Deciphering and predicting anammox-based nitrogen removal process under oxytetracycline stress via kinetic modeling and machine learning based on big data analysis

Xu, Xinxin; Du, Tingting; Guo, Du; Jiang, Xinye; Zeng, Ming; Wu, Nan; Wang, Chang; Zhang, Zongpeng

doi:10.1016/j.scitotenv.2021.148980

Cited by 13 publications

(2 citation statements)

References 32 publications

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“…Anammox was reportedly inhibited when the OTC concentration reached 2 mg/L. 30 We previously reported that 50 mg/L OTC inhibited TN removal in the anammox process and TN removal efficiency decreased from 87.3 to 68.4% during a 48 day experiment. 4 In terms of SDZ, the anammox consortia previously exhibited great tolerance to stress induced by 10 mg/L SDZ.…”

Section: Resultsmentioning

confidence: 91%

“…Anammox inhibition by OTC is reportedly caused by cell membrane damage and protein synthesis inhibition, while SDZ inhibits bacterial growth and reproduction by competing with p -aminobenzoic acid in the enzymatic synthesis of dihydrofolic acid. , Nevertheless, the impacts of OTC or SDZ on anammox depend on the antibiotic concentration. Anammox was reportedly inhibited when the OTC concentration reached 2 mg/L . We previously reported that 50 mg/L OTC inhibited TN removal in the anammox process and TN removal efficiency decreased from 87.3 to 68.4% during a 48 day experiment .…”

Section: Resultsmentioning

confidence: 93%

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Nitrogen Removal Performance and Microbial Response of Anammox Under Multiantibiotic Stress: Effect of Static Magnetic Field

Lu,

Zhu,

Shen

et al. 2024

Ind. Eng. Chem. Res.

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The long-term impacts of multiantibiotics (oxytetracycline and sulfadiazine) on the anaerobic ammonium oxidation (anammox) process were investigated, and the effectiveness of static magnetic field (SMF) in relieving the multiantibiotic stress was analyzed. Nitrogen removal efficiency and anammox activity were severely inhibited by multiantibiotic exposure, which was persistent and irreversible even after their removal from the influent. The relative abundances of antibiotic resistance genes (ARGs) related to antibiotic inactivation and efflux pumps exhibited substantial increases under multiantibiotic stress. The relative abundances of ARGs targeting sulfonamide and tetracycline represented only 6.7− 18.9% of the total abundance, with sul2 being the most prevalent ARG. Coexisting heterotrophic bacteria were identified as potential ARG hosts, while anammox bacteria, particularly Candidatus Kuenenia, exhibited negative correlations with most ARGs. Antibiotics and SMF appeared to play important roles in ARG evolution. SMF could relieve anammox inhibition by multiple antibiotics through improved aggregation of anammox granules and enhanced metabolism and environmental information processing.

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Section: Resultsmentioning

confidence: 91%