Dechlorination of chlorotoluene rectification residual liquid (CRRL) by using Williamson ether synthesis (WES) method

Ye, Long; Jin, Zhiyuan; Li, Lijun; Zhang, Mingxin; Hu, Lifang; Shen, Dongsheng; Ruan, Jinmu

doi:10.1007/s11356-020-07957-4

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…(Sodium tertiary alcohol is difficult to form and is not easy to react with halogenated hydrocarbons after formation, so tertiary halogenated hydrocarbons are often used to prepare ethers under weakly alkaline conditions.) [3]…”

Section: Effects Of Side Effects 1151 Elimination Reactionmentioning

confidence: 99%

Williamson Ether Synthesis: O-Alkylation Reaction Using Halogenated Hydrocarbons as Alkylating Agents

2023

AJMC

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The Williamson synthesis method is a method for preparing asymmetric ethers, which is obtained by the reaction of halogenated hydrocarbons with sodium alcohol or sodium phenol. According to literature research, the influencing factors of this reaction include halogenated hydrocarbons, alkylated alcohols, catalysts, solvents, and side reactions; In addition, this method can be used to introduce various substituents such as saturated, unsaturated, aliphatic, and aromatic hydrocarbon groups in drug synthesis, thereby obtaining a variety of pharmaceutical intermediates or drugs. This article selects the antitumor drug gefitinib involved in this reaction as a case study to illustrate the complete synthesis route of this drug. Other reaction types and names involved in the drug synthesis route are also described.

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Section: Effects Of Side Effects 1151 Elimination Reactionmentioning

confidence: 99%

Williamson Ether Synthesis: O-Alkylation Reaction Using Halogenated Hydrocarbons as Alkylating Agents

2023

AJMC

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“…An important route to unsymmetrical ethers is a nucleophilic substitution reaction S N 2 known as The Williamson reaction process is still considered one of the best ways to synthesize an ether, from an alkyl halide with alkoxide or phenoxide ions. 5 This reaction was developed by Alexander Williamson in 1980 by the reaction between the alkoxide ion or phenoxide with primary alkyl halides and one of the most important properties of this reaction is that there's not water as a by-product of the reaction. 6.7 The purpose of this research is to combine the vinyl group with azo-phenol dyes, which leads to convert the dyes into colored polymers.…”

Section: Introductionmentioning

confidence: 99%

اصطناع بوليميرات آزو ببلمرة مشتاقات إيتيرية لبروميد الآليل ودراسة فجوتها الطاقية وتعيين بعض خصائصها الفيزيائية

Jawish¹

2021

Journal of Natural Sciences, Life and Applied Sciences

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In this research, two ether derivatives of phenolic azo dyes were synthesized via Williamson's reaction according to the SN2 mechanism. The prepared compounds were radically polymerized using (AIBN) as an initiator and their structures were identified by FT-IR and 1H-NMR. Furthermore, thermal properties of these polymers was made by (DSC). Bandgap energy have been calculated to indicate the ability of these polymers as optical semiconductors, it was 2.8ev, 2.4ev for P(AO2) and P(AON1) respectively. Beside the determination of refractive index, kinematic viscosity, density, and degree of Turbidity.

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Dechlorination of chlorotoluene rectification residual liquid (CRRL) by using Williamson ether synthesis (WES) method

Cited by 2 publications

References 19 publications

Williamson Ether Synthesis: O-Alkylation Reaction Using Halogenated Hydrocarbons as Alkylating Agents

Williamson Ether Synthesis: O-Alkylation Reaction Using Halogenated Hydrocarbons as Alkylating Agents

اصطناع بوليميرات آزو ببلمرة مشتاقات إيتيرية لبروميد الآليل ودراسة فجوتها الطاقية وتعيين بعض خصائصها الفيزيائية

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