Deciphering magnetic hyperthermia properties of compositionally and morphologically modulated FeNi nanoparticles using first-order reversal curve analysis

Abstract

Magnetic hyperthermia based on nanoparticles (NPs) is considered a significant approach in cancer therapy. However, less attention has been paid to the correlation between hyperthermia properties and detailed magnetic characteristics. Herein, the hyperthermia capability of FexNi100-x (8 ≤ × ≤ 40) NPs synthesized using a polyol method was studied by investigating the temperature rise and specific loss power (SLP) of their ferrofluid (FF) solutions while also performing first-order reversal curve (FORC) analysis. The colloidal stability of magnetic NPs in the FFs was enhanced by coating their surface with polyethylene glycol, and the hyperthermia experiments were carried out in ethylene glycol and DI water (DIW) dispersion media using different concentrations (1.25, 2.5 and 5 mg ml−1). A field-emission scanning electron microscope was employed to characterize the morphology of the FeNi NPs, evidencing mean diameters ranging between 64–112 nm. Hysteresis loop measurements showed a decreasing trend of average coercive field from 94 to 52 Oe when decreasing the diameter, coinciding with a 13% increase in the reversible fraction of single-domain and superparamagnetic (SP) NPs, according to FORC results. In this way, the corresponding SLP value increased from 55 to 264 W g−1 for FFs in 1.25 mg ml−1 concentrated DIW medium with an SP fraction of 40%.

Magnetic Nanocomposite Hydrogels for Tissue Engineering: Design Concepts and Remote Actuation Strategies to Control Cell Fate

“…A different strategy to modulate the magnetic properties of MNPs consists of the modification of their internal composition. Several magnetic materials such as iron carbides, 78 iron−platinum, 79 or iron−nickel 80 have been prepared in the form of nanoparticles. However, as mentioned above, iron oxide-based MNPs are the most commonly used due to their easy/cheap synthesis and low toxicity degree, so here we will focus in the modification of the composition of these kinds of MNPs.…”

Monometallic and alloy nanoparticles: a review of biomedical applications

“…FeNi NPs were proposed as magnetic hyperthermia agents with an enhanced heat dissipation capability. 66 Since the composition, especially the ratio of elements in the nanocrystal, affects its characteristics, the magnetic properties of NPs with different Fe x Ni 100− x compositions (80 ≤ x ≤ 40) were analysed. 66 Alloy NPs with the required elemental ratio were prepared via a typical polyol process.…”

“…66 Since the composition, especially the ratio of elements in the nanocrystal, affects its characteristics, the magnetic properties of NPs with different Fe x Ni 100− x compositions (80 ≤ x ≤ 40) were analysed. 66 Alloy NPs with the required elemental ratio were prepared via a typical polyol process. Iron( ii ) chloride and nickel( ii ) chloride were added to propylene glycol for further dissolution (170 °C).…”

The mechanism underlying the functionalisation of cobalt nanoparticles by carboxylic acids: a first-principles computational study

“…11,12 Originating from the popularity of innocuous iron oxides, Fe NPs were a natural first choice and their smaller size and improved magnetic properties have suggested that iron-based magnetic carriers would be superior to the existing maghemite and magnetite NPs. 13 Combinations of Fe with other metals, such as FePt, [14][15][16] FeNi, 17,18 and FeCo [19][20][21] nanoalloys, also appeared attractive. However, the high magnetic moment of cobalt NPs gives them an intrinsic advantage over the aforementioned materials, which can be exploited specifically in mNPH, where a combination of magnetisation and small diameters is crucial for the desired performance.…”