Williamson Ether Synthesis: O-Alkylation Reaction Using Halogenated Hydrocarbons as Alkylating Agents
Abstract:The Williamson synthesis method is a method for preparing asymmetric ethers, which is obtained by the reaction of halogenated hydrocarbons with sodium alcohol or sodium phenol. According to literature research, the influencing factors of this reaction include halogenated hydrocarbons, alkylated alcohols, catalysts, solvents, and side reactions; In addition, this method can be used to introduce various substituents such as saturated, unsaturated, aliphatic, and aromatic hydrocarbon groups in drug synthesis, the… Show more
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