenin and CYP1A in plasma and liver, respectively. No similar effects were seen in cod exposed to either 0.1% or 0.01% PW.

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“…A number of researches on the reproduction failure, development inhibition and other toxic effects of endocrine disruptors have been well documented using medaka (Kimm-Brinson and Ramsdell, 2001;Islinger et al, 2002;Kang et al, 2002;Knorr and Braunbeck, 2002). To our knowledge, little is known about the toxicological effects that would occur on medaka after sublethal levels' exposure of MeHg, such as the distribution of the pollutant in the fish bodies, histopathological changes and AChE activity alteration in different tissues of medaka, resulting in emptiness of the diagnosis for MeHg exposure and intoxication at low levels (Wester and Canton, 1991).…”

Section: Introductionmentioning

confidence: 99%

Methylmercury accumulation, histopathology effects, and cholinesterase activity alterations in medaka (Oryzias latipes) following sublethal exposure to methylmercury chloride

Liao

Shi

et al. 2006

Environmental Toxicology and Pharmacology

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Decline in Reproductive Success, Sex Reversal, and Developmental Alterations in Japanese Medaka (Oryzias latipes) after Continuous Exposure to Octylphenol

Cited by 53 publications

References 46 publications

Monocrotophos pesticide modulates the expression of sexual differentiation genes and causes phenotypic feminization in zebrafish (Danio rerio)

Monocrotophos pesticide modulates the expression of sexual differentiation genes and causes phenotypic feminization in zebrafish (Danio rerio)

Development of Atlantic cod (Gadus morhua) exposed to produced water during early life stages: Effects on embryos, larvae, and juvenile fish

Methylmercury accumulation, histopathology effects, and cholinesterase activity alterations in medaka (Oryzias latipes) following sublethal exposure to methylmercury chloride

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