Decidual-trophoblast interactions: decidual lymphoid cell function in normal, anembryonic, missed abortion and ectopic human pregnancy

Petrović, Oleg; Gudelj, Lea; Rubeša, Gordana; Haller, Herman; Beer, Alan E.; Rukavina, Daniel

doi:10.1016/0165-0378(94)90020-5

Cited by 27 publications

(10 citation statements)

References 28 publications

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“…CD8+ T cells have been proposed to have an immunoregulatory role in normal pregnancy. Defciency in suppressor cells and factors has been suggested to contribute to the pathogenesis of spontaneous abortion [27, 28]. However, Vassiliadou had demonstrated that in common with normal pregnancy, most endometrial T cells expressed CD8+, thus implying that reduced CD8-positive cell-mediated immunosuppression is unlikely to play a role in adverse pregnancy outcome [29].…”

Section: Discussionmentioning

confidence: 99%

Quercetin and Bornyl Acetate Regulate T‐Lymphocyte Subsets and INF‐γ/IL‐4 Ratio In Utero in Pregnant Mice

Wang

Shi

et al. 2010

Evidence-Based Complementary and Alternative Medicine

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The objective of this study is to investigate the antiabortive effects of Quercetin and Bornvl Acetate and their immunological modulation at maternal-fetal interface. Lipopolysaccharide (LPS) was injected via tail vein to induce abortion in mice which received Quercetin and Bornvl Acetate at days 4–7 of gestation. Uterine CD4+/CD8+ T lymphocytes and IFN-γ/IL-4 of each group (n = 10) were detected by immunohistochemistry and enzyme-linked immunosorbent assay, respectively. The ratio of CD4+/CD8+ increased significantly (P < .01) in the uterus of LPS-induced abortion mice. In the Quercetin and Bornvl Acetate pretreated mice followed by LPS administration, the ratio of CD4+/CD8+ dropped to 0.562 ± 0.021, lower than that of LPS-abortion group (P < .01). The mean value of IFN-γ/IL-4 in LPS-treated mice was 0.310 ± 0.066, higher than that of Quercetin and Bornyl Acetate group. The results indicate that Quercetin and Bornyl Acetate have an antiabortive effect through modulation of immunological balance at maternal-fetal interface.

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Section: Discussionmentioning

confidence: 99%

Quercetin and Bornyl Acetate Regulate T‐Lymphocyte Subsets and INF‐γ/IL‐4 Ratio In Utero in Pregnant Mice

Wang

Shi

et al. 2010

Evidence-Based Complementary and Alternative Medicine

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“…The stress-triggered abortions were associated with high levels of tumor necrosis Accepted May 22, 1995 factor a (TNFa) and subnormal levels of transforming growth factor [32 (TGFP32)-mediated suppression in the decidua on Day 13.5 of gestation when the aborted embryos were counted [2]. As in mice, human recurrent pregnancy losses have been linked to the influence of stress, to increased NK cell activity, and to decreased TGFJ32-related suppressive activity in the decidua, and these losses may be preventable by immunization [7][8][9]. Experiments using mice are therefore potentially relevant to understanding effects of stress in the human species.…”

Section: Introductionmentioning

confidence: 99%

Stress-Induced Murine Abortion Associated with Substance P-Dependent Alteration in Cytokines in Maternal Uterine Decidua1

Arck

Merali

Stanisz

et al. 1995

Biology of Reproduction

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Stress is known to induce abortions, but underlying mechanisms are unknown. Both alloimmunization and injection of antibody to the asialoGM1 determinant of natural killer cells have been shown to prevent stress-triggered abortion in mice. DBA/2J-mated CBA/J female mice were used to investigate the influence of stress during early gestation on systemic hormone levels and on cytokines in the decidua that are thought to be relevant to abortion in nonstress-related murine abortion. Lowered levels of progesterone did not occur as a result of stress. In stressed mice, increased levels of the abortogenic cytokine tumor necrosis factor alpha (TNF alpha) were associated with decreased levels of pregnancy-protective transforming growth factor beta 2-related suppressive activity in uterine decidua. In the alloimmunized animals where stress failed to boost the abortion rate, these effects were abrogated. Production of TNF alpha may be stimulated by the neurotransmitter substance P (SP); after injection of an SP receptor antagonist or SP-antibody, stress failed to increase the abortion rate above the background level. The increased levels of TNF alpha we observed in the stressed animals were completely abrogated in the animals that had received the SP receptor antagonist; stress also failed to decrease the pregnancy-protective suppressive activity in the decidua of these animals. The data indicate that stress may inhibit protective suppressor mechanisms and promote secretion of abortogenic cytokines such as TNF alpha via neurotransmitter SP.

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“…This recognition may result in antigen-specific T-cell responses [79]. The active nature of the reaction is proven by increased proliferation of leukocytes after contact to the fetal trophoblast cells [80].…”

Section: Recognition Of Fetal Antigens By the Maternal Immune Systemmentioning

confidence: 99%

Fetal tolerance in human pregnancy—A crucial balance between acceptance and limitation of trophoblast invasion

Rango

2008

Immunology Letters

119

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Decidual-trophoblast interactions: decidual lymphoid cell function in normal, anembryonic, missed abortion and ectopic human pregnancy

Cited by 27 publications

References 28 publications

Quercetin and Bornyl Acetate Regulate T‐Lymphocyte Subsets and INF‐γ/IL‐4 Ratio In Utero in Pregnant Mice

Quercetin and Bornyl Acetate Regulate T‐Lymphocyte Subsets and INF‐γ/IL‐4 Ratio In Utero in Pregnant Mice

Stress-Induced Murine Abortion Associated with Substance P-Dependent Alteration in Cytokines in Maternal Uterine Decidua1

Fetal tolerance in human pregnancy—A crucial balance between acceptance and limitation of trophoblast invasion

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